A Hydroxysteroid Sulfotransferase, St2b2, Is a Skin Cholesterol Sulfotransferase in Mice.
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概要
- 論文の詳細を見る
The mRNA of a sulfotransferase (St2b2) mediating cholesterol sulfation was detected in mouse skin. Recombinant St2b2 also mediated the sulfation of pregnenolone, 3β-hydroxy-5-cholen-24-oic acid, and dehydroepiandrosterone. St2b2 protein was detected in skin cytosols on Western blotting. The addition of 10 nM TPA to skin epidermal cells from newborn mice resulted in a twofold increase in cholesterol sulfation and concomitantly enhanced the St2b2 content after 40h. Other candidate cholesterol sulfotransferases, St2a4 and St2a9, were not detected in skin by RT-PCR. These results indicate that St2b2 is a cholesterol sulfotransferase in mouse skin.
- 社団法人 日本生化学会の論文
著者
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Nagata Kiyoshi
Division Of Drug Metabolism And Molecular Toxicology Graduate School Of Pharmaceutical Sciences Toho
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Yamazoe Yasushi
Division Of Drug Metabolism & Molecular Toxicology Graduate School Of Pharmaceutical Sciences To
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Honma Wataru
Division Of Drug Metabolism And Molecular Toxicology Graduate School Of Pharmaceutical Sciences Toho
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Kamiyama Yoshiteru
Division Of Drug Metabolism And Molecular Toxicology Graduate School Of Pharmaceutical Sciences Toho
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Sato Akira
Division Of Advanced Surgical Science And Technology Tohoku University Graduate School Of Medicine
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Shimada Miki
Division of Drug Metabolism and Molecular Toxicology, Faculty of Pharmaceutical Sciences, Tohoku University
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