A partially degraded product of phytate suppresses the proliferation of HCT116 colorectal cancer cells
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概要
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Phytate, myo-inositol hexaphosphate (IP6), has been shown to possess anti-carcinogenic qualities. IP6 appears to be partially digested in the digestive tract and degraded into inositol di, tri-, and tetra-phosphate (IP2, IP3, and IP4). The present study investigated whether IP3-rich phytate hydrolysate (IP3-RPH), a partially degraded product from phytate plays a role in the suppression of cell proliferation using an HCT116 colon carcinoma cell line. IP3-RPH suppresses cell proliferation as well as IP6, and the suppression activity of IP3-RPH was higher than that of IP6. Suppression modes clearly differed between IP3-RPH and IP6. Our findings suggest that partially degraded IP6 products are responsible for the suppression of colon carcinogenesis by IP6.
- 2011-04-15
著者
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Hara H
Lab. Of Nutritional Biochemistry Div. Of Applied Bioscience Graduate School Of Agriculture Hokkaido
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Hara Hiroshi
Toxicology Laboratory Chugai Pharmaceutical Co. Ltd.
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Lee Jin-ha
Research Faculty Of Agriculture Hokkaido University
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