Metabolic activation of amino acid-pyrolysates and its relation to mutagenicity
スポンサーリンク
概要
- 論文の詳細を見る
- 日本トキシコロジー学会の論文
- 1982-11-25
著者
-
Yamazoe Yasushi
Department Of Pharmacology School Of Medicine Keio University:department Of Analytical Biochemistry
-
Kato Ryuichi
Department Of Pharmacology School Of Medicine Keio University
-
YAMAZOE Yasushi
Dept. of Pharmacol., School of Med., Keio Univ.
-
KATO Ryuichi
Dept. of Pharmacol., School of Med., Keio Univ.
-
Kato Ryuichi
Dept. Of Pharmacol. School Of Med. Keio Univ.
-
Kamataki Tetsuya
Department Of Pharmacology School Of Medicine Keio University:department Of Analytical Biochemistry
-
KAMATAKI Tetsuya
Dept. of Pharmacol., Sch. of Med., Keio University
-
Kamataki Tetsuya
Division Of Analytical Biochemistry Faculty Of Pharmaceutical Sciences Hokkaido University
-
Kamataki Tetsuya
Department Of Pharmacology School Of Medicine Keio University
-
Yamazoe Yasushi
Dept. Of Pharmacol. Sch. Of Med. Keio University
-
Kamataki Tetsuya
Lab. Drug Metab. Fac. Pharm. Sci. Hokkaido University
関連論文
- ヒトP450分子種の HepG2 細胞における複数同時発現 : 組換えアデノウイルスを用いたP450再構成系
- ヒト薬物動態関連遺伝子の発現に対するHNF4αの寄与をsiRNA発現アデノウイルスを用いて解析する
- MACROMOLECULAR BINDING OF CARCINOGENIC/MUTAGENIC N- HYDROXYARYLAMINES THROUGH O-ACETYLATION PATHWAY
- MECHANISM OF MUTATION AND METABOLIC ACTIVATION OF NITRO-, NITROSO-, HYDROXYLAMINO-COMPOUNDS IN NITRO-COMPOUNDS RESISTANT MUTANTS OF AMES TESTAR STRAIN (TA98NR, TA98/1,8-DNP_6)
- O11-01 Induction of Human CYP1A1 by 2-Phenyl-benzotriazoles(PBTAs)which Are Metabolically Activated by CYP1A1
- O-18 Role of Human N-Acetyltransferase in the Metabolic Activation of 2-Phenylbenzotriazole (PBTA) Derivatives.(Proceedings of the 27th Annual Meeting)
- 21C-01-1 Metabolic Activation of PBTA-1 and PBTA-2 by Human Cytochrome P450 1A1.
- Molecular Cloning and Characterization of Rat ST1B1 and Human ST1B2 cDNAs, Encoding Thyroid Hormone Sulfotransferases
- Formation of 2-Amino-3-methylimidazo[4,5-f]quinoline- and 2-Amino-3, 8-dimethylimidazo[4,5-f]quinoxaline-sulfamates by cDNA-expressed Mammalian Phenol Sulfotransferases
- 327 Isolation and expression of hamster acetyltransferase genes, AT-A and AT-B
- CLONING, EXPRESSION, AND FUNCTIONAL CHARACTERIZATION OF RAT AND HUMAN PHENOL SULFOTRANSFERASES
- RAT LIVER SULFOTRANSFERASE ACTIVATING CARCINOGENIC HYDROXYMETHYL-ARENES : ITS PROPERTIES AND SEQUENCE ANALYSIS OF cDNA
- Bile Acid-Induced Elevated Oxidative Stress in the Absence of Farnesoid X Receptor(Biochemistry)
- Hydroxysteroid sulfotransferase (SULT2A) の発現はFXRにより抑制的に調節される
- Bile acid sulfates as a possible early marker of liver toxicity(Drug metabolism, Proceedings of the 32nd Annual Meeting)
- Expression of hydroxysteroid sulfotransferase involved in protection against bile acid-induced hepatotoxicity(Drug metabolism, Proceedings of the 32nd Annual Meeting)
- Protection from liver toxicity induced by lithocholic acid-feeding : Involvement of cyp3a and hydroxysteroid sulfotransferase(Drug metabolism, Proceedings of the 32nd Annual Meeting)
- Bile acid-induced liver toxicity and nuclear receptor FXR (LIVER/DIGESTIVE SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Thalidomide-induced suppression of embryo fibroblast proliferation requires CYP1A1-mediated activation.(GENERAL SESSION BY ORAL PRESENTATION)(DRUG METABOLISM)
- O11-03 Relative importance of maternal and embryonic microsomal epoxide hydrolase in 7, 12-dimethylbenz[a] anthracene : induced developmental toxicity
- Mechanism of 7,12-Dimethylbenz[α]anthracene-Induced Immunotoxicity: Role of Metabolic Activation at the Target Organ
- O-26 Difference between Spleen and Thymus in 7, 12-Dimethylbenz[a]anthracene-lnduced lmmunotoxicity.(Proceedings of the 27th Annual Meeting)
- Construction of Several Human-derived Stable Cell Lines Displaying Distinct Profiles of CYP3A4 Induction
- Differences in Transactivation between Rat CYP3A1 and Human CYP3A4 Genes by Human Pregnane X Receptor
- A Hydroxysteroid Sulfotransferase, St2b2, Is a Skin Cholesterol Sulfotransferase in Mice
- Adenovirus Vector-Mediated Reporter System for In Vivo Analyses of Human CYP3A4 Gene Activation
- Alteration of Hepatic Sulfation by Endotoxin
- Enzymatic Characterization of Human Cytosolic Sulfotransferases : Identification of ST1B2 as a Thyroid Hormone Sulfotransferase
- Bacterial Expression and Functional Characterization of a Rat Thyroid Hormone Sulfotransferase, ST1B1
- Molecular Cloning, Expression, and Enzymatic Characterization of Rabbit Hydroxysteroid Sulfotransferase AST-RB2 (ST2A8)^1
- MECHANISM OF THE CHANGES IN HEPATIC DRUG METABOLIZING ENZYMES IN DIABETIC STATES
- REGULATION AND CHARACTERIZATION OF STEROID 6β-HYDROXYLASE IN RAT LIVERS
- B24 DRUG-INDUCED LOSS OF CONSTITUTIVE CYTOCHROME P-450 IN RAT LIVERS AND THE MECHANISM
- ROLE OF GROWTH HORMONE ON THE EXPRESSION OF SEX-SPECIFIC FORMS OF CYTOCHROME P-450,P-450-MALE AND P-450-FEMALE
- STUDIES ON SEX-SPECIFIC FORMS OF CYTOCHROME P-450 IN MALE AND FEMALE RATS
- RNA干渉法を用いたヒト肝チトクロムP450遺伝子の転写活性化に及ぼすPXRの寄与の評価
- Selective Suppressions of Human CYP3A Forms, CYP3A5 and CYP3A7, by Troglitazone in HepG2 Cells
- Molecular Cloning and Expression of an Amine Sulfotransferase cDNA: A New Gene Family of Cytosolic Sulfotransferases in Mammals^1
- Metabolic nuclear receptor and chemical-induced liver toxicity(Proceedings of the 32nd Annual Meeting)
- Inhibitory Effects of Nicardipine to Cytochrome P450 (CYP) in Human Liver Microsomes(Biopharmacy)
- Co-operative Regulation of the Transcription of Human Dihydrodiol Dehydrogenase(DD)4/Aldo-Keot Reductase(AKR)1C4 Gene by Hepatocyte Nuclear Factor(HNF)-4α/γand HNF-1α.
- Characterization of a Novel Variant (S145C/L311V) of 3α-Hydroxysteroid/Dihydrodiol Dehydrogenase in Human Liver.
- Expression and Characterization of Dog CYP2D15 Using Baculovirus Expression System^1
- Cloning and characterization of the radA gene from a hyperthermophilic archaeon Pyrobaculum islandicum.
- Development of an In Vitro System Detecting Pro-embryotoxin
- AHR-mediated suppression of PPARα target gene expression caused by exposed polycyclic aromatic hydrocarbons (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- 2B-08 Establishment of Genetically Engineered E.coli Highly Sensitive to Nitrosamines by Introducing Human CYP2E1
- Inhibitory Potential of Herbal Medicines on Human Cytochrome P450-Mediated Oxidation : Properties of Umbelliferous or Citrus Crude Drugs and Their Relative Prescriptions
- Inhibitory Effect of Natural Furanocoumarins on Human Microsomal Cytochrome P450 3A Activity
- Rivulobirin E and Rivulotririn C from Pleurospermum rivulorum
- STEREOSELECTIVE HYDROXYLATION OF MEPHENYTOIN IN HUMAN LIVERS : CLONING AND EXPRESSION OF MEPHENYTOIN HYDROXYLASE cDNAS IN YEASTS AND THE GENETIC POLYMORPHISM
- S-5 CURRENT TOPICS OF SPECIES SPECIFICITY IN DRUG TOXICITY-METABOLIC ASPECT
- TOXICOLOGICAL SIGNIFICANCE OF A FORM OF CYTOCHROME P-450 HIGHLY PURIFIED FROM LIVER MICROSOMES OF PCBTREATED RATS : CATALYTIC AND IMMUNOCHEMICAL EXAMINATIONS OF A HIGH SPIN FORM OF CYTOCHROME P-448
- The Role of Glutathione in the Activation and Detoxication of a Naturally Occurring Mutagen-Carcinogen, Trp-P-2 (Regular Presentations) (Proceedings of the 10 th Symposium on Environmental Pollutants and Toxicology)
- MECHANISMS INVOLVED IN THE COVALENT BINDING OF A TRYPTOPHAN-PYROLYSATE PROMUTAGEN, TRP-P-2,TO DNA
- Metabolic activation of amino acid-pyrolysates and its relation to mutagenicity
- STUDIES ON CYTOCHROME P-450 RESPONSIBLE FOR THE OCCURRENCE OF SEX DIFFERENCE OF DRUG METABOLISM IN THE RAT
- A SENSITIVE METHOD FOR THE DETERMINATION OF BIPHENYL HYDROXYLASE ACTIVITY AND IT'S TOXICOLOGICAL APPLICATION
- MECHANISMS OF METABOLIC ACTIVATION OF A TRYPTOPHAN PYROLYSATE, 3-AMINO-1-METHYL-5H-PYRIDO [4,3-b] INDOLE
- PURIFICATION AND PROPERTIES OF CYTOCHROME P-450 AND NADPH-CYTOCHROME C (P-450) REDUCTASE FROM MICROSOMES OF HUMAN LIVERS
- STUDIES ON THE METABOLIC ACTIVATION AND THE MECHANISM OF TOXICITY OF DRUGS V. REDUCTION OF N-HYDROXY DERIVATIVE OF AN AROMATIC AMINE, 2-ACETYLAMINOFLUORENE BY CYTOCHROME P-450 (The 6th Meeting for the Study of Toxic Effect)
- DEGRADATION OF CYTOCHROME P-450 ASSOCIATED WITH METABOLIC ACTIVATION OF CARBON TETRACHLORIDE (The 5th Meeting for the Study of Toxic Effect)
- Application of Primary Hepatocytes from p53-Knockout Mice for Studies of Expression of Cyp3a
- Expression of human CYP1A2 capable of activating heterocyclic amine in Bm 6 cells using baculovirus (BmNPV) system.
- Genetic Polymorphism in the 5'-Flanking Region of Human CYP1A2 Gene : Effect on the CYP1A2 Inducibility in Humans
- METABOLIC ACTIVATION OF AFLATOXIN B_1 BY HUMAN PLACENTAL MICROSOMES
- Formation of an Antibacterial Metabolite from a New Macrolide Compound 23-O-Benzyl-5-mycaminosyl-tylonolide (TMC-101), by a Hepatic Microsomal Drug-Metabolizing Enzyme System
- 5-2) MOLECULAR TOXICOLOGY ON CYTOCHROME P-450 IN HUMAN FETAL LIVERS
- Immunochemical Studies for the Presence of P-450 HFLa, a Form of Cytochrome P-450 in Human Fetal Livers in Human Hepatocellular Carcinoma Cells
- SPECIES DIFFERENCE OF CYTOCHROME (S) P-450 CROSS-REACTIVE WITH ANTI-P-450-MALE ANTIBODIES
- Large-scale Production of Genetically Engineered CYP3A4 in E. coli: Application of a Jarfermenter
- 21C-04-1 Inhibition of the Activity of Human Cytochrome P450 Involved in the Metabolic Activation of Procarcinogens by Green Tea Catechins.
- Establishment of Salmonella Tester Strains Co-expressing Cytochrome P450 and NADPH-cytochrome P450 Reductase.
- Application of Genetically Engineered Bacteria Carrying Human Cytochrome P450 to Toxicological Studies
- Metabolic Activation of Dimethylnitrosamine(DMN) by Human CYP2E1 Expressed in O^6-Methylguanine-DNA Methyltransferase-Deficient Cells
- Establishment Of A Salmonella Tester Strain Ultra-Sensitive To Mutagenic Heterocyclic Amines
- DEVELOPMENT OF PRACTICAL METHODS WHICH MIMIC DRUG METABOLISM IN HUMANS.
- "S2-3 STRATEGIC PROPOSALS TO AVOID TOXIC DRUG INTERACTIONS DURING NEW DRUG DEVELOPMENT : MOLECULAR TOXICOLOGY PROPOSALS (Strategy how we can learn drug-drug interaction during the development of a new drug)
- Stable expression of CYP3A4 and CYP3A7, adult and fetal-specific forms of cytochrome P450 in human liver, in CHL cells and its application to toxicological testing.
- Effects of NO-1886 (Ibrolipim), a Lipoprotein Lipase-Promoting Agent, on Gene Induction of Cytochrome P450s, Carboxylesterases, and Sulfotransferases in Primary Cultures of Human Hepatocytes
- 221 INTRODUCTION OF CYTOCHROME P-450 cDNAS INTO CULTURED MAMMALIAN CELLS AND THEIR APPLICATION TO IN VITRO TOXICOLOGICAL STUDIES
- Preventive Effects of Hange-shashin-to on Irinotecan Hydrochloride-Caused Diarrhea and Its Relevance to the Colonic Prostaglandin E_2 and Water Absorption in the Rat
- METABOLISM AND ACTIVATION OF AFLATOXIN B_1 IN RECONSTITUTED CYTOCHROME P-450 SYSTEM OF RAT LIVER
- Protective Effects of Kampo Medicines and Baicalin against Intestinal Toxicity of a New Anticancer Camptothecin Derivative, Irinotecan Hydrochloride (CPT-11), in Rats
- Interferon-γ modulate Ia antigen expression on thymic reticuloepithelial cells in New Zealand mice
- CHEMICAL-INDUCED DAMAGE OF BIOLOGICAL MACROMOLECULE AND THE MODULATION (particularly on the activation pathway of primary arylamine) (Biochemical background for mechanisms of toxicity)
- Metabolism of Selegiline Hydrochloride, a Selective Monoamine B-type Inhibitor, in Human Liver Microsomes
- A04 EFFECTS OF METYRAPONE ON THE CYTOCHROME P450 MEDIATED DRUG METABOLIZING ACTIVITIES IN THE PRIMARY CULTURES OF RAT HEPATOCYTES
- OCCURRENCE OF AUTOANTIBODY TO PROTEIN DISULFIDE ISOMERASE IN PATIENTS WITH HEPATIC DISORDER
- OCCURRENCE OF AUTOANTIBODY TO PROTEIN DISULFIDE ISOMERASE IN RATS WITH XENOBIOTIC-INDUCED HEPATITIS
- Relevance of Irinotecan Hydrochloride-Induced Diarrhea to the Level of Prostaglandin E_2 and Water Absorption of Large Intestine in Rats
- MOLECULAR CLONING OF MOUSE LIVER FLAVIN CONTAINING MONOOXYGENASE (FMO1) cDNA AND CHARACTERIZATION OF THE EXPRESSION PRODUCT : METABOLISM OF THE NEUROTOXIN, 1,2,3,4- TETRAHYDROISOQUINOLINE (TIQ)
- HIGH SUSCEPTIBILITY TO AFLATOXIN B_1 AND BENZO[A]PYRENE OF BALB3T3 A31-1-1 CELLS EXPRESSING MONKEY CYP1A1
- LOW ACTIVITY OF ALDEHYDE DEHYDROGENASE (ALDH) IN LIVER OF SUNCUS MURlNUS : POSSIBLE EXPLANATION FOR HIGH SENSITIVITY TO ALCOHOL
- Inhibition of UDP-glucuronosyltransferase by Aglycons of Natural Glucuronides in Kampo Medicines Using SN-38 as a Substrate
- INHIBITION BY SKF 525-A OF 7-ETHOXYCOUMARIN O-DEETHYLATION IN MICROSOMAL AND THE RECONSTITUTED MONOOXYGENASE SYSTEMS FROM PCB-TREATED RAT LIVERS
- TOXICOLOGICAL AND BIOCHEMICAL STUDIES OF THE 12-0-TETRADECANOYLPHORBOL-13-ACETATE-INDUCED ACTIONS
- METABOLIC ACTIVATION AND INACTIVATION BY CYTOCHROME P-450 (Biochemical background for mechanisms of toxicity)
- THE APPARENT LOSS OF CYTOCHROME P-450 ASSOCIATED WITH METABOLIC ACTIVATION OF CARBON TETRACHLORIDE
- Interspecies homology of cytochrome P-450: Inhibition by anti-P-450-Male antibodies of testosterone hydroxylases in liver microsomes from various animal species including man.