Inhibitory Effect of Natural Furanocoumarins on Human Microsomal Cytochrome P450 3A Activity
スポンサーリンク
概要
- 論文の詳細を見る
To investigate the possible drug interaction with herbal medicine, furanocoumarin derivatives isolated from several Umbelliferous crude drugs were examined for their inhibitory effects on a typical human drug metabolizing enzyme, cytochrome P450 3A(CYP3A).Most furanocoumarins tested at 0.1mM reduced microsomal testosterone 6β-hydroxylation as an index of CYP3A activity to less than 50% of the control.In particular, the dimer and trimer derivatives of furanocoumarins showed striking inhibition, whose potencies were similar to that of a typical CYP3A inhibitor, ketoconazole.Preincubation of dimer types of furanocoumarins increased suppression but not most of the monomer derivatives, suggesting that the inhibition on CYP3A activity was caused by at least plural mechanisms.These results raised the possibility that the furanocoumarin containing herbal medicines may alter pharmacokinetics of co-ingested drugs similar to the case with grapefruit juice.
- 社団法人 日本薬理学会の論文
- 2000-02-01
著者
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YAMAZOE Yasushi
Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, To
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Yamazoe Y
Division Of Drug Metabolism And Molecular Toxicology Graduate School Of Pharmaceutical Sciences Toho
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Yamazoe Yasushi
Department Of Pharmacology School Of Medicine Keio University:department Of Analytical Biochemistry
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Tokunaga Masashi
A・pharma Kindai Co. Ltd
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Baba K
Laboratory Of Pharmacognostical Sciences Osaka University Of Pharmaceutical Sciences
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Baba Kimiye
Osaka Univ. Pharmaceutical Sci. Osaka Jpn
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Baba K
Faculty Of Phamacognosy Osaka University Of Pharmaceutical Sciences
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Tokunaga Masashi
近畿大学 薬学部
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Yamazoe Yasushi
Division Of Drug Metabolism And Molecular Toxicology Graduate School Of Pharmaceutical Sciences Toho
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TANIGUCHI Masahiko
Osaka University of Pharmaceutical Sciences
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Baba Kenji
Third Department Of Medicine Aichi Medical School School Of Medicine
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GUO Lian-Qing
Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, To
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TANIGUCHI Masahiko
Division of Pharmacognosy, Osaka University of Pharmaceutical Sciences
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XIAO Yong-Qing
Division of Pharmacognosy, Osaka University of Pharmaceutical Sciences
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BABA Kimiye
Division of Pharmacognosy, Osaka University of Pharmaceutical Sciences
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OHTA Tomihisa
Faculty of Pharmaceutical Sciences, Kanazawa University
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Baba K
Division Of Pharmacognosy Osaka University Of Pharmaceutical Sciences
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Ohta Tomihisa
Faculty Of Pharmaceutical Sciences Kanazawa University
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Taniguchi Masahiko
Division Of Pharmacognosy Osaka University Of Pharmaceutical Sciences
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Taniguchi Masahiko
Division Of Material Chemistry Faculty Of Engineering Kyoto University
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Yamazoe Yasushi
Division Of Drug Metabolism & Molecular Toxicology Graduate School Of Pharmaceutical Sciences To
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Guo Lian-qing
Division Of Drug Metabolism And Molecular Toxicology Graduate School Of Pharmaceutical Sciences Toho
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Taniguchi M
Kyoto Res. Lab. Kyoto Jpn
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Xiao Yong-qing
Division Of Pharmacognosy Osaka University Of Pharmaceutical Sciences
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Yamazoe Yasushi
Division Of Drug Metabolism And Molecular Toxicology Graduate School Of Pharmaceutical Sciences Toho
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