Suppressive effect of antibiotics on colony formation from human megakaryocyte progenitors (CFU-M) and granulocyte-macrophage progenitors (CFU-GM).
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概要
- 論文の詳細を見る
β-Lactam antibiotics, moxalactam (LMOX), cefotaxime (CTX), flomoxef (FMOX), cefamandole (CMD), carbenicillin (CBPC) and sulbenicillin (SBPC), suppressed colony formation from human megakaryocyte progenitors (CFU-M) and granulocyte-macrophage progenitors (CFU-GM) dose-dependently. The suppressive potencies for both progenitors were weakest for CBPC and SBPC, moderate for LMOX and FMOX, and strongest for CMD and CTX. The stainability of glycoprotein IIb/IIIa complex in the megakaryocyte colonies by the monoclonal antibody was decreased by LMOX and CTX. These data suggest that β-lactam antibiotics directly suppress proliferation of CFU-M and CFU-GM.
- 公益社団法人 日本薬理学会の論文
著者
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Uchida Kiyohisa
Shionogi Aburahi Laboratories
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Hara Hiroshi
Division Of Applied Bioscience Graduate School Of Agriculture Hokkaido University
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MARUYAMA Toshiyuki
Shionogi Research Laboratories
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