Development of GFAP-positive Cells and Reactive Changes Associated with Cystic Lesions in HTX Rat Brain
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概要
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HTX rat, a congenital hydrocephalic strain, develops ventricular dilatation and cystic cavities in the cerebral white matter after birth. To investigate the reactive changes in glial cells around these cavities, immunohistochemical staining for glial fibrillary acidic protein (GFAP), a specific marker protein of astrocytes, and bromodeoxyuridine (BrdU), a thymidine analogue, was carried out on 107 Wistar and HTX rat brains from birth to postnatal day (P) 26. Animals were divided into three groups: Group A, Wistar rats as normal controls; Group B, HTX rats with a normal structure or only mild ventricular dilatation without any lesion in the white matter; and Group C, HTX rats with severe ventricular dilatation and cyst formation in the white matter. Group B rats showed similar development of GFAP-positive (GFAP^+) cells to that in Group A rats, both morphologically and quantitatively. On the other hand, Group C rats showed definite structural changes in GFAP^+ cells around the cystic cavities from P5. These included enriched cytoplasm and thickened cell processes with increased GFAP expression, and enveloped most cyst walls from P10. However, quantitative examination of the percentage of GFAP^+ cells in Group C rats showed a similar developmental profile to those in Group A and B rats. Furthermore, the labeling index of BrdU-positive cells, indicating S-phase cells, in the white matter in Group C rats showed a similar decreasing pattern to that in Group A and B rats from P1 to P26. These results indicate that the GFAP^+ cells in HTX rats develop in a similar manner to those in Wistar rats, and that the reactive changes in the cyst walls occur immediately after the beginning of GFAP production and have similar structural and functional features of lesion repair to those in adult brain pathology. However, the reactive changes do not involve new cell proliferation.
- 1990-07-15
著者
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Abe Satoshi
Departments of Cardiovascular, Respiratory and Metabolic Medicine, Kagoshima University
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Abe Satoshi
Departments Of Cardiovascular Respiratory And Metabolic Medicine Kagoshima University
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YOSHIDA Yasuji
Department of Pathology Research institute for Brain and Blood Vesels
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KUMANISHI Toshiro
Department of Molecular Pathology, Brain Research Institute, Niigata University
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Yoshida Yasuji
Department Of Neuropathology Institute For Neurological Science Hirosaki University School Of Medici
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Yoshida Yasuji
Department Of Food And Nutrition Faculty Of Agriculture Kinki University
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KOYA Goyo
Department of Neuropathology, Hirosaki University School of Medicine
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Koya Goyo
Department Of Neuropathology Institute For Neurological Science Hirosaki University School Of Medici
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Koya Goyo
Department Of Neuropathology Hirosaki University School Of Medicine
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TAMAYAMA Kouki
Department of Neuropathology, Institute for Neurological Science, Hirosaki University School of Medi
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Kumanishi Toshiro
Department Of Molecular Neuropathology Brain Research Institute Niigata University
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Tamayama Kouki
Department Of Neuropathology Institute For Neurological Science Hirosaki University School Of Medici
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Abe Satoshi
Department Of Neuropathology Brain Research Institute Niigata University
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Abe Satoshi
Department Of Electrical And Communication Engineering Graduate School Of Engineering Tohoku Univers
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KUMANISHI Toshiro
Department of Neuropathology, Brain Research Institute, Niigata University
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Abe Satoshi
Department of Applied Chemistry, Faculty of Engineering, Yamagata University
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Kumanishi Toshiro
Department of Molecular Neurobiology Brain Research Institute, Niigata University
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