Hepatic Cytochrome P450 2E1 Level Rather Than Cecal Condition Contributes to Induction of Early Stage of the Alcoholic Liver Damage in Rats
スポンサーリンク
概要
- 論文の詳細を見る
Intestinal condition and ethanol toxicity have been discussed as predictors of alcoholic liver damage. In this study, we investigated the association of hepatic antioxidant enzymes and cecal condition, including intestinal bacteria estimated by terminal restriction fragment length polymorphism (T-RFLP), in the early stage of alcoholic fatty liver. Three liquid isocaloric diets, control (CT) diet, ethanol (ET) diet, or ethanol diet including modified beet fiber (MBF), were prepared and administered to rats for 4 weeks. At 4 weeks, the plasma alanine aminotransferase (ALT) levels in the ET group were higher and that in MBF groups tended to be higher than the CT group, but endotoxin was not detected in the portal vein in any of the samples. The hepatic thiobarbituric acid reactive substances (TBARS) concentration in the MBF group was higher than that in the CT group. Hepatic cytochrome P450 2E1 (CYP2E1) was induced in ethanol-fed rats. The hepatic catalase levels in the ET and MBF groups were lower than that in the CT group. The hepatic superoxide dismutase-2 (SOD-2) level did not differ among the groups. Plasma ALT level and/or hepatic TBARS level correlated positively with CYP2E1 and negatively with catalase level and SOD-2 level. Indicators of cecal condition, including the bacterial population estimated by T-RFLP, may not give any explanation for the hepatic damage. In conclusion, the hepatic CYP2E1 induced by ethanol, rather than the cecal conditions, may influence the early stage of alcoholic hepatic damage in rats; hepatic catalase may provide protective effects.
- 公益社団法人 日本薬学会の論文
著者
-
HASHIMOTO Naoto
Memuro Upland Farming Research Station, National Agricultural Research Center for Hokkaido Region
-
NODA Takahiro
Memuro Upland Farming Research Station, National Agricultural Research Center for Hokkaido Region
-
FUKUSHIMA Michihiro
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medici
-
SAITO Katsuichi
Memuro Upland Farming Research Station, National Agricultural Research Center for Hokkaido Region
-
Saito Katsuichi
Memuro Upland Farming Research Station National Agricultural Research Center For Hokkaido Region
-
Han Kyu-ho
Department Of Food Science Obihiro University Of Agriculture And Veterinary Medicine
-
Yamauchi Hiroaki
Memuro Research Station National Agricultural Research Center For Hokkaido Region Naro
-
Sekiguchi Hiroyuki
Memuro Upland Farming Research Station, National Agricultural Research Center for Hokkaido Region
-
Masunaka Akira
Memuro Upland Farming Research Station, National Agricultural Research Center for Hokkaido Region
-
Masunaka Akira
Memuro Research Station National Agricultural Research Center For Hokkaido Region
-
HAN Kyu-Ho
Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine
-
Saito Katsuichi
Memuro Research Station, National Agricultural Research Center for Hokkaido Region, National Agriculture and Food Research Organization
-
YAMAUCHI Hiroaki
Memuro Upland Farming Research Station, National Agricultural Research Center for Hokkaido Region
関連論文
- rDNA ITS Sequence of Rhizopus oryzae : Its Application to Classification and Identification of Lactic Acid Producers(Microbiology & Fermentation Technology)
- Endophytes as Producers of Xylanase
- Isolation, Screening and Phylogenetic Identification of Endophytes from Plants in Hokkaido Japan and Java Indonesia
- A Farinograph Study on Dough Characteristics of Mixtures of Wheat Flour and Potato Starches from Different Cultivars
- Effects of High-Molecular-Weight Glutenin Subunits on the Texture of Yellow Alkaline Noodles Using Near-Isogenic Lines
- Staling and Texture of Bread Prepared from New Japanese Bread Wheat Varieties with Slightly Low-Amylose Starch
- Effect of Natural Light Periods on Rutin, Free Amino Acid and Vitamin C Contents in the Sprouts of Common (Fagopyrum esculentum Moench) and Tartary (F. tataricum Gaertn.) Buckwheats
- Effect of White Wheat Bread Containing Sugar Beet Fiber on Serum Lipids and Hepatic mRNA in Rats Fed on a Cholesterol-Free Diet
- Hepatoprotective Effects of the Water Extract from Adzuki Bean Hulls on Acetaminophen-Induced Damage in Rat Liver
- Cholesterol Metabolism in Rat Is Affected by Protocatechuic Acid
- Resistant Starches of Beans Reduce the Serum Cholesterol Concentration in Rats
- Investigation of Gene Expressions Related to Cholesterol Metabolism in Rats Fed Diets Enriched in n-6 or n-3 Fatty Acid with a Cholesterol after Long-term Feeling Using Quantitative-competitive RT-PCR Analysis
- Effects of a Probiotic on the Lipid Metabolism of Cocks Fed on a Cholesterol-enriched Diet
- A Mixture of Organisms Affects Cholesterol Metabolism Together with Rat Cecal Flora
- Comparative Hypocholesterolemic Effects of Five Animal Oils in Cholesterol-fed Rats
- Effect of an Adzuki Bean Extract on Hepatic Anti-Oxidant Enzyme mRNAs in D-Galactosamine-Treated Rats
- Fat- and Cholesterol-Enriched Diet Feeding Affects Gene Expression Related to Cholesterol Metabolism in Rats
- Effects of the Lipid-Saccharide Complex and Unsaponifiable Matter from Sunflowers on Liver Lipid Metabolism and Intestinal Flora in Rats
- Effects of Sunflowers on Lipid Metabolism in Rats
- A Localized Route Discovery for On-Demand Routing Protocols in Event-Driven Wireless Sensor Networks(Network)
- Comparison of Amylomyces rouxii and Rhizopus oryzae in Lactic Acid Fermentation of Potato Pulp
- Molecular Cloning of the Gene Encoding the di-D-Fructofuranose 1,2':2,3' Dianhydride Hydrolysis Enzyme (DFA IIlase) from Arthrobacter sp. H65-7
- An Efficient Routing Optimization Scheme Using Proxy Home Router(Network)
- Red Potato Extract Protects from D-Galactosamine-induced Liver Injury in Rats
- Potato Pulps Lowered the Serum Cholesterol and Triglyceride Levels in Rats
- Hepatoprotective Effects of Purple Potato Extract against D-Galactosamine-Induced Liver Injury in Rats
- Improving the Utility of Potato Pulp for Bread-Making by Fermentation with Rhizopus oryzae
- Bread-Making Quality of Wheat/Rice Flour Blends
- The Pasting Properties of Flour and Starch in Wheat Grain Damaged by α-Amylase
- Potato and Soy Peptide Diets Modulate Lipid Metabolism in Rats
- Tartary Buckwheat Sprout Powder Lowers Plasma Cholesterol Level in Rats
- Anthocyanin-Rich Red Potato Flakes Affect Serum Lipid Peroxidation and Hepatic SOD mRNA Level in Rats
- Amylomyces rouxii Strain CBS 438.76 Affects Cholesterol Metabolism in Cholesterol-Fed Rats
- Bacterial Adjunct to Improve the Quality of Alkaline Noodles
- Microbial Demetallization of Crude Oil : Nickel Protoporphyrin Disodium as a Model Organo-Metallic Substrate
- Molecular Cloning and High-Level Expression in Escherichia coli of Fungal α-Galactosidase from Absidia corymbifera IFO 8084
- Effects of DFA IV in Rats : Calcium Absorption and Metabolism of DFA IV by Intestinal Microorganisms
- Molecular Cloning of Levan Fructotransferase Gene from Arthrobacter nicotinovorans GS-9 and Its Expression in Escherichia coli
- Purification of Levan Fructotransferase from Arthrobacter nicotinovorans GS-9 and Production of DFA IV from Levan by the Enzyme
- An LMW-s Glutenin Gene of a Hard Red Winter Wheat is Similar to an LMW-s Gene of a Canadian Western Extra-strong Wheat
- Ingestion of Gelatinized Potato Starch Containing a High Level of Phosphorus Decreases Serum and Liver Lipids in Rats
- Conversion of Beet Molasses and Cheese Whey into Fatty Acid Methyl Esters by the Yeast Cryptococcus curvatus
- Correlation between the Presence of Ubiquitin Conjugated Protein Phosphatase Inhibitor 1 and Postmortem Muscle Glycogen Metabolism
- Potato and Soy Peptide Diets Modulate Lipid Metabolism in Rats
- Effect of White Wheat Bread Containing Sugar Beet Fiber on Serum Lipids and Hepatic mRNA in Rats Fed on a Cholesterol-Free Diet
- Effect of Fermented Bean Paste on Serum Lipids in Rats Fed a Cholesterol-Free Diet
- Anthocyanin-Rich Red Potato Flakes Affect Serum Lipid Peroxidation and Hepatic SOD mRNA Level in Rats
- Characterization of an Alternative Baking Strain of Saccharomyces cerevisiae Isolated from Fermented Cherry Fruits by the Analysis of SUC2 Gene
- Hepatic Cytochrome P450 2E1 Level Rather Than Cecal Condition Contributes to Induction of Early Stage of the Alcoholic Liver Damage in Rats
- Amelioration of D-Galactosamine-Induced Acute Liver Injury in Rats by Dietary Supplementation with Betaine Derived from Sugar Beet Molasses
- Visualization of Ralstonia solanacearum cells during biocontrol of bacterial wilt disease in tomato with Pythium oligandrum
- Effects of Dietary Supplementation with Betaine on a Nonalcoholic Steatohepatitis (NASH) Mouse Model
- Japanese Butterbur (Petasites japonicus) Leaves Increase Hepatic Oxidative Stress in Male Rats
- Raw Chinese Yam (Dioscorea opposita) Promotes Cecal Fermentation and Reduces Plasma Non-HDL Cholesterol Concentration in Rats
- Effects of Anthocyanin-rich Colored Potato Flakes on Lipid Oxidation, Instrumental Color Evaluation and Sensory Characteristics in Cooked Pork Sausages
- Dietary L-Cysteine Improves the Antioxidative Potential and Lipid Metabolism in Rats Fed a Normal Diet
- Effects of Dietary Supplementation with Betaine on a Nonalcoholic Steatohepatitis (NASH) Mouse Model
- Japanese Butterbur (Petasites japonicus) Leaves Increase Hepatic Oxidative Stress in Male Rats
- Resistant Starches of Beans Reduce the Serum Cholesterol Concentration in Rats
- Effect of Potato Ethanol Residue on Rat Plasma Cholesterol Levels
- Comparison of the Effects of Longer Chain Inulins with Different Degrees of Polymerization on Colonic Fermentation in a Mixed Culture of Swine Fecal Bacteria