Hepatic 7-alkoxycoumarin O-dealkylase in mice: Induction by .BETA.-naphthoflavone of hepatic enzyme activity.

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Hepatic 7-alkoxycoumarin O-dealkylation activities in control and β-naphthoflavone-pretreated mice were determined. The O-demethylation and O-deethylation activities of 7-alkoxycoumarin in control mice were almost the same values, while the O-depropylation activity was lower than those of the other reactions. The O-dealkylase activity varied markedly among the 18 strains of mice surveyed, and strain-dependent differences in the cytochrome P-450 content were also detected among the strains. β-Naphthoflavone induced O-dealkylation activity, especially O-deethylation and O-depropylation activities, only in ddY, DS and its substrains (A2-3, A3-1, C1-2 and Nh/+), C3H/He and C57BL/6J strains, but not in DBA/2, BALB/c and KYF/2 strains. The former strains of mice are thus classified as "responsive strains" to β-naphthoflavone and the latter as "non-responsive strains". The O-dealkylase activity in other strains of mice were not clear in responsiveness to β-naphthoflavone. The hepatic cytochrome P-450 content in responsive strains also increased upon pretreatment of the animals with β-haphthoflavone. The results indicate marked strain differences in basal and β-naphthoflavone-induced activity of hepatic 7-alkoxycoumarin O-dealkylase in mice.
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