Development of an In Vitro System Detecting Pro-embryotoxin
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概要
- 論文の詳細を見る
An in vitro system for detection of embryotoxins has been developed by using primary cultures of embryo fibroblasts. Various embryotoxins, including benzo[a]pyrene and thalidomide, have trivial cytotoxicity in embryo fibroblast systems, which is at least in part due to a lack of capacity for metabolic activation. Introduction of steps for microsomal pre-incubation and calcium-precipitation prior to chemical contact resulted in the clear appearance of embryotoxicity toward thalidomide and benzo[a]pyrene. This pre-incubation method will offer advantages for the detection of embryotoxins, which require maternal metabolic activation, and for understanding the mechanisms of their metabolic activations.
- 社団法人 日本薬理学会の論文
- 2002-07-01
著者
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YAMAZOE Yasushi
Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, To
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Yamazoe Y
Division Of Drug Metabolism And Molecular Toxicology Graduate School Of Pharmaceutical Sciences Toho
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Yamazoe Yasushi
Department Of Pharmacology School Of Medicine Keio University:department Of Analytical Biochemistry
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Miyata Masaaki
東北大学 薬学研究科薬物動態学
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Miyata Masaaki
Division Of Drug Metabolism And Molecular Toxicology Graduate School Of Pharmaceutical Sciences Toho
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Miyata Masaaki
Division Of Drug Metabolism & Molecular Toxicology Graduate School Of Pharmaceutical Sciences To
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MIYATA MASAAKI
Graduate School of Pharmaceutical Sciences, Tohoku University
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Tamura Etsuko
Graduate School Of Pharmaceutical Sciences Tohoku University
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Yamazoe Y
Tohoku Univ. Sendai Jpn
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TAMURA Etsuko
Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, To
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Miyata M
Graduate School Of Pharmaceutical Sciences Tohoku University
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Yamazoe Yasushi
Division Of Drug Metabolism & Molecular Toxicology Graduate School Of Pharmaceutical Sciences To
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Yamazoe Yasushi
Division Of Drug Metabolism And Molecular Toxicology Graduate School Of Pharmaceutical Sciences Toho
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