Pork peptone stimulates cholecystokinin secretion from enteroendocrine cells and suppresses appetite in rats.

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概要

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• We found that soybean β-conglycinin peptone (BconP) suppresses food intake through cholecystokinin (CCK) release from enteroendocrine cells in association with binding of the peptone to rat small intestinal brush border membrane (BBM). The aim of the present study was to find new appetite suppressing peptides. Peptones from chicken, pork, beef, beef liver, and egg white were examined for activities to bind with rat BBM, CCK-release from enteroendocrine cell line STC-1, and induce satiety in rats. Chicken and pork peptone (ChickP and PorkP) bound to BBM with highest ability as evaluated with a surface plasmon biosensor. PorkP and ChickP released CCK in higher amounts than BconP from STC-1 cells dose-dependently, with highest stimulation by PorkP. An orogastric preload of PorkP, but not ChickP, suppressed food intake similarly to BconP, dose-dependently. These results suggest that PorkP interacts directly with the small intestinal CCK cells to release CCK, and that it suppresses appetite in rats.

• Japan Science and Technology Information Aggregator, Electronicの論文
• 2006-08-23

著者

• ASANO Kozo

  Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University

• Hara Hiroshi

  Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University

• Asano Kozo

  Lab. Of Applied Microbiology Graduate School Of Agriculture Hokkaido Univ. Kita-9 Nishi-9 Sapporo 06

• Asano Kozo

  北海道大学農学部応用生命科学専攻

• Asano Kozo

  Division Of Applied Bioscience Graduate School Of Agriculture Hokkaido University

• Hara H

  Lab. Of Nutritional Biochemistry Div. Of Applied Bioscience Graduate School Of Agriculture Hokkaido

• Nishi Takashi

  Division Of Applied Bioscience Graduate School Of Agriculture Hokkaido University

• Miyashita Kyoko

  Division Of Applied Bioscience Graduate School Of Agriculture Hokkaido University

• Hara Hiroshi

  Toxicology Laboratory Chugai Pharmaceutical Co. Ltd.

• SUFIAN MKNB

  Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University

• HIRA Tohru

  Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University

• Hira Tohru

  Division Of Applied Bioscience Graduate School Of Agriculture Hokkaido University

• Sufian Mknb

  Division Of Applied Bioscience Graduate School Of Agriculture Hokkaido University

• HIRA Tohru

  Research Faculty of Agriculture, Hokkaido University

• Hira Tohru

  Research Faculty Of Agriculture Hokkaido University

• Hara Hiroshi

  Division Of Applied Bioscience Graduate School Of Agriculture Hokkaido University

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