A soluble flavonoid-glycoside, alphaG-rutin, is absorbed as glycosides in the isolated gastric and intestinal mucosa.
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概要
- 論文の詳細を見る
We investigated the absorption and metabolism of the highly soluble quercetin glycoside αG-rutin, a glucose adduct of insoluble rutin, using the isolated mucosa of the rat stomach and intestines equipped with the Ussing chamber. αG-rutin and rutin appeared in the serosal sides of the gastric body and all the intestinal mucosa after the addition of αG-rutin (1 mM) to the mucosal fluid. The degree of αG-rutin appearance was much lower in the gastric fundus than in the other parts. Quercetin was not found in the mucosal fluid of any mucosal specimen. The concentrations (μM) of αG-rutin and rutin in the serosal fluid as a result of transport from the mucosal side increased time-dependently and linearly with mucosal αG-rutin concentration (1, 10 or 100 mM). The highest transport was shown in the ileal mucosa. These results indicate that αG-rutin is partly hydrolyzed to rutin through the intestine and absorbed as such.
- Japan Society for Bioscience, Biotechnology, and Agrochemistryの論文
- 2004-09-23
著者
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HARA HIROSHI
Laboratory of Nutritional Biochemistry, Graduate School of Agriculture, Hokkaido University
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CHIJI Hideyuki
Department of Food Science and Human Nutrition, Faculty of Human Ecology, Fuji Women's College
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Hara H
Lab. Of Nutritional Biochemistry Div. Of Applied Bioscience Graduate School Of Agriculture Hokkaido
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Matsumoto Megumi
Laboratory of Nutritional Biochemistry, Division of Applied Bioscience, Graduate School of Agricultu
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MATSUKAWA Noriko
Department of Food Science and Human Nutrition, Faculty of Human Life Science, Fuji Women's Universi
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MINEO Hitoshi
Department of Food Science and Human Nutrition, Faculty of Human Life Science, Fuji Women's Universi
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Chiji Hideyuki
Department Of Food Science And Human Nutrition Faculty Of Human Life Science Fuji Women's Unive
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Chiji Hideyuki
Department Of Agricultural Chemistry Faculty Of Agriculture Hokkaido University
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Matsumoto Megumi
Department Of Food Science And Human Nutrition Faculty Of Human Life Science Fuji Women's Unive
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Hara Hiroshi
Toxicology Laboratory Chugai Pharmaceutical Co. Ltd.
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MATSUKAWA Noriko
Kyoto Institute of Nutrition and Pathology, Inc.
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Mineo Hitoshi
Div. Of Applied Bioscience Graduate School Of Agriculture Hokkaido Univ. Kita-9 Nishi-9 Sapporo Hokk
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Matsumoto Megumi
Laboratory Of Nutritional Biochemistry Division Of Applied Bioscience Graduate School Of Agriculture
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Matsukawa Noriko
Kyoto Institute Of Nutrition And Pathology Inc.
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Hara Hiroshi
Laboratory Of Nutritional Biochemistry Division Of Applied Bioscience Graduate School Of Agriculture
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