2α, 3α-EPITHIO-5α-ANDROSTAN-17β-YL 1-METHOXY CYCLOPENTYL ETHER (10364-S), A NEW ORALLY ACTIVE ANABOLIC-ANDROGENIC STEROID
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概要
- 論文の詳細を見る
2α, 3α-Epithio-5α-androstan-17β-yl l-methoxycyclopentyl ether (10364-S) was found to possess marked myotropic and androgenic activities by oral route in the rat, and its potency and myotropic-androgenic ratio were estimated to be almost equivalent to those of fluoxymesterone. It was further demonstrated that the oral administration of 10364-S, 20 mg/kg a day for 3 weeks, had hardly no effect on liver function of rabbits tested by BSP retention, plasma GOT and GPT activities, and plasma cholesterol levels, whereas treatment with methyltestosterone, oxymetholone or fluoxymesterone, at the same dosage, caused abnormal BSP retention and plasma GOT activity. It is thus concluded, that 10364-S when given orally is an active anabolic agent with a therapeutic potency equivalent to fluoxymesterone yet in clinical administration is less likely to cause hepatic disturbance.
- 社団法人 日本薬理学会の論文
著者
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NOMURA Yasuharu
Shionogi Research Laboratories
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Kakushi Hisato
Shionogi Research Laboratories Shionogi & Co. Ltd.
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KADOWAKI MASUMI
Shionogi Research Laboratories
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MIYATA KENJI
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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MIYAKE TAMOTSU
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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Uchida Kiyohisa
Shionogi Aburahi Laboratories
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HANAFUSA Tomoyuki
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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MURANAKA Ri-ichi
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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MIYAKE TAMOTSU
Shionogi Research Laboratory
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HANAFUSA Tomoyuki
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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MURANAKA Ri-ichi
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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KAKUSHI HISATO
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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NOMURA YASUHARU
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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KADOWAKI Masumi
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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