Acute Effects of Ovarian Steroids upon Follicular Growth in the Cycling Rat
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概要
- 論文の詳細を見る
Acute effects of ovarian steroids on the enlargement of a given set of follicles greater than 750μ in diameter were evaluated in the cycling rat under chlorpromazineblockade for ovulation by direct analysis of isolated follicles from fresh ovaries. A steady enlargement of newly generated follicles destined to ovulate was obviously delineated throughout the estrous cycle by newly devised assay. When ovulation was blocked by chlorpromazine hydrochloride (5mg/kg) given shortly before ovulatory release of gonadotropins, a successive linear increase in the follicular volume was kept at least by the expected day of estrus. Under these conditions, progesterone given at diestrus 2 caused a pronounced retardation of following follicular growth, the effective doses of which were almost comparable to those neccessary to prevent ovulation. Varying doses of estradiol ranging from 0.1 to 100μg given at diestrus 2 or daily dose of 10μg given at diestrus 2 and proestrus failed to cause any significant changes in average number of follicles and total follicular volume at the expected day of estrus. When given at estrus, however, it markedly suppressed the successive follicular growth. These results indicate that the exogenous estradiol itself is not able to alter the process of final course of follicular maturation when corpora lutea once degenerated, and that the suppression of follicular growth by estradiol given at estrus is probably due to the action of progesterone, the increased secretion of which is prolonged by the luteotropic action of the extrinsic estrogen.
- 社団法人 日本内分泌学会の論文
著者
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MIYAKE TAMOTSU
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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HORI TAKASHI
Shionogi Research Laboratory, Shionogi and Co., Ltd.
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KATO GORO
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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HORI TAKASHI
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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MIYAKE TAMOTSU
Shionogi Research Laboratory
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KATO GORO
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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