Alteration of Hepatic Sulfation by Endotoxin
スポンサーリンク
概要
- 論文の詳細を見る
Administration of an endotoxin, lipopolysaccharide (1 mg/kg body weight), caused decreases in hepatic sulfations of xenobiotics in male rats through changes in the amounts of at least three forms of sulfotransferases, ST1A1, ST1B1 and ST1C1. The time-dependent decrease was first observed with ST1B1, followed by ST1A1 and ST1C1; and the decrease was more profound in the levels of mRNAs than those of proteins. The decreases in their mRNAs were, however, prevented by the pretreatment with dexamethasone. These results suggest that the endotoxin suppresses the hepatic sulfation through a cytokine-mediated mechanism to change individually hepatic levels of ST1A1, ST1B1 and ST1C1.
- 社団法人 日本薬理学会の論文
- 1999-08-01
著者
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Nagata Kiyoshi
東北大学 薬学研究科薬物動態学
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Nagata Kiyoshi
Division Of Drug Metabolism And Molecular Toxicology Graduate School Of Pharmaceutical Sciences Toho
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YAMAZOE Yasushi
Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, To
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Yamazoe Y
Division Of Drug Metabolism And Molecular Toxicology Graduate School Of Pharmaceutical Sciences Toho
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Yamazoe Yasushi
Department Of Pharmacology School Of Medicine Keio University:department Of Analytical Biochemistry
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Nagata Kiyoshi
九州大学 薬学研究院
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Shimada Miki
Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, To
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Shimada M
Division Of Drug Metabolism And Molecular Toxicology Graduate School Of Pharmaceutical Sciences Toho
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WATANABE Eriko
Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, To
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IIDA Yuka
Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, To
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Watanabe Etsushi
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Shimada Miki
Department Of Pharmacology School Of Medicine Keio University
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Yamazoe Yasushi
Division Of Drug Metabolism & Molecular Toxicology Graduate School Of Pharmaceutical Sciences To
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Iida Yuka
Division Of Drug Metabolism And Molecular Toxicology Graduate School Of Pharmaceutical Sciences Toho
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Watanabe Eriko
Department Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Yamazoe Yasushi
Division Of Drug Metabolism And Molecular Toxicology Graduate School Of Pharmaceutical Sciences Toho
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Nagata K
Department Of Environmental And Health Science Tohoku Pharmaceutical University
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Shimada Mitsuyo
Department Of Physiology Teikyo University School Of Medicine
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Shimada Miki
Division of Drug Metabolism and Molecular Toxicology, Faculty of Pharmaceutical Sciences, Tohoku University
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