Molecular Characterization of a Novel Gamma-Glutamyl Transpeptidase Homologue Found in Rat Brain.
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概要
- 論文の詳細を見る
A eDNA clone for a novel homologue to γ-glutamyl transpeptidase (γ-GTP), termed GTPH, was isolated from a rat brain expression cDNA library using antisera against total brain synaptosomal fractions. The cloned GTPH consists of 641 amino acid residues (78 kDa) and exhibits structural similarity with a conventional type of γ-GTP that is predominantly expressed in the liver: They share significant amino acid homology (33% identity, 73% similarity) spanning over the entire sequence. RNA analyses revealed that GTPH mRNA expression is found only in the nervous system, including all brain regions, eyes and peripheral ganglia, and increases during development. Endogenous GTPH protein is a membrane-bound glycoenzyme and migrates as 90-100 kDa in polyacrylamide gels. Taken together, GTPH is a novel form of a γ-GTP-like molecule expressed exclusively in the nervous system.
- 社団法人 日本生化学会の論文
著者
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Ishii Kyoko
Department Of Molecular Neurobiology Brain Research Institute Niigata University
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Takei Nobuyuki
Department Of Molecular Neurobiology Brain Research Institute Niigata University
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Nawa Hiroyuki
Department Of Mol. Neurobiol. Brain Res. Inst. Niigata Univ.
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Nagano Takashi
Department Of Chemistry School Of Science And Graduate School Of Pharmaceutical Sciences The Univers
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Yamaguchi Tsuyoshi
Department Of Applied Physics Faculty Of Engineering Shizuoka University
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ICHIKAWA Tomio
Department of Applied Food Research, National Institute of Health and Nutrition
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Araki Kazuaki
Department of Molecular Neurobiology Brain Research Institute, Niigata University
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Kumanishi Toshiro
Department of Molecular Neurobiology Brain Research Institute, Niigata University
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