Effects of beta-lactam antibiotics on the acetaldehyde-metabolizing system in germ-free rats.
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概要
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Effects of several beta-lactam antibiotics on the acetaldehyde-metabolizing system were studied using germ-free rats. Administration of cefamandole (CMD) to the rats caused a decrease in liver mitochondrial low K<SUB>m</SUB> aldehyde dehydrogenase activity and an increase in blood acetaldehyde level during ethanol metabolism, similar to the case in conventional rats. Oral administration of CMD produced a pronounced increase in blood acetaldehyde level compared to the subcutaneous administration of the antibiotic. When the animals were given various beta-lactam antibiotics subcutaneously, only the antibiotics having an N-methyltetrazolylthiomethyl group at the 3-position of the cephalosporin nucleus exhibited the disulfiram-like effects on the acetaldehyde-metabolizing system. The results indicate that intestinal bacteria do no participate in the development of the disulfiram-like reaction of several beta-lactam antibiotics.
- 公益社団法人 日本薬理学会の論文
著者
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OTSUBO Shigemi
Shionogi Research Laboratories, Shionogi & Co., Ltd.
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OGAWA Ayako
Shionogi Research Laboratories, Shionogi & Co. Ltd.
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Matsubara Takashi
Shionogi Research Laboratories
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OGAWA Ayako
Shionogi Research Laboratories, Shionogi & Co. Ltd.
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NAKAO Hiroyuki
Aburahi Laboratories, Shionogi Research Laboratories, Shionogi & Co. Ltd.
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