Efficacy and safety of nilotinib in Japanese patients with imatinib-resistant or -intolerant Ph+ CML or relapsed/refractory Ph+ ALL : a 36-month analysis of a phase I and II study
スポンサーリンク
概要
- 論文の詳細を見る
- 2012-04-01
著者
-
NAOE Tomoki
Department of Hematology and Oncology, Nagoya University Graduate School of Medicine
-
MORI Shinichiro
Hematopoietic Stem Cell Transplantation Unit, National Cancer Center Hospital
-
Morishima Y
Department Of Hematology Kinki University School Of Medicine
-
Katayama Y
Division Of Hematology Saitama Medical Center Jichi Medical University
-
Moriwaki Yuji
長崎大学大学院医歯薬学総合研究科附属原爆後障害医療研究施設 分子治療研究分野
-
岡田 昌也
兵庫医科大学総合内科学血液・腫瘍科
-
Tsuboi Naoya
Department Of Hematology And Oncology Nagoya University Graduate School Of Medicine
-
Tomonari Akira
東京大学医科学研究所附属病院 血液腫瘍内科
-
Tomonari Akira
Department Of Hematology/oncology The Institute Of Medical Science The University Of Tokyo
-
Tomonari Akira
Department Of Hematology/oncology
-
MEGURO KUNIAKI
National Sendai Hospital
-
Minauchi Koichiro
Second Department Of Medicine Hokkaido University Graduate School Of Medicine
-
Kobayashi Y
Hematology And Stem Cell Transplantation Divisions National Cancer Center Hospital
-
Usubuchi Noriko
国立がんセンター中央病院
-
Usubuchi Noriko
Hematology And Oncology Division National Cancer Center Hospital East
-
Uike Naokuni
Department Of Hematology National Kyushu Cancer Center Hospital
-
NAGAI Tadashi
Jichi Medical School
-
NAOE Tomoki
Nagoya University
-
MIYAZAKI Yasushi
Nagasaki University
-
Kagami Yoshitoyo
東海大学 医学部血液･腫瘍内科
-
Kagami Yoshitoyo
名古屋大学医学部附属病院 病理部
-
Kagami Yoshitoyo
東京大学医科学研究所ヒトゲノム解析センター
-
Okada Masaya
Division Of Hematology And Oncology Department Of Internal Medicine Hyogo College Of Medicine
-
Okada Masaya
Division Of Hematology Department Of Internal Medicine Hyogo College Of Medicine
-
Uoshima Nobuhiko
京都府立医科大学 血液･腫瘍内科学
-
Uoshima Nobuhiko
Matsushita Memorial Hospital Moriguchi Jpn
-
Uoshima Nobuhiko
1st Department Of Internal Medicine Kyoto Prefectureal University Of Medicine
-
Naoe Tomoki
名古屋大学 医学系研究科血液･腫瘍内科学
-
Usui Noriko
東京慈恵会医科大学附属病院 中央検査部
-
Usui N
Division Of Hematology And Oncology Department Of Medicine Jikei University
-
Okamoto Shin-ichiro
国立がんセンター中央病院 血液内科
-
Ohnishi K
Third Department Of Internal Medicine Hamamatsu University School Of Medicine
-
Ohnishi Kazunori
東北大学病院 血液･免疫科
-
NAKASEKO Chiaki
Chiba University Hospital
-
TOJO Arinobu
The Institute of Medical Science, The University of Tokyo
-
USUKI Kensuke
NTT Kanto Medical Center
-
KOBAYASHI Yukio
National Cancer Center Hospital
-
KAWAGUCHI Tatsuya
Kumamoto University Hospital
-
TANAKA Hideo
Hiroshima University Hospital
-
MIYAMURA Koichi
Japanese Red Cross Nagoya First Hospital
-
AMAGASAKI Taro
Novartis Pharma Japan
-
Yamamoto Kazuhito
愛知県がんセンター中央病院 血液･細胞療法部
-
Kanakura Yuzuru
大阪大学 医学系研究科心臓血管外科
-
Usui N
Jikei University Hospital
-
Kamiya Yoshikazu
Department Of Hematology Meitetsu Hospital
-
Kamiya Yoshikazu
愛知がんセンター 血液･細胞療法部
-
Matsumoto-mishima Yuko
癌研究会癌化学療法センター 臨床研究部
-
Meguro Kuniaki
東北大学 医学部分子診断学
-
Kawase Yoshiaki
Department Of Internal Medicine Japanese Red Cross Nagoya First Hospital
-
Odagiri Keiichi
Department Of Medicine Hamamatsu Red Cross Hospital
-
Matsuno Y
Department Of Surgical Pathology Hokkaido University Hospital
-
Matsuno Yoshihiro
Department Of Chemotherapy Tokyo Metropolitan Cancer And Infectious Diseases Center Komagome Hospita
-
Okada Masaya
Hyogo Coll. Medicine Nishinomiya Jpn
-
IWATO Koji
Hiroshima Red Cross Hospital and Atomic-Bomb Survivors Hospital
-
Uike Naokuni
Department Of Hemato-oncology Kyushu Cancer Center
-
Tojo A
Univ. Tokyo Tokyo Jpn
-
Usuki Kensuke
Division Of Hematology Ntt Kanto Medical Center
-
Ohshima Koichi
First Department Of Pathology Fukuoka University
-
Miyamura Koichi
Department Of Hematology And Rheumatology Tohoku University Graduate School Of Medicine
-
Miyamoto Ken-ichi
Department Of Hematology Japanese Red Cross Nagoya First Hospital
-
Oshimi Kazuo
Department Of Hematology Juntendo University Tokyo
-
Kobayashi Yukio
Hematology And Stem Cell Transplantation Divisions National Cancer Center Hospital
-
Morishima Yasuo
Department Of Hematology And Cell Therapy Aichi Cancer Center Central Hospital
-
Okamoto Shin-ichiro
Division Of Hematology Department Of Medicine Keio University School Of Medicine
-
Matsuo Yuji
Department Of Hematology And Molecular Medicine Unit Atomic Bomb Disease Institute Nagasaki Universi
-
Miyamura Koichi
東北大学 医学系研究科血液･免疫病学分野
-
Morishima Yasuo
Department Of Hematology And Chemotherapy
-
Usui Noriko
Jikei Univ. Hospital Tokyo Jpn
-
Usui Noriko
The "lung Injury By Bortezomib" Joint Committee Of The Japanese Society Of Hematology And
-
Oshimi Kazuo
Department Of Internal Medicine Hamamatsu University School Of Medicine
-
Murai Yoshiro
Department Of Hematology Tama Hokubu Medical Center
-
Tomita Akihiro
First Department Of Internal Medicine Nagoya University School Of Medicine
-
Miyazawa Keisuke
Department Of Hematology Tokyo Medical University
-
Katayama Yoshio
Division Of Hematology Saitama Medical Center Jichi Medical University
-
岡田 昌也
兵庫医科大学病院血液内科
-
Katayama Yoshio
Hematology/oncology Department Of Medicine Kobe University Graduate School Of Medicine
-
Masaki Y
Department Of Hematology And Immunology Kanazawa Medical University
-
Morishita Yoshihisa
Department Of Hematology And Oncology Ja Aichi Showa Hospital
-
Morita Yasuyoshi
Kinki Univ. School Of Medicine Osaka Jpn
-
Kagami Yoshitoyo
Department Of Pathology School Of Medicine Kurume University
-
Matsumoto Yosuke
Department Of Molecular Hematology And Oncology Graduate School Of Medical Science Kyoto Prefectural
-
Ohnishi Kazunori
The "lung Injury By Bortezomib" Joint Committee Of The Japanese Society Of Hematology And
-
Okamoto Shinichiro
Keio Univ. School Of Medicine Tokyo Jpn
-
Ohnishi Kazunori
Department Of Internal Medicine Hamamatsu University School Of Medicine
-
Tadashi Nagai
Division Of Hematology Department Of Medicine Jichi Medical University
-
Maeda Yasuhiro
Kinki Univ. School Of Medicine Osaka‐sayama Jpn
-
Yasukawa Masaki
Department Of Bioregulatory Medicine Ehime University
-
Tojo Arinobu
The Institute Of Medical Science The University Of Tokyo
-
Kinoshita Tomohiro
Department Of Hematology Nagoya University School Of Medicine
-
Kawaguchi Tatsuya
Kumamoto Univ. Graduate School Of Medical Sci. Kumamoto Jpn
-
Takeyama K
National Cancer Center Hospital Tokyo Jpn
-
Miki Yoshio
Department Of Human Genome Analysis Cancer Chemotherapy Center Japanese Foundation For Cancer Resear
-
Usui Noriko
Division Of Oncology & Hematology Department Of Internal Medicine The Jikei University School Of
-
Kawai Yasukazu
Department Of Hematology Japanese Red Cross Nagoya First Hospital
-
Naruse T
Department Of Hematology And Oncology Nagoya University Graduate School Of Medicine
-
Katayama Yoshio
Second Department Of Internal Medicine Okayama University Medical School
-
Tojo Arinobu
Univ. Tokyo Tokyo Jpn
-
Yano Kunio
県西部浜松医療センター
-
Kimura Yukihiko
First Department Of Internal Medicine Tokyo Medical College
-
Takeshita Akihiro
Hamamatsu Univ. School Of Medicine Shizuoka Jpn
-
Morishima Yasuo
Department Of Pathology And Oncology Institute Of Medical Science University Of Tokyo
-
Kimura Yoshizo
Department Of Pathology School Of Medicine Kurume University
-
Mori Shinichiro
Department Of Hematology And Oncology Kansai Medical University Hirakata Hospital
-
Tanaka Hideo
Hiroshima Univ. Hospital Hiroshima Jpn
-
Ohnishi Kazunori
Shikoku National Hospital Matsuyama Jpn
-
Nakano Tatsunori
Second Departmant Of Medicine Nagoya City University Medical School
-
Miyazaki Koji
Department Of Hematology Kitasato University Hospital
-
Ohyashiki Kazuma
Tokyo Medical Univ. Tokyo Jpn
-
MATSUDA Akira
International Medical Center, Saitama Medical University
-
ORITANI Kenji
Osaka University Hospital
-
USUI Noriko
The Jikei University Daisan Hospital
-
WANAJO Aira
Novartis Pharma Japan
-
Mikami Yuzuru
Department Of Hematology And Cell Therapy Aichi Cancer Center Hospital
-
OKAMOTO Shin-ichiro
Keio University Hospital
-
TAKAHASHI Naoto
Jichi Medical University Hospital
関連論文
- Allogeneic stem cell transplantation versus chemotherapy as post-remission therapy for intermediate or poor risk adult acute myeloid leukemia : results of the JALSG AML97 study
- Randomized trial of response-oriented individualized versus fixed-schedule induction chemotherapy with idarubicin and cytarabine in adult acute myeloid leukemia : the JALSG AML95 study
- Comparative analysis of remission induction therapy for high-risk MDS and AML progressed from MDS in the MDS200 study of Japan Adult Leukemia Study Group
- Interlaboratory Comparison of Quantitative RT-PCR Based Detection for Minimal Residual Disease in Leukemias : A Standardization Approach in Japan
- Successful treatment of minimal residual disease-positive Philadelphia chromosome-positive acute lymphoblastic leukemia with imatinib followed by reduced-intensity unrelated cord blood transplantation after allogeneic peripheral blood stein cell transplan
- Prospective trial of high-dose chemotherapy followed by infusions of peripheral blood stem cells and dose-escalated donor lymphocytes for relapsed leukemia after allogeneic stem cell transplantation
- Histological and immunophenotypic changes in 59 cases of B-cell non-Hodgkin's lymphoma after rituximab therapy
- Diffuse large B-cell lymphoma after transformation from low-grade follicular lymphoma : morphological, immunohistochemical, and FISH analyses
- Phase II study of tacrolimus and methotrexate for prophylaxis of acute graft-versus-host disease after HLA-A, B, and DRB1 genotypically mismatched unrelated bone marrow transplantation among Japanese patients
- Promoter Hypermethylation of the DNA-Repair Gene O^6-Methylguanine-DNA Methyltransferase and p53 Mutation in Diffuse Large B-Cell Lymphoma
- Loss of O^6-Methylguanine-DNA Methyltransferase Protein Expression Is a Favorable Prognostic Marker in Diffuse Large B-Cell Lymphoma
- Outcome of allogeneic bone marrow transplantation from unrelated donors for adult Philadelphia chromosome-negative acute lymphocytic leukemia in first complete-remission
- Linkage of expression of chemokine receptors (CXCR3 and CCR4) and cytotoxic molecules in peripheral T cell lymphoma, not otherwise specified and ALK-negative anaplastic large cell lymphoma
- Management of infection in patients with acute leukemia during chemotherapy in Japan : questionnaire analysis by the Japan Adult Leukemia Study Group
- A Phase I/II study of nilotinib in Japanese patients with imatinib-resistant or -intolerant Ph+ CML or relapsed/refractory Ph+ ALL
- Dose Modification of Imatinib by Monitoring the Level of BCR-ABL Transcript in Chronic Myelogenous Leukemia
- Imatinib Mesylate in Conjunction with Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Philadelphia Chromosome Positive Leukemias : Report of 4 Cases
- Detection of Clone-Specific Immunoglobulin Heavy Chain Genes in the Bone Marrow of B-cell-Lineage Lymphoma after Treatment
- High Expression of YB-1 Gene in Erythroid Cells in Patients with Refractory Anemia
- Donor cell leukemia after allogeneic peripheral blood stem cell transplantation : a case report and literature review
- Imatinib for newly diagnosed chronic-phase chronic myeloid leukemia : results of a prospective study in Japan
- The clinical characteristics of CD7^+ CD56^+ acute myeloid leukemias other than M0
- Definite diagnosis in Japanese patients with protein C deficiency by identification of causative PROC mutations
- Phase I/II study of humanized anti-CD33 antibody conjugated with calicheamicin, gemtuzumab ozogamicin, in relapsed or refractory acute myeloid leukemia : final results of Japanese multicenter cooperative study
- Retention but significant reduction of BCR-ABL transcript in hematopoietic stem cells in chronic myelogenous leukemia after imatinib therapy
- Mutational analysis of SOS1 gene in acute myeloid leukemia
- Clinical significance of minimal residual disease in patients with t(8;21) acute myeloid leukemia in Japan
- Evaluation of organ involvement in intravascular large B-cell lymphoma by ^F-fluorodeoxyglucose positron emission tomography
- Identification of amino acid residues responsible for von Willebrand factor binding to sulfatide by charged-to-alanine-scanning mutagenesis
- Sustained Remission after Rituximab-containing Chemotherapy for Intravascular Large B-cell Lymphoma
- Hematopoietic stem cell transplantation for acute promyelocytic leukemia in second or third complete remission : a retrospective analysis in the Nagoya Blood and Marrow Transplantation Group
- Diagnosis of acute myeloid leukemia according to the WHO classification in the Japan Adult Leukemia Study Group AML-97 protocol
- Wilms' tumor 1 message and protein expression in bone marrow failure syndrome and acute leukemia
- Epigenetic Regulation of CD20 Protein Expression in a Novel B-Cell Lymphoma Cell Line, RRBL1, Established from a Patient Treated Repeatedly with Rituximab-Containing Chemotherapy
- BMI-1 Is Highly Expressed in M0-Subtype Acute Myeloid Leukemia
- Successful Treatment with Imatinib Mesylate of a CML Patient in Megakaryoblastic Crisis with Severe Fibrosis
- Comparison of leukopenia between cytarabine and behenoyl cytarabine in JALSG AML-89 consolidation therapy
- Safety and Efficacy of Autologous Progenitor Cell Transplantation for Therapeutic Angiogenesis in Patients With Critical Limb Ischemia
- Downregulation of microRNAs-143 and -145 in B-cell malignancies
- let-7 MicroRNA Functions as a Potential Growth Suppressor in Human Colon Cancer Cells(Molecular and Cell Biology)
- A Case of Interstitial Pneumonia Induced by Rituximab Therapy
- Infectious complications during remission induction therapy in 577 patients with acute myeloid leukemia in the Japan Adult Leukemia Study Group studies between 1987 and 1991
- Chemical Speciation of Arsenic Species in Human Blood Serum by Liquid Chromatography Using a Phosphatidylcholine-Coated ODS Column with Detection by ICP-MS
- Central nervous system involvement in intravascular large B-cell lymphoma : A retrospective analysis of 109 patients
- Establishment of a Stroma-Dependent Human Acute Myelomonocytic Leukemia Cell Line, NAMO-2, with FLT3 Tandem Duplication
- Recurrent Intramural Hematoma of the Small Intestine in a Severe Hemophilia A Patient with a High Titer of Factor VIII Inhibitor : A Case Report and Review of the Literature
- High Titer of ADAMTS13 Inhibitor Associated with Thrombotic Microangiopathy of the Gut and Skeletal Muscle after Allogeneic Hematopoietic Stem Cell Transplantation
- Apoptotic Cytotoxic Effects of a Histone Deacetylase Inhibitor, FK228, on Malignant Lymphoid Cells
- A phase II, open-label, sequential-cohort, dose-escalation study of romiplostim in Japanese patients with chronic immune thrombocytopenic purpura
- Interaction of von Willebrand Factor with the Extracellular Matrix and Glycocalicin under Static Conditions^1
- Fludarabine- and Cyclophosphamide-Based Nonmyelobalative Conditioning Regimen for Transplantation of Chronic Granulomatous Disease : Possible Correlation with Prolonged Pure Red Cell Aplasia
- Nucleotide Alteration of Retinoblastoma Protein-Interacting Zinc Finger Gene, RIZ, in Human Leukemia
- Clinical features of adult acute leukemia with 11q23 abnormalities in Japan : a co-operative multicenter study
- Long-term Follow-up of 14 Patients with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia following Autologous Bone Marrow Transplantation in First Complete Remission
- Recent advances in the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia
- Spontaneous regression of aleukemic leukemia cutis harboring a NPM/RARA fusion gene in an infant with cutaneous mastosytosis
- A safety, pharmacokinetic and pharmacodynamic investigation of deferasirox (Exjade^【○!R】, ICL670) in patients with transfusion-dependent anemias and iron-overload : a Phase I study in Japan
- Biology, Clinical Relevance, and Molecularly Targeted Therapy in Acute Leukemia with FLT3 Mutation
- Nucleophosmin : A versatile molecule associated with hematological malignancies
- Mechanism-based Therapy for Leukemia: A Lesson from Atra Therapy
- Karyotypically independent clones with del(11q) and trisomy 10 in acute myeloid leukemia : trisomy 10 may appear as an additional change
- Antitumor effect of arsenic trioxide in murine xenograft model
- Successful Nonmyeloablative Bone Marrow Transplantation for Leukocyte Adhesion Deficiency Type I from an Unrelated Donor
- Significance of Decreased Plasma D-Dimer Levels following Lipopolysaccharide-Induced Disseminated Intravascular Coagulation in Rats
- Recombinant adeno-associated virus-mediated gene transfer into human leukemia cell lines
- Decreased risk of acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation in patients with the 5,10-methylenetetrahydrofolate reductase 677TT genotype
- Serologically HLA-DR-Mismatched Unrelated Donors Might Provide a Valuable Alternative in Allogeneic Transplantation : Experience from a Single Japanese Institution
- Stable Engraftment after a Conditioning Regimen with Fludarabine and Melphalan for Bone Marrow Transplantation from an Unrelated Donor
- Severe Hypercholesterolemia Associated with Decreased Hepatic Triglyceride Lipase Activity and Pseudohyponatremia in Patients after Allogeneic Stem Cell Transplantation
- Quality of Life in Adult Patients after Bone Marrow Transplantation
- Irrespective of CD34 expression, lineage-committed cell fraction reconstitutes and re-establishes transformed Philadelphia chromosome-positive leukemia in NOD/SCID/IL-2Rγc^ mice
- Severe hemophilia A in a Japanese female caused by an F8-intron 22 inversion associated with skewed X chromosome inactivation
- Classic Polyarteritis Nodosa Presenting Rare Clinical Manifestations in a Patient with Hemophilia A
- CD137-guided isolation and expansion of antigen-specific CD8 cells for potential use in adoptive immunotherapy
- Ectopic Expression of MAFB Gene in Human Myeloma Cells Carrying (14;20)(q32;q11) Chromosomal Translocations
- Acute myeloid leukemia in the elderly : 159 Nagoya case studies
- Sustained activation of c-jun-N-terminal kinase plays a critical role in arsenic trioxide-induced cell apoptosis in multiple myeloma cell lines
- Toxic effects of arsenic (As^) and other metal ions on acute promelocytic leukemia cells
- Immunoglobulin Variable Region Structure and B-Cell Malignancies
- Feasibility of salvage chemotherapy for refractory or relapsed non-Hodgkin's lymphoma with two topoisomerase II inhibitors, MST-16 and VP-16
- Immunoaffinity Purification and Characterization of CACGTG Sequence-Binding Proteins from Cultured Mammalian Cells Using an Anti c-Myc Monoclonal Antibody Recognizing the DNA-Binding Domain
- Intensified consolidation therapy with dose-escalated doxorubicin did not improve the prognosis of adults with acute lymphoblastic leukemia : the JALSG-ALL97 study
- Expanded distribution of the T315I mutation among hematopoietic stem cells and progenitors in a chronic myeloid leukemia patient during imatinib treatment
- Selective KIT inhibitor KI-328 and HSP90 inhibitor show different potency against the type of KIT mutations recurrently identified in acute myeloid leukemia
- Trough plasma concentration of imatinib reflects BCR-ABL kinase inhibitory activity and clinical response in chronic-phase chronic myeloid leukemia : A report from the BINGO study
- Clinical efficacy and safety of biapenem for febrile neutropenia in patients with underlying hematopoietic diseases : a multi-institutional study
- Virus-Associated Hemophagocytic Syndrome Caused by Pandemic Swine-Origin Influenza A (H1N1) in a Patient After Unrelated Bone Marrow Transplantation
- Mismatched human leukocyte antigen class II-restricted CD8^+ cytotoxic T cells may mediate selective graft-versus-leukemia effects following allogeneic hematopoietic cell transplantation
- Phase I trial of gemtuzumab ozogamicin in intensive combination chemotherapy for relapsed or refractory adult acute myeloid leukemia (AML) : Japan Adult Leukemia Study Group (JALSG)-AML206 study
- Analysis of bacteremia/fungemia and pneumonia accompanying acute myelogenous leukemia from 1987 to 2001 in the Japan Adult Leukemia Study Group
- A novel insertion mutation of K294RGG within BCR-ABL kinase domain confers imatinib resistance : sequential analysis of the clonal evolution in a patient with chronic myeloid leukemia in blast crisis
- Romiplostim for the treatment of chronic immune thrombocytopenia in adult Japanese patients : a double-blind, randomized Phase III clinical trial
- Efficacy and safety of nilotinib in Japanese patients with imatinib-resistant or -intolerant Ph+ CML or relapsed/refractory Ph+ ALL : a 36-month analysis of a phase I and II study
- Diagnosis of Intestinal Graft-versus-Host Disease and Thrombotic Microangiopathy after Allogeneic Stem Cell Transplantation
- Dexamethasone palmitate successfully attenuates hemophagocytic syndrome after allogeneic stem cell transplantation : macrophage-targeted steroid therapy
- Mutation of ARHGAP9 in patients with coronary spastic angina
- An open-label extension study evaluating the safety and efficacy of romiplostim for up to 3.5 years in thrombocytopenic Japanese patients with immune thrombocytopenic purpura (ITP)
- Randomized comparison of fixed-schedule versus response-oriented individualized induction therapy and use of ubenimex during and after consolidation therapy for elderly patients with acute myeloid leukemia : the JALSG GML200 Study
- Efficacy and safety of human adipose tissue-derived mesenchymal stem cells for supporting hematopoiesis
- Guest editorial : Introducing progress in hematology in this issue