RNA干渉法を用いたヒト肝チトクロムP450遺伝子の転写活性化に及ぼすPXRの寄与の評価

スポンサーリンク

概要

• 論文の詳細を見る
• 2007-08-25

著者

• Nagata Kiyoshi

  東北大学 薬学研究科薬物動態学

• Nagata Kiyoshi

  Division Of Drug Metabolism And Molecular Toxicology Graduate School Of Pharmaceutical Sciences Toho

• YAMAZOE Yasushi

  Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, To

• Yamazoe Y

  Division Of Drug Metabolism And Molecular Toxicology Graduate School Of Pharmaceutical Sciences Toho

• Yamazoe Yasushi

  Department Of Pharmacology School Of Medicine Keio University:department Of Analytical Biochemistry

• Nagata Kiyoshi

  九州大学 薬学研究院

• MATSUBARA Tsutomu

  Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, To

• KOJIMA Koki

  Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, To

• Yamazoe Yasushi

  Division Of Drug Metabolism & Molecular Toxicology Graduate School Of Pharmaceutical Sciences To

• Kojima Koki

  Division Of Drug Metabolism And Molecular Toxicology Graduate School Of Pharmaceutical Sciences Toho

• Yamazoe Yasushi

  Division Of Drug Metabolism And Molecular Toxicology Graduate School Of Pharmaceutical Sciences Toho

• Nagata K

  Department Of Environmental And Health Science Tohoku Pharmaceutical University

• Matsubara Tutomu

  Division Of Drug Metabolism And Molecular Toxicology Graduate School Of Pharmaceutical Sciences Toho

関連論文

• ヒトP450分子種の HepG2 細胞における複数同時発現 : 組換えアデノウイルスを用いたP450再構成系
• ヒト薬物動態関連遺伝子の発現に対するHNF4αの寄与をsiRNA発現アデノウイルスを用いて解析する
• MACROMOLECULAR BINDING OF CARCINOGENIC/MUTAGENIC N- HYDROXYARYLAMINES THROUGH O-ACETYLATION PATHWAY
• Tumor Necrosis Factor-Alpha–Nuclear Factor-Kappa B-Signaling Enhances St2b2 Expression during 12-O-Tetradecanoylphorbol-13-acetate-Induced Epidermal Hyperplasia
• Molecular Cloning and Characterization of Rat ST1B1 and Human ST1B2 cDNAs, Encoding Thyroid Hormone Sulfotransferases
• Formation of 2-Amino-3-methylimidazo[4,5-f]quinoline- and 2-Amino-3, 8-dimethylimidazo[4,5-f]quinoxaline-sulfamates by cDNA-expressed Mammalian Phenol Sulfotransferases
• 327 Isolation and expression of hamster acetyltransferase genes, AT-A and AT-B
• CLONING, EXPRESSION, AND FUNCTIONAL CHARACTERIZATION OF RAT AND HUMAN PHENOL SULFOTRANSFERASES
• RAT LIVER SULFOTRANSFERASE ACTIVATING CARCINOGENIC HYDROXYMETHYL-ARENES : ITS PROPERTIES AND SEQUENCE ANALYSIS OF cDNA
• Bile Acid-Induced Elevated Oxidative Stress in the Absence of Farnesoid X Receptor(Biochemistry)
• Hydroxysteroid sulfotransferase (SULT2A) の発現はFXRにより抑制的に調節される
• Bile acid sulfates as a possible early marker of liver toxicity(Drug metabolism, Proceedings of the 32nd Annual Meeting)
• Expression of hydroxysteroid sulfotransferase involved in protection against bile acid-induced hepatotoxicity(Drug metabolism, Proceedings of the 32nd Annual Meeting)
• Protection from liver toxicity induced by lithocholic acid-feeding : Involvement of cyp3a and hydroxysteroid sulfotransferase(Drug metabolism, Proceedings of the 32nd Annual Meeting)
• Bile acid-induced liver toxicity and nuclear receptor FXR (LIVER/DIGESTIVE SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
• Thalidomide-induced suppression of embryo fibroblast proliferation requires CYP1A1-mediated activation.(GENERAL SESSION BY ORAL PRESENTATION)(DRUG METABOLISM)
• O11-03 Relative importance of maternal and embryonic microsomal epoxide hydrolase in 7, 12-dimethylbenz[a] anthracene : induced developmental toxicity
• Mechanism of 7,12-Dimethylbenz[α]anthracene-Induced Immunotoxicity: Role of Metabolic Activation at the Target Organ
• O-26 Difference between Spleen and Thymus in 7, 12-Dimethylbenz[a]anthracene-lnduced lmmunotoxicity.(Proceedings of the 27th Annual Meeting)
• Construction of Several Human-derived Stable Cell Lines Displaying Distinct Profiles of CYP3A4 Induction
• Differences in Transactivation between Rat CYP3A1 and Human CYP3A4 Genes by Human Pregnane X Receptor
• A Hydroxysteroid Sulfotransferase, St2b2, Is a Skin Cholesterol Sulfotransferase in Mice
• Adenovirus Vector-Mediated Reporter System for In Vivo Analyses of Human CYP3A4 Gene Activation
• Alteration of Hepatic Sulfation by Endotoxin
• Enzymatic Characterization of Human Cytosolic Sulfotransferases : Identification of ST1B2 as a Thyroid Hormone Sulfotransferase
• Bacterial Expression and Functional Characterization of a Rat Thyroid Hormone Sulfotransferase, ST1B1
• Molecular Cloning, Expression, and Enzymatic Characterization of Rabbit Hydroxysteroid Sulfotransferase AST-RB2 (ST2A8)^1
• MECHANISM OF THE CHANGES IN HEPATIC DRUG METABOLIZING ENZYMES IN DIABETIC STATES
• REGULATION AND CHARACTERIZATION OF STEROID 6β-HYDROXYLASE IN RAT LIVERS
• B24 DRUG-INDUCED LOSS OF CONSTITUTIVE CYTOCHROME P-450 IN RAT LIVERS AND THE MECHANISM
• ROLE OF GROWTH HORMONE ON THE EXPRESSION OF SEX-SPECIFIC FORMS OF CYTOCHROME P-450,P-450-MALE AND P-450-FEMALE
• RNA干渉法を用いたヒト肝チトクロムP450遺伝子の転写活性化に及ぼすPXRの寄与の評価
• Selective Suppressions of Human CYP3A Forms, CYP3A5 and CYP3A7, by Troglitazone in HepG2 Cells
• Molecular Cloning and Expression of an Amine Sulfotransferase cDNA: A New Gene Family of Cytosolic Sulfotransferases in Mammals^1
• ラット肝臓のシトクロムP450(P450)とUDP-グルクロン酸転移酵素(UGT)のタンパク間相互作用 : P450-UGT複合体中でUGTが活性を持つことの証明
• Modulation of UDP-Glucuronosyltransferase 2B7 Function by Cytochrome P450s in Vitro : Differential Effects of CYP1A2, CYP2C9 and CYP3A4(Communications to the Editor)
• Metabolic nuclear receptor and chemical-induced liver toxicity(Proceedings of the 32nd Annual Meeting)
• Development of an In Vitro System Detecting Pro-embryotoxin
• Inhibitory Potential of Herbal Medicines on Human Cytochrome P450-Mediated Oxidation : Properties of Umbelliferous or Citrus Crude Drugs and Their Relative Prescriptions
• Inhibitory Effect of Natural Furanocoumarins on Human Microsomal Cytochrome P450 3A Activity
• Rivulobirin E and Rivulotririn C from Pleurospermum rivulorum
• TOXICOLOGICAL SIGNIFICANCE OF A FORM OF CYTOCHROME P-450 HIGHLY PURIFIED FROM LIVER MICROSOMES OF PCBTREATED RATS : CATALYTIC AND IMMUNOCHEMICAL EXAMINATIONS OF A HIGH SPIN FORM OF CYTOCHROME P-448
• The Role of Glutathione in the Activation and Detoxication of a Naturally Occurring Mutagen-Carcinogen, Trp-P-2 (Regular Presentations) (Proceedings of the 10 th Symposium on Environmental Pollutants and Toxicology)
• MECHANISMS INVOLVED IN THE COVALENT BINDING OF A TRYPTOPHAN-PYROLYSATE PROMUTAGEN, TRP-P-2,TO DNA
• Metabolic activation of amino acid-pyrolysates and its relation to mutagenicity
• STUDIES ON CYTOCHROME P-450 RESPONSIBLE FOR THE OCCURRENCE OF SEX DIFFERENCE OF DRUG METABOLISM IN THE RAT
• A SENSITIVE METHOD FOR THE DETERMINATION OF BIPHENYL HYDROXYLASE ACTIVITY AND IT'S TOXICOLOGICAL APPLICATION
• MECHANISMS OF METABOLIC ACTIVATION OF A TRYPTOPHAN PYROLYSATE, 3-AMINO-1-METHYL-5H-PYRIDO [4,3-b] INDOLE
• PURIFICATION AND PROPERTIES OF CYTOCHROME P-450 AND NADPH-CYTOCHROME C (P-450) REDUCTASE FROM MICROSOMES OF HUMAN LIVERS
• STUDIES ON THE METABOLIC ACTIVATION AND THE MECHANISM OF TOXICITY OF DRUGS V. REDUCTION OF N-HYDROXY DERIVATIVE OF AN AROMATIC AMINE, 2-ACETYLAMINOFLUORENE BY CYTOCHROME P-450 (The 6th Meeting for the Study of Toxic Effect)
• DEGRADATION OF CYTOCHROME P-450 ASSOCIATED WITH METABOLIC ACTIVATION OF CARBON TETRACHLORIDE (The 5th Meeting for the Study of Toxic Effect)
• Metabolism of N, N-Dipropyl-2-[4-Methoxy-3-(2-Phenyl-Ethoxy)-Phenyl]-Ethyl-Amine-Monohydrochloride(NE-100), A Novel Sigma Ligand : Contribution of Cytochrome P450 Forms Involved in the Formation of Individual Metabolites in Human Liver and Small Intestine
• Grapefruit Component Interacting with Rat and Human P450 CYP3A : Possible Involvement of Non-Flavonoid Components in Drug Interaction
• Effects of Serum Albumin and Liver Cytosol on CYP2C9-and CYP3A4-mediated Drug Metabolism
• Interferon-γ modulate Ia antigen expression on thymic reticuloepithelial cells in New Zealand mice
• Metabolic activation of chemicals in various organs as key events for tissue specific toxicities(SYMPOSIUM 1 : MECHANISMS OF HEPATOTOXIC EFFECTS)
• Construction of a System that Simultaneously Evaluates CYP1A1 and CYP1A2 Induction in a Stable Human-derived Cell Line using a Dual Reporter Plasmid
• THE APPARENT LOSS OF CYTOCHROME P-450 ASSOCIATED WITH METABOLIC ACTIVATION OF CARBON TETRACHLORIDE
• Fibroblast Growth Factor 19 Treatment Ameliorates Disruption of Hepatic Lipid Metabolism in Farnesoid X Receptor (Fxr)-Null Mice
• Adenovirus Vector-Mediated Reporter System for In Vivo Analyses of Human CYP3A4 Gene Activation.
• A Hydroxysteroid Sulfotransferase, St2b2, Is a Skin Cholesterol Sulfotransferase in Mice.
• Molecular Cloning and Characterization of Rat ST1B1 and Human ST1B2 cDNAs, Encoding Thyroid Hormone Sulfotransferases.

もっと見る 閉じる

スポンサーリンク