Expression of human CYP1A2 capable of activating heterocyclic amine in Bm 6 cells using baculovirus (BmNPV) system.

スポンサーリンク

概要

• 論文の詳細を見る
• 日本トキシコロジー学会の論文
• 1995-09-25

著者

• GONZALEZ Frank

  Laboratory of Metabolism, National Cancer Institute, National Institutes of Health

• Nakayama K

  Department Of Molecular And Cellular Biology Medical Institute Of Bioregulation Kyushu University

• Sakuma Tsutomu

  Division of Thoracic Surgery, Kanazawa Medical University

• ITOH Susumu

  Division of Drug Metabolism, Faculty of Pharmaceuti-cal Sciences, Hokkaido University

• KAMATAKI Tetsuya

  Division of Drug Metabolism, Faculty of Pharmaceuti-cal Sciences, Hokkaido University

• Kamataki T

  Hokkaido Univ. Sapporo Jpn

• Kamataki Tetsuya

  Department Of Pharmacology School Of Medicine Keio University:department Of Analytical Biochemistry

• Kamataki Tetsuya

  Division Of Drug Metabolism Faculty Of Pharmaceutical Sciences Hokkaido University

• NAKAYAMA Kazuo

  Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Hokkaido University

• Inano Keiko

  Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Hokkaido Univ.

• Gonzalez Frank

  Laboratory Of Molecular Carcinogenesis National Institutes Of Health

• Kamataki Tetsuya

  Division Of Analytical Biochemistry Faculty Of Pharmaceutical Sciences Hokkaido University

• Itoh Susumu

  Division Of Drug Metabolism Faculty Of Pharmaceutical Sciences Hokkaido University

• Sakuma Tsutomu

  Division Of Drug Metabolism Faculty Of Pharmaceutical Sciences Hokkaido Univ.

• Gonzalez Frank

  Laboratory Of Metabolism Division Of Basic Science National Cancer Institute

• Inano Keiko

  Division Of Drug Metabolism Faculty Of Pharmaceutical Sciences Hokkaido Univ.

• Itoh Susumu

  Division Of Cellular Physiology Faculty Of Pharmaceutical Sciences Osaka University

• Kamataki Tetsuya

  Lab. Drug Metab. Fac. Pharm. Sci. Hokkaido University

• Nakayama Kazuo

  Division Of Drug Metabolism Faculty Of Pharmaceutical Sciences Hokkaido University

関連論文

• Di(2-ethylhexyl)phthalate Induces Hepatic Tumorigenesis through a Peroxisome Proliferator-activated Receptor α-independent Pathway
• Different Mechanisms of DEHP-induced Hepatocellular Adenoma Tumorigenesis in Wild-type and Pparα-null Mice
• Regulation of Hepatocyte Nuclear Factor 4α-mediated Transcription
• MACROMOLECULAR BINDING OF CARCINOGENIC/MUTAGENIC N- HYDROXYARYLAMINES THROUGH O-ACETYLATION PATHWAY
• MECHANISM OF MUTATION AND METABOLIC ACTIVATION OF NITRO-, NITROSO-, HYDROXYLAMINO-COMPOUNDS IN NITRO-COMPOUNDS RESISTANT MUTANTS OF AMES TESTAR STRAIN (TA98NR, TA98/1,8-DNP_6)
• Two Novel Single Nucleotide Polymorphisms (SNPs) of the FMO3 Gene in Japanese
• A Mutation in the Flavin-containing Monooxygenase 3 Gene and its Effects on Catalytic Activity for N-oxidation of Trimethylamine In Vitro
• Differential Effects of Aging, Drinking and Exercise on Serum Cholesterol Levels Dependent on the PPARA-V227A Polymorphism
• Overexpression of CYP2A6 in human colorectal tumors
• O11-01 Induction of Human CYP1A1 by 2-Phenyl-benzotriazoles(PBTAs)which Are Metabolically Activated by CYP1A1
• O-18 Role of Human N-Acetyltransferase in the Metabolic Activation of 2-Phenylbenzotriazole (PBTA) Derivatives.(Proceedings of the 27th Annual Meeting)
• 21C-01-1 Metabolic Activation of PBTA-1 and PBTA-2 by Human Cytochrome P450 1A1.
• Establishment of in silico systems to predict the effects of genetic polymorphism on the enzymatic activity of cytochrome P450
• Bile Acid-Induced Elevated Oxidative Stress in the Absence of Farnesoid X Receptor(Biochemistry)
• Hydroxysteroid sulfotransferase (SULT2A) の発現はFXRにより抑制的に調節される
• Bile acid sulfates as a possible early marker of liver toxicity(Drug metabolism, Proceedings of the 32nd Annual Meeting)
• Expression of hydroxysteroid sulfotransferase involved in protection against bile acid-induced hepatotoxicity(Drug metabolism, Proceedings of the 32nd Annual Meeting)
• Protection from liver toxicity induced by lithocholic acid-feeding : Involvement of cyp3a and hydroxysteroid sulfotransferase(Drug metabolism, Proceedings of the 32nd Annual Meeting)
• Bile acid-induced liver toxicity and nuclear receptor FXR (LIVER/DIGESTIVE SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
• O11-03 Relative importance of maternal and embryonic microsomal epoxide hydrolase in 7, 12-dimethylbenz[a] anthracene : induced developmental toxicity
• Mechanism of 7,12-Dimethylbenz[α]anthracene-Induced Immunotoxicity: Role of Metabolic Activation at the Target Organ
• O-26 Difference between Spleen and Thymus in 7, 12-Dimethylbenz[a]anthracene-lnduced lmmunotoxicity.(Proceedings of the 27th Annual Meeting)
• ROLE OF GROWTH HORMONE ON THE EXPRESSION OF SEX-SPECIFIC FORMS OF CYTOCHROME P-450,P-450-MALE AND P-450-FEMALE
• STUDIES ON SEX-SPECIFIC FORMS OF CYTOCHROME P-450 IN MALE AND FEMALE RATS
• Effects of α_1-, β_1-, β_2-, β_3-Adrenergic Agonists on Alveolar Fluid Clearance in Isolated Rat Lungs
• Inhibitory Effects of Nicardipine to Cytochrome P450 (CYP) in Human Liver Microsomes(Biopharmacy)
• Co-operative Regulation of the Transcription of Human Dihydrodiol Dehydrogenase(DD)4/Aldo-Keot Reductase(AKR)1C4 Gene by Hepatocyte Nuclear Factor(HNF)-4α/γand HNF-1α.
• Characterization of a Novel Variant (S145C/L311V) of 3α-Hydroxysteroid/Dihydrodiol Dehydrogenase in Human Liver.
• Expression and Characterization of Dog CYP2D15 Using Baculovirus Expression System^1
• Structure and Intracellular Localization of Mouse ADP-Ribosylation Factors Type 1 to Type 6 (ARF1-ARF6)
• CYP2A6 gene deletion reduces oral cancer risk in betel quid chewers.(GENERAL SESSION BY ORAL PRESENTATION)(DRUG METABOLISM)
• AHR-mediated suppression of PPARα target gene expression caused by exposed polycyclic aromatic hydrocarbons (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
• SUPPRESSION OF PPAR ALPHA SIGNAL CAUSED BY POLYCYCLIC AROMATIC HYDROCARBONS.(GENERAL SESSION BY POSTER PRESENTATION)(MOLECULAR TOXICITY & TOXICOGENOMICS)
• 2B-08 Establishment of Genetically Engineered E.coli Highly Sensitive to Nitrosamines by Introducing Human CYP2E1
• Tuna Muscle Peptide, PTHIKWGD, Inhibits Leukocyte-Mediated Injury and Leukocyte Adhesion to Cultured Endothelial Cells
• Increase of Cytochrome b mRNA by Bis(2-hydroxyethyl) Trisulfide in J774A.1 Cells
• CYP3A5 Contributes Significantly to CYP3A-mediated Drug Oxidations in Liver Microsomes from Japanese Subjects
• TOXICOLOGICAL SIGNIFICANCE OF A FORM OF CYTOCHROME P-450 HIGHLY PURIFIED FROM LIVER MICROSOMES OF PCBTREATED RATS : CATALYTIC AND IMMUNOCHEMICAL EXAMINATIONS OF A HIGH SPIN FORM OF CYTOCHROME P-448
• The Role of Glutathione in the Activation and Detoxication of a Naturally Occurring Mutagen-Carcinogen, Trp-P-2 (Regular Presentations) (Proceedings of the 10 th Symposium on Environmental Pollutants and Toxicology)
• MECHANISMS INVOLVED IN THE COVALENT BINDING OF A TRYPTOPHAN-PYROLYSATE PROMUTAGEN, TRP-P-2,TO DNA
• Metabolic activation of amino acid-pyrolysates and its relation to mutagenicity
• STUDIES ON CYTOCHROME P-450 RESPONSIBLE FOR THE OCCURRENCE OF SEX DIFFERENCE OF DRUG METABOLISM IN THE RAT
• A SENSITIVE METHOD FOR THE DETERMINATION OF BIPHENYL HYDROXYLASE ACTIVITY AND IT'S TOXICOLOGICAL APPLICATION
• MECHANISMS OF METABOLIC ACTIVATION OF A TRYPTOPHAN PYROLYSATE, 3-AMINO-1-METHYL-5H-PYRIDO [4,3-b] INDOLE
• PURIFICATION AND PROPERTIES OF CYTOCHROME P-450 AND NADPH-CYTOCHROME C (P-450) REDUCTASE FROM MICROSOMES OF HUMAN LIVERS
• STUDIES ON THE METABOLIC ACTIVATION AND THE MECHANISM OF TOXICITY OF DRUGS V. REDUCTION OF N-HYDROXY DERIVATIVE OF AN AROMATIC AMINE, 2-ACETYLAMINOFLUORENE BY CYTOCHROME P-450 (The 6th Meeting for the Study of Toxic Effect)
• DEGRADATION OF CYTOCHROME P-450 ASSOCIATED WITH METABOLIC ACTIVATION OF CARBON TETRACHLORIDE (The 5th Meeting for the Study of Toxic Effect)
• Application of Primary Hepatocytes from p53-Knockout Mice for Studies of Expression of Cyp3a
• Expression of human CYP1A2 capable of activating heterocyclic amine in Bm 6 cells using baculovirus (BmNPV) system.
• In vivo Evaluation of Coumarin and Nicotine as Probe Drugs to Predict the Metabolic Capacity of CYP2A6 Due to Genetic Polymorphism in Thais
• Novel Nonsynonymous Polymorphisms of the CYP1A1 Gene in Japanese
• Toxicological roles of human and rodent CYP2As in the mutagenic activation of N-nitrosamines.(GENERAL SESSION BY ORAL PRESENTATION)(DRUG METABOLISM)
• Novel Mutations of the CYP2A6 Gene in a Thai Population with Lowered Capacity of Coumarin 7-Hydroxylation
• O11-15 Mutagenic activation of tobacco-related N-nitrosamines by rat CYP2As in comparison with human CYP2A6.
• O11-14 Comparison of the toxicolqical roles of mouse CYP2A with human CYP2A6.
• Genetic Polymorphism in the 5'-Flanking Region of Human CYP1A2 Gene : Effect on the CYP1A2 Inducibility in Humans
• METABOLIC ACTIVATION OF AFLATOXIN B_1 BY HUMAN PLACENTAL MICROSOMES
• Formation of an Antibacterial Metabolite from a New Macrolide Compound 23-O-Benzyl-5-mycaminosyl-tylonolide (TMC-101), by a Hepatic Microsomal Drug-Metabolizing Enzyme System
• 5-2) MOLECULAR TOXICOLOGY ON CYTOCHROME P-450 IN HUMAN FETAL LIVERS
• Immunochemical Studies for the Presence of P-450 HFLa, a Form of Cytochrome P-450 in Human Fetal Livers in Human Hepatocellular Carcinoma Cells
• SPECIES DIFFERENCE OF CYTOCHROME (S) P-450 CROSS-REACTIVE WITH ANTI-P-450-MALE ANTIBODIES
• Large-scale Production of Genetically Engineered CYP3A4 in E. coli: Application of a Jarfermenter
• 21C-04-1 Inhibition of the Activity of Human Cytochrome P450 Involved in the Metabolic Activation of Procarcinogens by Green Tea Catechins.
• Establishment of Salmonella Tester Strains Co-expressing Cytochrome P450 and NADPH-cytochrome P450 Reductase.
• Application of Genetically Engineered Bacteria Carrying Human Cytochrome P450 to Toxicological Studies
• Metabolic Activation of Dimethylnitrosamine(DMN) by Human CYP2E1 Expressed in O^6-Methylguanine-DNA Methyltransferase-Deficient Cells
• Establishment Of A Salmonella Tester Strain Ultra-Sensitive To Mutagenic Heterocyclic Amines
• DEVELOPMENT OF PRACTICAL METHODS WHICH MIMIC DRUG METABOLISM IN HUMANS.
• EXPRESSION OF RECOMBINANT HUMAN CYTOCHROME P450 (P450 OR CYP) 2A6 IN ESCHERICHIA COLI.
• "S2-3 STRATEGIC PROPOSALS TO AVOID TOXIC DRUG INTERACTIONS DURING NEW DRUG DEVELOPMENT : MOLECULAR TOXICOLOGY PROPOSALS (Strategy how we can learn drug-drug interaction during the development of a new drug)
• Stable expression of CYP3A4 and CYP3A7, adult and fetal-specific forms of cytochrome P450 in human liver, in CHL cells and its application to toxicological testing.
• Effects of NO-1886 (Ibrolipim), a Lipoprotein Lipase-Promoting Agent, on Gene Induction of Cytochrome P450s, Carboxylesterases, and Sulfotransferases in Primary Cultures of Human Hepatocytes
• Gingipains Inactivate a Cell Surface Ligand on Porphyromonas gingivalis That Induces TLR2- and TLR4-Independent Signaling
• Regulation of insulin-like growth factor binding protein-1 and lipoprotein lipase by the aryl hydrocarbon receptor
• SL1 The role of the aryl hydrocarbon receptor in animal development, physiological homeostasis and toxicity of TCDD
• Mechanical stress on type II alveolar epithelial cells and production of CXC chemokines
• 221 INTRODUCTION OF CYTOCHROME P-450 cDNAS INTO CULTURED MAMMALIAN CELLS AND THEIR APPLICATION TO IN VITRO TOXICOLOGICAL STUDIES
• Impaired chemotaxis and cell adhesion due to decrease in several cell-surface receptors in cathepsin E-deficient macrophages.
• Cathepsin E-Deficient Mice Show Increased Susceptibility to Bacterial Infection Associated with the Decreased Expression of Multiple Cell Surface Toll-Like Receptors
• Analysis of Amphotericin B-Induced Cell Signaling with Chemical Inhibitors of Signaling Molecules
• Association of Cathepsin E Deficiency with Development of Atopic Dermatitis
• Porphyromonas gingivalis Proteinases as Virulence Determinants in Progressin of Periodonatal Diseases
• Biochemical and Functional Properties of Lysine-Specific Cysteine Proteinase(Lys-Gingipain)as a Virulence Factor of Porphyromonas gingivalis in Periodontal Disease^1
• Cloning and Sequencing of the Gene Encolding a Novel Lysine-Specific Cysteine Proteinase (Lys-Gingipain)in Porphyromonas gingivalis: Structural Relationship with the Arginine-Specific Cysteine Proteinase(Arg-Gingipain)
• Preventive Effects of Hange-shashin-to on Irinotecan Hydrochloride-Caused Diarrhea and Its Relevance to the Colonic Prostaglandin E_2 and Water Absorption in the Rat
• Protective Effects of Kampo Medicines and Baicalin against Intestinal Toxicity of a New Anticancer Camptothecin Derivative, Irinotecan Hydrochloride (CPT-11), in Rats
• Hepatic regeneration in peroxisome proliferator-activated receptor α-null mice after partial hepatectomy
• Regulation of peroxisome proliferator activated receptor α-mediated pathways in alcohol fed cytochrome P450 2E1 deficient mice
• Metabolism of Selegiline Hydrochloride, a Selective Monoamine B-type Inhibitor, in Human Liver Microsomes
• γ-Adaptin Interacts Directly with Rabaptin-5 through Its Ear Domain
• OCCURRENCE OF AUTOANTIBODY TO PROTEIN DISULFIDE ISOMERASE IN PATIENTS WITH HEPATIC DISORDER
• OCCURRENCE OF AUTOANTIBODY TO PROTEIN DISULFIDE ISOMERASE IN RATS WITH XENOBIOTIC-INDUCED HEPATITIS
• Relevance of Irinotecan Hydrochloride-Induced Diarrhea to the Level of Prostaglandin E_2 and Water Absorption of Large Intestine in Rats
• MOLECULAR CLONING OF MOUSE LIVER FLAVIN CONTAINING MONOOXYGENASE (FMO1) cDNA AND CHARACTERIZATION OF THE EXPRESSION PRODUCT : METABOLISM OF THE NEUROTOXIN, 1,2,3,4- TETRAHYDROISOQUINOLINE (TIQ)
• HIGH SUSCEPTIBILITY TO AFLATOXIN B_1 AND BENZO[A]PYRENE OF BALB3T3 A31-1-1 CELLS EXPRESSING MONKEY CYP1A1
• LOW ACTIVITY OF ALDEHYDE DEHYDROGENASE (ALDH) IN LIVER OF SUNCUS MURlNUS : POSSIBLE EXPLANATION FOR HIGH SENSITIVITY TO ALCOHOL
• INHIBITION BY SKF 525-A OF 7-ETHOXYCOUMARIN O-DEETHYLATION IN MICROSOMAL AND THE RECONSTITUTED MONOOXYGENASE SYSTEMS FROM PCB-TREATED RAT LIVERS
• ADP-Ribosylation Factor-1 Is Sensitive to N-Ethylmaleimide
• A Major Genotype in UDP-glucuronosyltransferase 2B15
• Lung tumorigenesis promoted by anti-apoptotic effects of cotinine, a nicotine metabolite through activation of PI3K/Akt pathway

もっと見る 閉じる

スポンサーリンク