A phase II, open-label, sequential-cohort, dose-escalation study of romiplostim in Japanese patients with chronic immune thrombocytopenic purpura

スポンサーリンク

概要

• 論文の詳細を見る
• 2009-09-15

著者

• MORI Shinichiro

  Hematopoietic Stem Cell Transplantation Unit, National Cancer Center Hospital

• Kishimoto Yuji

  Kansai Medical University Takii Hospital

• OHTSU Tomoko

  Amgen Limited

• ANDO Kiyoshi

  Tokai University

• MIYAMURA Koichi

  Japanese Red Cross Nagoya First Hospital

• Kurata Yoshiyuki

  Osaka University Hospital

• SHIRASUGI Yukari

  Tokai University Hospital

• HASHINO Satoshi

  Hokkaido University Hospital

• NAGASAWA Toshiro

  Tsukuba University Hospital

• IWATO Koji

  Hiroshima Red Cross Hospital and Atomic-Bomb Survivors Hospital

• BERGER Dietmar

  Amgen Inc., One Amgen Center Drive

• Berger Dietmar

  Amgen Inc. One Amgen Center Drive

• Kishimoto Yuji

  Kansai Medical Univ. Moriguchi Jpn

• Ando Kiyoshi

  Tokai University Hospital

• Kanamaru Akihisa

  Division Of Hematology Nephrology And Rheumatology Department Of Internal Medicine Kinki University

• Miyazawa Keisuke

  Department Of Hematology Tokyo Medical University

• Ohtsu Tomoko

  Amgen Kk

• Kikuchi Ako

  Tokai University

• Ando Kiyoshi

  Tokai Univ. Hospital Isehara Jpn

• Kurata Yoshiyuki

  Osaka Univ. Hospital Suita Jpn

• Hashino Satoshi

  Department Of Gastroenterology And Hematology Hokkaido University Hospital

• Miyazaki Koji

  Department Of Hematology Kitasato University Hospital

関連論文

• Allogeneic stem cell transplantation versus chemotherapy as post-remission therapy for intermediate or poor risk adult acute myeloid leukemia : results of the JALSG AML97 study
• Comparative analysis of remission induction therapy for high-risk MDS and AML progressed from MDS in the MDS200 study of Japan Adult Leukemia Study Group
• Interlaboratory Comparison of Quantitative RT-PCR Based Detection for Minimal Residual Disease in Leukemias : A Standardization Approach in Japan
• Successful treatment of minimal residual disease-positive Philadelphia chromosome-positive acute lymphoblastic leukemia with imatinib followed by reduced-intensity unrelated cord blood transplantation after allogeneic peripheral blood stein cell transplan
• Prospective trial of high-dose chemotherapy followed by infusions of peripheral blood stem cells and dose-escalated donor lymphocytes for relapsed leukemia after allogeneic stem cell transplantation
• Phase I and II pharmacokinetic and pharmacodynamic study of the proteasome inhibitor bortezomib in Japanese patients with relapsed or refractory multiple myeloma
• Enhanced expression of the EVI1 gene in NUP98/HOXA-expressing leukemia cells
• Role of the RUNX1-EVI1 fusion gene in leukemogenesis
• Outcome of allogeneic bone marrow transplantation from unrelated donors for adult Philadelphia chromosome-negative acute lymphocytic leukemia in first complete-remission
• Phase 1 trial of denosumab safety, pharmacokinetics, and pharmacodynamics in Japanese women with breast cancer-related bone metastases
• Phase I Study of Intravenous PSC-833 and Doxorubicin: Reversal of Multidrug Resistance
• A Phase I/II study of nilotinib in Japanese patients with imatinib-resistant or -intolerant Ph+ CML or relapsed/refractory Ph+ ALL
• Dose Modification of Imatinib by Monitoring the Level of BCR-ABL Transcript in Chronic Myelogenous Leukemia
• Imatinib Mesylate in Conjunction with Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Philadelphia Chromosome Positive Leukemias : Report of 4 Cases
• Detection of Clone-Specific Immunoglobulin Heavy Chain Genes in the Bone Marrow of B-cell-Lineage Lymphoma after Treatment
• High Expression of YB-1 Gene in Erythroid Cells in Patients with Refractory Anemia
• Phase 1/2 clinical study of dasatinib in Japanese patients with chronic myeloid leukemia or Philadelphia chromosome-positive acute lymphoblastic leukemia
• Phase I/II study of humanized anti-CD33 antibody conjugated with calicheamicin, gemtuzumab ozogamicin, in relapsed or refractory acute myeloid leukemia : final results of Japanese multicenter cooperative study
• Hematopoietic stem cell transplantation for acute promyelocytic leukemia in second or third complete remission : a retrospective analysis in the Nagoya Blood and Marrow Transplantation Group
• Comparison of leukopenia between cytarabine and behenoyl cytarabine in JALSG AML-89 consolidation therapy
• No beneficial effect from addition of etoposide to daunorubicin,cytarabine,and 6-mercaptopurine in individualized induction therapy of adult acute myeloid leukemia:the JALSG-AML92 study
• Phase II study of a salvage regimen using cyclophosphamide, high-dose cytarabine, dexamethasone, etoposide, and rituximab in patients with relapsed or refractory B-cell non-Hodgkin's lymphoma
• A phase II, open-label, sequential-cohort, dose-escalation study of romiplostim in Japanese patients with chronic immune thrombocytopenic purpura
• Toxicity and efficacy of ifosfamide, carboplatin and etoposide (modified ICE) as a salvage chemotherapy in Japanese patients with relapsed or refractory aggressive non-Hodgkin's lymphoma
• Recurrent Breast Cancer Treated Successfully with Mitomycin-C and Vinblastine after Failure of Both Doxorubicin-containing Regimen and Paclitaxel : A Case Report
• A Limited Sampling Model for Estimating Pharmacokinetics of CPT-11 and Its Metabolite SN-38
• Pharmacological Correlation between Total Drug Concentration and Lactones of CPT-11 and SN-38 in Patients Treated with CPT-11
• Graft-versus-tumor effect after reduced-intensity allogeneic hematopoietic stem cell transplantation in a patient with advanced colon cancer
• Prognostic Significance of FLT3 Internal Tandem Duplication and NPM1 Mutations in Acute Myeloid Leukemia in an Unselected Patient Population
• A Randomized Controlled Trial Investigating the Survival Benefit of Dose-Intensified Multidrug Combination Chemotherapy (LSG9) for Intermediate- or High-Grade Non-Hodgkin's Lymphoma : Japan Clinical Oncology Group Study 9002
• Multicenter Prospective Study of Interferon α versus Allogeneic Stem Cell Transplantation for Patients with New Diagnoses of Chronic Myelogenous Leukemia
• Combination Chemotherapy With Risk Factor-Adjusted Dose Attenuation for High-Risk Myelodysplastic Syndrome and Resulting Leukemia in the Multicenter Study of the Japan Adult Leukemia Study Group (JALSG): Results of an Interim Analysis
• Re-Treatment of Relapsed Indolent B-Cell Lymphoma With Rituximab
• Fludarabine- and Cyclophosphamide-Based Nonmyelobalative Conditioning Regimen for Transplantation of Chronic Granulomatous Disease : Possible Correlation with Prolonged Pure Red Cell Aplasia
• Nucleotide Alteration of Retinoblastoma Protein-Interacting Zinc Finger Gene, RIZ, in Human Leukemia
• Clinical features of adult acute leukemia with 11q23 abnormalities in Japan : a co-operative multicenter study
• Long-term Follow-up of 14 Patients with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia following Autologous Bone Marrow Transplantation in First Complete Remission
• Mechanisms of retinoid resistance in a myeloid cell line, YM711,transfected with PML/RARα cDNA : possible involvement of redox potential
• A safety, pharmacokinetic and pharmacodynamic investigation of deferasirox (Exjade^【○!R】, ICL670) in patients with transfusion-dependent anemias and iron-overload : a Phase I study in Japan
• Changes in Microbial Flora in Neutropenic Patients With Hematological Disorders After the Hanshin-Awaji Earthquake
• Myelodysplastic syndrome with B cell clonality in a patient five years after renal transplantation
• Recombinant human erythropoietin for late-onset anemia after allogeneic bone marrow transplantation
• Correlation between immunological abnormalities and prognosis in myelodysplastic syndrome patients
• Detection of donor-type alveolar macrophages in transplantation with highly purified CD34^+ bone marrow cells
• Myelodysplastic changes in three cases within 100 days after allogeneic bone marrow transplantation
• Thrombotic microangiopathy after treatment with bortezomib and dexamethasone in a patient with multiple myeloma
• Administration of micafungin as prophylactic antifungal therapy in patients undergoing allogeneic stem cell transplantation
• Acute-Onset Pancytopenia in a Postpartum Lactating Woman
• Donor-Type Myelodysplastic Syndrome with t(2;3) and Monosomy 7 after Allogeneic Peripheral Blood Stem Cell Transplantation and Liver Transplantation in a Patient with Severe-Type Aplastic Anemia
• Successful Nonmyeloablative Bone Marrow Transplantation for Leukocyte Adhesion Deficiency Type I from an Unrelated Donor
• Significance of Decreased Plasma D-Dimer Levels following Lipopolysaccharide-Induced Disseminated Intravascular Coagulation in Rats
• Recombinant adeno-associated virus-mediated gene transfer into human leukemia cell lines
• Decreased risk of acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation in patients with the 5,10-methylenetetrahydrofolate reductase 677TT genotype
• Serologically HLA-DR-Mismatched Unrelated Donors Might Provide a Valuable Alternative in Allogeneic Transplantation : Experience from a Single Japanese Institution
• Stable Engraftment after a Conditioning Regimen with Fludarabine and Melphalan for Bone Marrow Transplantation from an Unrelated Donor
• Severe Hypercholesterolemia Associated with Decreased Hepatic Triglyceride Lipase Activity and Pseudohyponatremia in Patients after Allogeneic Stem Cell Transplantation
• What is the most informative pharmacodynamic model for paclitaxel (T)? : a 3 hour-infusion vs. 24-hour infusion.
• Efficacy and safety of Micafungin in Febrile NeutropenicPatients Treated for Hematological Malignancies
• Aleukemic leukemia cutis in a patient with Philadelphia chromosome-positive biphenotypic leukemia.
• CD137-guided isolation and expansion of antigen-specific CD8 cells for potential use in adoptive immunotherapy
• Extramedullary Blast Crisis Derived from 2 Different Clones in the Central Nervous System and Neck during Complete Cytogenetic Remission of Chronic Myelogenous Leukemia Treated with Imatinib Mesylate
• Follicular Lymphoma in Osaka, Japan : Histological Features and Chronological Change
• A Case of Hypoplastic Chronic Myelogenous Leukemia Initiating With Pancytopenia
• Ex Vivo Expansion of Human Cord Blood Stem Cells and Its Application to Gene Therapy
• A simple and efficient purification of transduced cells by using green fluorescent protein gene as a selection marker
• Leukemia-related transcription factor TEL/ETV6 expands erythroid precursors and stimulates hemoglobin synthesis
• Possible involvement of the TGF-β1 signal in the development of peritoneal sclerosis as one of the major complications in continuous ambulatory peritoneal dialysis
• Serum KL-6 Levels in Patients With Pulmonary Complications After Allogeneic Bone Marrow Transplantation
• Ikk-i, a novel Lipopolysaccharide-inducible kinase that is realted to lκB Kinases
• Phase II study of oral fludarabine in combination with rituximab for relapsed indolent B-cell non-Hodgkin lymphoma
• Eosinophilic Colitis in a Patient with Acute Myeloid Leukemia after Allogeneic Bone Marrow Transplantation
• Histone deacetylase inhibitors trichostatin A and valproic acid circumvent apoptosis in human leukemic cells expressing the RUNX1 chimera
• Low-Level Expression of ETV6/TEL in Patients with Myelodysplastic Syndrome
• TEL/ETV6 Binds to Corepressor KAP1 via the HLH Domain
• Runx1/AML1 in Normal and Abnormal Hematopoiesis
• Human CD34^- Hematopoietic Stem Cells: Basic Features and Clinical Relevance
• Phase I study of the oral mammalian target of rapamycin inhibitor everolimus (RAD001) in Japanese patients with relapsed or refractory non-Hodgkin lymphoma
• Phase II study of ABVd therapy for newly diagnosed clinical stage II-IV Hodgkin lymphoma : Japan Clinical Oncology Group study (JCOG 9305)
• Trough plasma concentration of imatinib reflects BCR-ABL kinase inhibitory activity and clinical response in chronic-phase chronic myeloid leukemia : A report from the BINGO study
• Multicenter phase II study of bendamustine for relapsed or refractory indolent B-cell non-Hodgkin lymphoma and mantle cell lymphoma
• Phase I and pharmacokinetic study of bendamustine hydrochloride in relapsed or refractory indolent B-cell non-Hodgkin lymphoma and mantle cell lymphoma
• Clinical efficacy and safety of biapenem for febrile neutropenia in patients with underlying hematopoietic diseases : a multi-institutional study
• Chromosomal abnormalities and oncogenes
• Mismatched human leukocyte antigen class II-restricted CD8^+ cytotoxic T cells may mediate selective graft-versus-leukemia effects following allogeneic hematopoietic cell transplantation
• Safety and efficacy of the terminal complement inhibitor eculizumab in Japanese patients with paroxysmal nocturnal hemoglobinuria : the AEGIS Clinical Trial
• Lack of non-hematological cross intolerance of dasatinib to imatinib in imatinib-intolerant patients with Philadelphia chromosome positive chronic myeloid leukemia or acute lymphatic leukemia : a retrospective safety analysis
• Romiplostim for the treatment of chronic immune thrombocytopenia in adult Japanese patients : a double-blind, randomized Phase III clinical trial
• Feasibility and pharmacokinetic study of bendamustine hydrochloride in combination with rituximab in relapsed or refractory aggressive B cell non-Hodgkin's lymphoma
• Phase I and II study of azacitidine in Japanese patients with myelodysplastic syndromes
• Efficacy and safety of nilotinib in Japanese patients with imatinib-resistant or -intolerant Ph+ CML or relapsed/refractory Ph+ ALL : a 36-month analysis of a phase I and II study
• Diagnosis of Intestinal Graft-versus-Host Disease and Thrombotic Microangiopathy after Allogeneic Stem Cell Transplantation
• Dexamethasone palmitate successfully attenuates hemophagocytic syndrome after allogeneic stem cell transplantation : macrophage-targeted steroid therapy
• Outpatient peripheral blood stem cell collection in Japan
• An open-label extension study evaluating the safety and efficacy of romiplostim for up to 3.5 years in thrombocytopenic Japanese patients with immune thrombocytopenic purpura (ITP)
• Hepatosplenic Gamma-delta T-cell Lymphoma Associated with Epstein-Barr Virus

もっと見る 閉じる

スポンサーリンク