Vitamin K-Reversible Hypoprothrombinemia in Rats I. Sex Differences in the Development of Hypoprothrombinemia and the Effects of Beta-Lactam Antibiotics
スポンサーリンク
概要
- 論文の詳細を見る
Male and female rats were fed an ordinary diet which contained about 500 ng vitamin K/g or a vitamin K-deficient diet containing less than 5 ng vitamin K/g. Hypoprothrombinemic changes such as prolongation of the prothrombin time (PT) and activated partial thromboplastin time (APTT) were detected in male rats within 4-6 days after feeding of the vitamin K deficient diet. Blood clotting factor VII and descarboxy prothrombin (PIVKA) levels changed rapidly, with maximum alteration at 2-4 days. Similar changes in factor VII and PIVKA levels were observed in female rats, but they appeared only after feeding of the K deficient diet for a long period. PT and APTT in female rats showed slight or no alteration even after 10 day feeding of the K-deficient diet. These results indicate that male rats are more susceptible to vitamin K deficiency than female rats. Administration of latamoxef led to a dose-dependent development of hypoprothrombinemia in vitamin K-deficient female rats. The hypoprothrombinemia in vitamin K-deficient female rats was caused by beta-lactam antibiotics with N-methyltetrazolethiol, thiadiazolethiol and methyl-thiadiazolethiol as the 3-position substituent of the cephem nucleus.
著者
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Satoh Seiji
Kanzakigawa Laboratory Shionogi Research Laboratories
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Matsuura Minoru
Kanzakigawa Laboratory Shionogi Research Laboratories
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Matsubara Takashi
Shionogi Research Laboratories
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Uchida Kiyohisa
Shionogi Aburahi Laboratories
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YOSHIZAKI Toshio
Kanzakigawa Laboratory, Shionogi Research Laboratories
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Kobayashi Fumihiko
Kanzakigawa Laboratory Shionogi Research Laboratories
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TAKANO Kyoji
Kanzakigawa Laboratory, Shionogi Research Laboratories
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HARAUCHI Toshio
Kanzakigawa Laboratory, Shionogi Research Laboratories, Shionogi & Co., Ltd.
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HARAUCHI Toshio
Kanzakigawa Laboratory, Shionogi Research Laboratories
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