Grapefruit Component Interacting with Rat and Human P450 CYP3A : Possible Involvement of Non-Flavonoid Components in Drug Interaction
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概要
- 論文の詳細を見る
Active components in grapefruit juice, which modulate a cytochrome P450 (CYP3A) activity, were investigated. CYP3A-catalyzed 6β-hydroxylation of testosterone in livers of rat and human was inhibited by the addition of an ethyl acetate-extract of grapefruit juice. Several components of grapefruit juice, including naringin, naringenin, limonin and obacunone, also showed inhibitory effects in human liver microsomes. However, the amounts of these components in grapefruit juice are too low to account for the inhibition by the ethyl acetate-extracts. Analyses with HPLC indicate the existence of inhibitory components in the extract, which are distinct from these known compounds and are specific to grapefruit juice. These results suggest that hydrophobic components other than flavonoids, probably coumarin derivatives, are responsible for the inhibitory effect of grapefruit juice.
- 公益社団法人日本薬学会の論文
- 1997-05-15
著者
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OHTA Tomihisa
Division of Core Facility of Medical Research Institute, Kanazawa Medical University
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YAMAZOE Yasushi
Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, To
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Yamazoe Y
Tohoku Univ. Sendai Jpn
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Ohta Tomihisa
Division Of Pharmacognosy Faculty Of Pharmaceutical Sciences Tohoku University
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Yamazoe Yasushi
Division Of Drug Metabolism & Molecular Toxicology Graduate School Of Pharmaceutical Sciences To
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FUKUDA Katsuyuki
Division of Drug Metabolism and Molecular Toxicology, Faculty of Pharmaceutical Sciences, Tohoku Uni
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Fukuda Katsuyuki
Division Of Drug Metabolism And Molecular Toxicology Faculty Of Pharmaceutical Sciences Tohoku Unive
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Yamazoe Yasushi
Division Of Drug Metabolism And Molecular Toxicology Faculty Of Pharmaceutical Sciences Tohoku Unive
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