Effects of Serum Albumin and Liver Cytosol on CYP2C9-and CYP3A4-mediated Drug Metabolism

スポンサーリンク

概要

• 論文の詳細を見る
• 2003-02-20

著者

• YAMAZOE Yasushi

  Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, To

• SUGIYAMA Yuichi

  Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, The University of Tokyo

• Yamazoe Yasushi

  Division Of Drug Metabolism And Molecular Toxicology Graduate School Of Pharmaceutical Sciences Toho

• Baba Takahiko

  Shionogi & Co. Ltd. Developmental Research Laboratories

• ITO Kiyomi

  School of Pharmaceutical Sciences, Kitasato University

• YAMAGUCHI Yoshitaka

  Shionogi Research Laboratory

• Ito Kiyomi

  School Of Pharmaceutical Sciences Kitasato University

• Yamazoe Yasushi

  Division Of Drug Metabolism & Molecular Toxicology Graduate School Of Pharmaceutical Sciences To

• Yamaguchi Yoshitaka

  Shionogi & Co. Ltd. Developmental Research Laboratories

• OHNO Yasuo

  Healthcare Research Laboratories, Consumer Healthcare Company, Takeda Chemical Industries, Ltd.

• Touchi Akira

  Shionogi & Co. Ltd. Developmental Research Laboratories

• Ito K

  School Of Pharmaceutical Sciences Kitasato University

• Ohno Y

  Health Sciences Division Of Pharmacology Biological Safety Research Center National Institute Of Hea

• Sugiyama Yuichi

  Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences University Of Tokyu

• Sugiyama Yuichi

  Department Of Applied Biological Science Faculty Of Science And Technology Science University Of Tok

• OHNO Yasuo

  Health Sciences, Division of Pharmacology, Biological Safety Research Center, National Institute of Health Sciences

関連論文

• ヒトP450分子種の HepG2 細胞における複数同時発現 : 組換えアデノウイルスを用いたP450再構成系
• ヒト薬物動態関連遺伝子の発現に対するHNF4αの寄与をsiRNA発現アデノウイルスを用いて解析する
• Novel mutations identified in the human multidrug resistance-associated protein 2 (MRP2/ABCC2) gene in a Japanese patient with Dubin-Johnson syndrome
• Tumor Necrosis Factor-Alpha–Nuclear Factor-Kappa B-Signaling Enhances St2b2 Expression during 12-O-Tetradecanoylphorbol-13-acetate-Induced Epidermal Hyperplasia
• Molecular Cloning and Characterization of Rat ST1B1 and Human ST1B2 cDNAs, Encoding Thyroid Hormone Sulfotransferases
• Bile Acid-Induced Elevated Oxidative Stress in the Absence of Farnesoid X Receptor(Biochemistry)
• Hydroxysteroid sulfotransferase (SULT2A) の発現はFXRにより抑制的に調節される
• Bile acid-induced liver toxicity and nuclear receptor FXR (LIVER/DIGESTIVE SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
• Mechanism of 7,12-Dimethylbenz[α]anthracene-Induced Immunotoxicity: Role of Metabolic Activation at the Target Organ
• Construction of Several Human-derived Stable Cell Lines Displaying Distinct Profiles of CYP3A4 Induction
• Differences in Transactivation between Rat CYP3A1 and Human CYP3A4 Genes by Human Pregnane X Receptor
• A Hydroxysteroid Sulfotransferase, St2b2, Is a Skin Cholesterol Sulfotransferase in Mice
• Adenovirus Vector-Mediated Reporter System for In Vivo Analyses of Human CYP3A4 Gene Activation
• Alteration of Hepatic Sulfation by Endotoxin
• Enzymatic Characterization of Human Cytosolic Sulfotransferases : Identification of ST1B2 as a Thyroid Hormone Sulfotransferase
• Bacterial Expression and Functional Characterization of a Rat Thyroid Hormone Sulfotransferase, ST1B1
• Molecular Cloning, Expression, and Enzymatic Characterization of Rabbit Hydroxysteroid Sulfotransferase AST-RB2 (ST2A8)^1
• RNA干渉法を用いたヒト肝チトクロムP450遺伝子の転写活性化に及ぼすPXRの寄与の評価
• Selective Suppressions of Human CYP3A Forms, CYP3A5 and CYP3A7, by Troglitazone in HepG2 Cells
• Molecular Cloning and Expression of an Amine Sulfotransferase cDNA: A New Gene Family of Cytosolic Sulfotransferases in Mammals^1
• Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia
• QUANTITATIVE RELATIONSHIP BETWEEN IN VIVO BENZODIAZEPINE RECEPTOR OCCUPANCY AND CEREBRAL METABOLIC CHANGE IN THE MOUSE
• BINDING, INTERNALIZATION AND DEGRADATION OF ATRIAL NATRIURETIC PEPTIDE IN ISOLATED CHOROID PLEXUS
• THE TRANSPORT SYSTEM OF BENZYLPENICILLIN IN THE BLOOD-CEREBROSPINAL FLUID BARRIER
• THE EFFECT OF BASIC DRUGS ON THE HEPATIC TRANSPORT OF CARDIAC GLYCOSIDES IN RATS
• THE TRANSPORT SYSTEM OF CIMETIDINE FROM THE RAT CEREBROSPINAL FLUID : IN VIVO AND IN VITRO STUDIES
• INTERACTION OF OUABAIN AND ROSE BENGAL WITH RAT LIVER PLASMA MEMBRANES
• 22D-11-2 Modifying the pharmacokinetics of the anticancer drug CPT-11, and its active metabolite SN-38, aimed at reducing the biliary excretion of SN-38 and its gastrointestinal toxicity.
• Development of an In Vitro System Detecting Pro-embryotoxin
• Inhibitory Potential of Herbal Medicines on Human Cytochrome P450-Mediated Oxidation : Properties of Umbelliferous or Citrus Crude Drugs and Their Relative Prescriptions
• Inhibitory Effect of Natural Furanocoumarins on Human Microsomal Cytochrome P450 3A Activity
• Rivulobirin E and Rivulotririn C from Pleurospermum rivulorum
• Galactosyldiacylglycerol, a Mammalian DNA Polymerase α-Specific Inhibitor from a Sea Alga, Petalonia bingbamiae
• Quantitative Prediction of In Vivo Drug-drug Interactions from In Vitro Data : Effects of Active Transport of Inhibitors into the Liver
• 21C-04-3 Is It Possible to Quantitatively Predict In Vivo Drug Metabolizing Activity of Cytochrome P450 in Human Liver from In Vitro Metabolic Studies ?
• 2C-22 Quantitative prediction of in vivo metabolic activity in the liver from in vitro data based on the P450 isozyme involved.
• "S2-4 STRATEGIC PROPOSALS FOR AVOIDING TOXIC INTERACTIONS WITH DRUGS FOR CLINICAL USE DURING DEVELOPMENT AND AFTER MARKETING OF A NEW DRUG : PHARMACOKINETIC CONSIDERATION (Strategy how we can learn drug-drug interaction during the development
• POSSIBLE MECHANISMS FOR THE CHANGES IN MICROCLIMATE-pH IN THE RAT SMALL INTESTINE AND EFFECTS OF PHENOTHIAZINE DERIVATIVES IN VIVO
• Bilirubin Oxidase from Trachyderma tsunodae K-2593,a Multi-copper Enzyme
• Expression and Regulation of Breast Cancer Resistance Protein and Multidrug Resistance Associated Protein 2 in BALB/c Mice(Pharmacology)
• Metabolism of N, N-Dipropyl-2-[4-Methoxy-3-(2-Phenyl-Ethoxy)-Phenyl]-Ethyl-Amine-Monohydrochloride(NE-100), A Novel Sigma Ligand : Contribution of Cytochrome P450 Forms Involved in the Formation of Individual Metabolites in Human Liver and Small Intestine
• Effect of Genetic Polymorphism of OATP-C (SLCO1B1) on Lipid-Lowering Response to HMG-CoA Reductase Inhibitors
• Effect of Moisture on Impact Toughness of Sugar-Coated Tablets Manufactured by the Dusting Method
• Improvement of Impact Toughness of Sugar-Coated Tablets Manufactured by the Dusting Method
• Grapefruit Component Interacting with Rat and Human P450 CYP3A : Possible Involvement of Non-Flavonoid Components in Drug Interaction
• Pharmacokinetic interaction between pravastatin and olmesartan in relation to SLCO1B1 polymorphism
• Construction of the in vitro transporter experimental systems for prediction of the dexification of drugs in human liver : Utilization of human cryopreserved hepatocytes and double transfectants
• Evaluation of Methods for Prediciting Drug-drug Interactions by Monte Carlo Simulation
• Effects of Serum Albumin and Liver Cytosol on CYP2C9-and CYP3A4-mediated Drug Metabolism
• Lack of Contribution of P-Glycoprotein (P-gp) to Transport via the Mouse Blood-Cerebrospinal Fluid Barrier
• The role of breast cancer resistance protein, Bcrp in the transport of estrone-3-sulfate and dehydroepiandrosterone sulfate across the blood-brain barrier
• Metabolic activation of chemicals in various organs as key events for tissue specific toxicities(SYMPOSIUM 1 : MECHANISMS OF HEPATOTOXIC EFFECTS)
• Impact of Genetic Polymorphisms of Transporters on the Pharmacokinetic, Pharmacodynamic and Toxicological Properties of Anionic Drugs
• FUTURE PROSPECTS FOR TOXICOKINETICS : PREDICTION OF DRUG DISPOSITION AND ADVERSE EFFECTS IN HUMANS FROM IN VITRO MEASUREMENTS OF DRUG METABOLISM, TRANSPORT AND BINDING
• Analysis of citrulline in rat brain tissue after perfusion with haloperidol by liquid chromatography-mass spectrometry
• Analysis of citrulline in rat brain tissue after perfusion with haloperidol by liquid chromatography-mass spectrometry
• Determination of 1-methyl-1,2,3,4-tetrahydroisoquinoline in mouse brain after treatment with haloperidol by gas chromatography-selected ion monitoring
• CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN RATS: EVIDENCE FOR DIFFERENT SUSCEPTIBILITIES OF RAT LIVER LOBES
• ALTERATION OF HEPATIC P-450 MONOOXYGENASE SYSTEM FOLLOWING ADMINISTRATION OF CARBON TETRACHLORIDE (The 6th Meeting for the Study of Toxic Effect)
• Species and Sex Differences in the Inhibitory Action of the Corticosteroid Alclometasone Dipropionate on the Hepatic Drug-Metabolizing System
• Construction of a System that Simultaneously Evaluates CYP1A1 and CYP1A2 Induction in a Stable Human-derived Cell Line using a Dual Reporter Plasmid
• BIOTRANSFORMATION OF COUMARIN DERIVATIVES (2) OXIDATIVE METABOLISM OF 7-ALKOXYCOUMARIN BY MICROSOMAL ENZYMES AND A SIMPLE ASSAY PROCEDURE FOR 7-ALKOXYCOUMARIN O-DEALKYLASE
• AUTOINDUCTION OF 450191-S, A NEW SLEEP INDUCER OF 1H-1,2,4-TRIAZOLYL BENZOPHENONE DERIVATIVE, IN DOGS
• INDUCTION OF RAT LIVER MICROSOMAL DRUG-METABOLIZING ENZYMES BY A NEW SLEEP INDUCER 450191-S AND PLASMA LEVELS OF 450191-S-METABOLITES
• HEPATIC AMINOPYRINE N-DEMETHYLASE SYSTEM: FURTHER STUDIES OF ASSAY PROCEDURE
• HETEROGENEOUS DISTRIBUTION OF THE CYTOCHROME P-450 MONOOXYGENASE SYSTEM IN RAT LIVER LOBES
• Report 3 : FUTURE PROSPECTS FOR TOXICOKINETICS : ITS ABILITY TO PREDICT DRUG ADVERSE EVENTS IN HUMANS (TOXICOKINETICS)
• HEPATIC AMINOPYRINE N-DEMETHYLASE SYSTEM: EFFECT OF CYANIDE ON MICROSOMAL N-DEMETHYLASE ACTIVITY
• Association study of genetic polymorphisms of drug transporters, SLCO1B1, SLCO1B3 and ABCC2, in African-Americans, Hispanics and Caucasians and olmesartan exposure
• Hepatic 7-alkoxycoumarin O-dealkylase in mice: Induction by .BETA.-naphthoflavone of hepatic enzyme activity.
• Fibroblast Growth Factor 19 Treatment Ameliorates Disruption of Hepatic Lipid Metabolism in Farnesoid X Receptor (Fxr)-Null Mice
• In vitro effects of various heterocyclic thiol compounds and .BETA.-lactam antibiotics on vitamin K-dependent .GAMMA.-glutamylcarboxylation activity in liver microsomes.
• In vitro effect of beta-lactam antibiotics and N-methyl-tetrazolethiol on microsomal vitamin K epoxide reductase in rats.
• Effect of change of hepatic drug-metabolizing activity on plasma concentrations of major metabolites of the new sleep inducer 450191-S, a 1H-1,2,4-triazolyl benzophenone derivative.
• Effect of N-methyltetrazolethiol on liver microsomal gamma-glutamylcarboxylation. Modification of the in vitro action of N-methyltetrazolethiol.
• Adenovirus Vector-Mediated Reporter System for In Vivo Analyses of Human CYP3A4 Gene Activation.
• A Hydroxysteroid Sulfotransferase, St2b2, Is a Skin Cholesterol Sulfotransferase in Mice.
• Molecular Cloning and Characterization of Rat ST1B1 and Human ST1B2 cDNAs, Encoding Thyroid Hormone Sulfotransferases.

もっと見る 閉じる

スポンサーリンク