Effects of long-term ingestion of difructose anhydride III (DFA III) on intestinal bacteria and bile acid metabolism in humans
スポンサーリンク
概要
- 論文の詳細を見る
Changes in the intestinal microbiota of 10 human subjects with long-term ingestion of 3 g/d difructose anhydride III (DFA III; 4 persons, 2 months; 3 persons, 6 months; and 3 persons, 12 months) were examined by denaturing gradient gel electrophoresis (DGGE). According to the answers to questionnaires, the subjects were divided into two groups (constipated and normal). The DGGE profile was different for every individual and each subject had unique profiles of intestinal microbiota. In the DGGE profiles of constipated subjects, the intensities of bands related to Bacteroides spp. increased. Moreover, the DFA III-assimilating bacteria, Ruminococcus sp. were isolated from subjects who ingested DFA III for 12 months. These strains showed 95% similarity of their 16S rDNA sequences with that of Ruminococcus obeum ATCC 29174T (X85101) and produced large amounts of acetic acid. DFA III ingestion for 2 months tended to increase total organic acids in feces, and tended to decrease fecal pH and the secondary bile acid (SBA) ratio in total bile acids. The SBA ratio in total bile acids corresponded to fecal pH. The production of SBA was decreased by low pH in vitro. These results indicated that DFA III ingestion in humans tended to lower intestinal pH, inhibited bile acid 7α-dehydroxylation activities and also tended to decrease the SBA ratios in total bile acids. Moreover, as another cause for the decrease in the SBA ratio in total bile acids, it was suggested that the number of bile acid 7α-dehydroxylating bacteria were decreased by DFA III ingestion
- 社団法人日本生物工学会の論文
- 2006-02-25
著者
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Sone Teruo
Laboratory Of Applied Microbiology Graduate School Of Agriculture Hokkaido University
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Sone Teruo
北海道大学 農学研究院応用生命科学部門
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Sone Teruo
Laboratory Of Applied Microbiology Research Group Of Molecular Bioscience Division Of Applied Biosci
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Sone Teruo
Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University
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ASANO Kozo
Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University
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Minamida Kimiko
Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University
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Abe Ayumi
Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University
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Tomita Fusao
Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University
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Minamida Kimiko
Northern Advancement Center for Science and Technology
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Asakawa Chikako
Northern Advancement Center for Science and Technology
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Sujaya I
Northern Advancement Center for Science and Technology
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Kaneko Maki
Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University
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Hara Hiroshi
Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University
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冨田 房男
北海道大学農学部
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冨田 房男
Hokkaido Study Center The University Of Air
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Sujaya Inengah
Northern Advancement Center For Science And Technology
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Abe Ayumi
Department Of Bioscience And Chemistry Graduate School Of Agriculture Hokkaido University
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Sone T
Laboratory Of Applied Microbiology Graduate School Of Agriculture Hokkaido University
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Sone Teruo
Laboratory Of Applied Microbiology Department Of Bioscience And Chemistry Faculty Of Agriculture Hok
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Sujaya I-nengah
Department Of Bioscience And Chemistry Graduate School Of Agriculture Hokkaido University
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Asano Kozo
Lab. Of Applied Microbiology Graduate School Of Agriculture Hokkaido Univ. Kita-9 Nishi-9 Sapporo 06
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Asano K
Foods And Liquors Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Asano Kozo
北海道大学農学部応用生命科学専攻
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Asano Kozo
Division Of Applied Bioscience Graduate School Of Agriculture Hokkaido University
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Kaneko Maki
Division Of Applied Bioscience Graduate School Of Agriculture Hokkaido University
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Tomita Fusao
Hokkaido University:hokkaido Study Center University Of The Air
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Tomita Fusao
Laboratory Of Applied Microbiology
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Tomita Fusao
Department Of Agricultural Chemistry Faculty Of Agriculture Hokkaido University
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Tomita Fusao
Department Of Agricultural Biochemistry Faculty Of Agriculture Hokkaido University
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Tomita Fusao
Laboratory Of Applied Microbiology Department Of Bioscience And Chemistry Faculty Of Agriculture Hok
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Shiomi Takuya
Fancl Res. Inst. Fancl Corp.
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Hara H
Lab. Of Nutritional Biochemistry Div. Of Applied Bioscience Graduate School Of Agriculture Hokkaido
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Tomita Fusao
Division Of Applied Bioscience Graduate School Of Agriculture Hokkaido University
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Minamida Kimiko
Division Of Applied Bioscience Graduate School Of Agriculture Hokkaido University
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Asakawa Chikako
Northern Advancement Center For Science & Technology
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Hara Hiroshi
Toxicology Laboratory Chugai Pharmaceutical Co. Ltd.
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Abe Ayumi
Research Faculty Of Agriculture Hokkaido University
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Hara Hiroshi
Division Of Applied Bioscience Graduate School Of Agriculture Hokkaido University
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Sone Teruo
Laboratory of Applied Microbiology, Graduate Faculty of Agriculture, Hokkaido University
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Abe Ayumi
Laboratory of Applied Microbiology, Graduate Faculty of Agriculture, Hokkaido University
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