<Originals>Interferon-γ modulate Ia antigen expression on thymic reticuloepithelial cells in New Zealand mice

概要

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The defect in syngeneic mixed lymphocyte reaction in New Zealand black (NZB) mice, an animal model of human autoimmune diseases, is primarily caused by T cell abnormality in the recognition of self (Ia) antigens. This T cell abnormality is possibly associated with the abnormal activation of T cell in the thymus due to the abnormal expression of Ia antigens on thymic reticuloepithelial cells (TRC) of NZB mice. To correct the T cell abnormality in recognition of Ia antigens, we evaluated the effects of Interferon-γ (IFN-γ) on the Ia antigen expression on TRC : IFN-γwas added to the culture of TRC, and changes in the positive rate and amount of Ia antigens on TRC were studied by flow cytofluorometry. Pretreatment value of the Ia antigens on TRC was lower in NZB mice than in normal mice. However, the addition of IFN-γincreased the value of Ia antigens on TRC in NZB mice to the level similar to that in normal mice. The degree of increase was greater in NZB mice than in normal mice, which suggests that sensitivity to IFN-γis enhanced in the former. These results suggest that the addition of IFN-γmay have corrected the abnormality of T cells during the differentiation process of T cells in the thymus by increasing the Ia antigens on TRC in NZB mice.
近畿大学の論文