Relationships between Hematological Recovery and Overall Survival in Older Adults Undergoing Allogeneic Bone Marrow Transplantation
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概要
- 論文の詳細を見る
Objective The advancement of hematopoietic stem cell transplantation techniques and the increase in frequency of hematological malignancy in older patients are expected to expand the indications to include more elderly patients. We investigated the problem of allogeneic bone marrow transplantation (allo-BMT) in patients over 40 years old.Patients and Methods We retrospectively analyzed 21 consecutive patients (13 males and 8 females) over 40 years old who underwent allo-BMT at our center during the past 12 years.ResultsThe patients had a median age of 46 years, and 5 patients were over 50 years old. There were 8 cases of acute myelogenous leukemia (AML), 5 cases of acute lymphocytic leukemia (ALL), 6 cases of chronic myelogenous leukemia (CML) and 2 cases of myelodysplastic syndrome (MDS). The 3-year overall survival rate was 43.0%. Overall survival was associated with recovery of platelets in less than 30 days and recovery of neutrophil counts in less than 15 days. We did not observe any severe graft-versus-host disease (GVHD) or regimen-related toxicities. Twelve patients died of transplantation-related diseases.Conclusion A faster recovery of the neutrophil and platelet counts was significantly associated with overall survival. Decreasing transplantation-related death, particularly by infection control, in allo-BMT in patients over age 40 is an important problem.
- 社団法人 日本内科学会の論文
- 2005-01-01
著者
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OKADA Masaya
Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine
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Hara Hiroshi
Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University
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TABATA Masahiko
Department of Pediatrics, Kiryu Kosei General Hospital
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岡田 昌也
兵庫医科大学総合内科学血液・腫瘍科
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SATAKE Atsushi
Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine
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Okada Masaya
Division Of Hematology And Oncology Department Of Internal Medicine Hyogo College Of Medicine
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Okada Masaya
兵庫医科大学 総合内科
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Okada Masaya
Division Of Hematology Department Of Internal Medicine Hyogo College Of Medicine
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Okada Masaya
Hyogo Coll. Medicine Nishinomiya Jpn
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KAI Shunro
Department of Transfusion Medicine, Hyogo College of Medicine
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MISAWA Mahito
Division of Hematology, Department of Internal Medicine, Institute for Advanced Medical Sciences, Hy
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WAKAE Takeshi
Division of Hematology, Department of Internal Medicine, Institute for Advanced Medical Sciences, Hy
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TODA Akinari
Division of Hematology, Department of Internal Medicine, Institute for Advanced Medical Sciences, Hy
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TAKATSUKA Hiroyuki
Division of Hematology, Department of Internal Medicine, Institute for Advanced Medical Sciences, Hy
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ITSUKUMA Takeyoshi
Division of Hematology, Department of Internal Medicine, Institute for Advanced Medical Sciences, Hy
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NISHIOKA Keisuke
Division of Hematology, Department of Internal Medicine, Institute for Advanced Medical Sciences, Hy
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HARA Hiroshi
Uegahara Hospital
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岡田 昌也
兵庫医科大学病院血液内科
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CHIN Meishu
Department of Transfusion Medicine, Hyogo College of Medicine
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TANAKA Hidehisa
Department of Transfusion Medicine, Hyogo College of Medicine
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YAMAGUCHI Masao
Division of Hematology and Oncology, Department of Internal Medicine, Hyogo College of Medicine
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TAKATSUKA Hiroyuki
Koito Manufacturing Co. Ltd
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Takatsuka Hiroyuki
Division Of Hematology And Oncology Department Of Internal Medicine Hyogo College Of Medicine
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Kai Shunro
Division Of Transfusion Medicine Hyogo College Of Medicine
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Kai Shunro
Department Of Transfusion Medicine Hyogo College Of Medicine
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Chin Meishu
Department Of Transfusion Medicine Hyogo College Of Medicine
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Toda Akinari
Division Of Hematology And Oncology Department Of Internal Medicine Hyogo College Of Medicine
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Wakae Takeshi
Division Of Hematology And Oncology Department Of Internal Medicine Hyogo College Of Medicine
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Misawa Mahito
Division Of Hematology-oncology Department Of Internal Medicine Hyogo College Of Medicine
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Satake Atsushi
Division Of Hematology And Oncology Department Of Internal Medicine Hyogo College Of Medicine
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Tabata Masahiko
Department Of Pathology Nihon University School Of Medicine
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Tabata Masahiko
Department Of Transfusion Medicine Hyogo College Of Medicine
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Tanaka Hidehisa
Department Of Immunology And Medical Zoology Hyogo College Of Medicine
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Tanaka Hidehisa
Department Of Transfusion Medicine Hyogo College Of Medicine
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Itsukuma Takeyoshi
Division Of Hematology-oncology Department Of Internal Medicine Hyogo College Of Medicine
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Yamaguchi Masao
Division Of Hematology And Oncology Department Of Internal Medicine Hyogo College Of Medicine
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Hara Hiroshi
Division Of Applied Bioscience Graduate School Of Agriculture Hokkaido University
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Nishioka Keisuke
Division Of Hematology And Oncology Department Of Internal Medicine Hyogo College Of Medicine
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TABATA Masahiko
Department of Fermentation Technology, Hiroshima University
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