METABOLIC ACTIVATION OF AFLATOXIN B_1 BY HUMAN PLACENTAL MICROSOMES
スポンサーリンク
概要
- 論文の詳細を見る
The metabolic activation of aflatoxin B_1 by human placental microsomes was studied. Aflatoxin B_1 showed relatively high mutagenic activity in Ames test when incubated with human placental microsomes. Addition of α-naphthoflavone or aminoglutethimide, known inhibitors of cytochrome P450 1A and P450 19, respectively, into the test system partially inhibited the mutagen-producing activity. It was suggested that the activation of aflatoxin B_1 in human placental microsomes is mediated by at least these two forms of cytochrome P450.
- 日本トキシコロジー学会の論文
- 1993-05-25
著者
-
Kitamura Ryuji
Division Of Drug Metabolism Faculty Of Pharmaceutical Sciences Hokkaido University
-
Kitamura Ryuji
北海道大学 薬
-
KAMATAKI Tetsuya
Division of Drug Metabolism, Faculty of Pharmaceuti-cal Sciences, Hokkaido University
-
Kamataki T
Hokkaido Univ. Sapporo Jpn
-
Kamataki Tetsuya
Department Of Pharmacology School Of Medicine Keio University:department Of Analytical Biochemistry
-
SAWADA Minoru
Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Hokkaido University
-
NOROSE Takahiko
Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Hokkaido University
-
KITADA Mitsukazu
Hospital Pharmacy, Chiba University School of Medicine
-
ITAHASHI Koshiro
Kawasaki Seitetsu Hospital
-
Kamataki Tetsuya
Division Of Analytical Biochemistry Faculty Of Pharmaceutical Sciences Hokkaido University
-
Kitada Mitsukazu
Hospital Pharmacy Chiba University School Of Medicine
-
Sawada Minoru
Central Research Laboratories Zeria Pharmaceutical Co. Ltd.
-
Sawada Minoru
Division Of Drug Metabolism Faculty Of Pharmaceutical Sciences Hokkaido University
-
Komori Masayuki
Division Of Analytical Biochemistry Faculty Of Pharmaceutical Sciences Hokkaido University
-
Norose Takahiko
Division Of Drug Metabolism Faculty Of Pharmaceutical Sciences Hokkaido University
-
Kamataki Tetsuya
Lab. Drug Metab. Fac. Pharm. Sci. Hokkaido University
関連論文
- MACROMOLECULAR BINDING OF CARCINOGENIC/MUTAGENIC N- HYDROXYARYLAMINES THROUGH O-ACETYLATION PATHWAY
- MECHANISM OF MUTATION AND METABOLIC ACTIVATION OF NITRO-, NITROSO-, HYDROXYLAMINO-COMPOUNDS IN NITRO-COMPOUNDS RESISTANT MUTANTS OF AMES TESTAR STRAIN (TA98NR, TA98/1,8-DNP_6)
- Two Novel Single Nucleotide Polymorphisms (SNPs) of the FMO3 Gene in Japanese
- A Mutation in the Flavin-containing Monooxygenase 3 Gene and its Effects on Catalytic Activity for N-oxidation of Trimethylamine In Vitro
- Overexpression of CYP2A6 in human colorectal tumors
- O11-01 Induction of Human CYP1A1 by 2-Phenyl-benzotriazoles(PBTAs)which Are Metabolically Activated by CYP1A1
- O-18 Role of Human N-Acetyltransferase in the Metabolic Activation of 2-Phenylbenzotriazole (PBTA) Derivatives.(Proceedings of the 27th Annual Meeting)
- 21C-01-1 Metabolic Activation of PBTA-1 and PBTA-2 by Human Cytochrome P450 1A1.
- Safety assessment of biopharmaceuticals : Japanese perspective on ICH S6 guideline maintenance
- CURRENT OPINION : SAFETY EVALUATION OF DRUG METABOLITES IN DEVELOPMENT OF PHARMACEUTICALS
- Establishment of in silico systems to predict the effects of genetic polymorphism on the enzymatic activity of cytochrome P450
- ROLE OF GROWTH HORMONE ON THE EXPRESSION OF SEX-SPECIFIC FORMS OF CYTOCHROME P-450,P-450-MALE AND P-450-FEMALE
- STUDIES ON SEX-SPECIFIC FORMS OF CYTOCHROME P-450 IN MALE AND FEMALE RATS
- Inhibitory Effects of Nicardipine to Cytochrome P450 (CYP) in Human Liver Microsomes(Biopharmacy)
- Co-operative Regulation of the Transcription of Human Dihydrodiol Dehydrogenase(DD)4/Aldo-Keot Reductase(AKR)1C4 Gene by Hepatocyte Nuclear Factor(HNF)-4α/γand HNF-1α.
- Characterization of a Novel Variant (S145C/L311V) of 3α-Hydroxysteroid/Dihydrodiol Dehydrogenase in Human Liver.
- Expression and Characterization of Dog CYP2D15 Using Baculovirus Expression System^1
- CYP2A6 gene deletion reduces oral cancer risk in betel quid chewers.(GENERAL SESSION BY ORAL PRESENTATION)(DRUG METABOLISM)
- AHR-mediated suppression of PPARα target gene expression caused by exposed polycyclic aromatic hydrocarbons (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- 2B-08 Establishment of Genetically Engineered E.coli Highly Sensitive to Nitrosamines by Introducing Human CYP2E1
- CYP3A5 Contributes Significantly to CYP3A-mediated Drug Oxidations in Liver Microsomes from Japanese Subjects
- TOXICOLOGICAL SIGNIFICANCE OF A FORM OF CYTOCHROME P-450 HIGHLY PURIFIED FROM LIVER MICROSOMES OF PCBTREATED RATS : CATALYTIC AND IMMUNOCHEMICAL EXAMINATIONS OF A HIGH SPIN FORM OF CYTOCHROME P-448
- The Role of Glutathione in the Activation and Detoxication of a Naturally Occurring Mutagen-Carcinogen, Trp-P-2 (Regular Presentations) (Proceedings of the 10 th Symposium on Environmental Pollutants and Toxicology)
- MECHANISMS INVOLVED IN THE COVALENT BINDING OF A TRYPTOPHAN-PYROLYSATE PROMUTAGEN, TRP-P-2,TO DNA
- Metabolic activation of amino acid-pyrolysates and its relation to mutagenicity
- STUDIES ON CYTOCHROME P-450 RESPONSIBLE FOR THE OCCURRENCE OF SEX DIFFERENCE OF DRUG METABOLISM IN THE RAT
- A SENSITIVE METHOD FOR THE DETERMINATION OF BIPHENYL HYDROXYLASE ACTIVITY AND IT'S TOXICOLOGICAL APPLICATION
- MECHANISMS OF METABOLIC ACTIVATION OF A TRYPTOPHAN PYROLYSATE, 3-AMINO-1-METHYL-5H-PYRIDO [4,3-b] INDOLE
- PURIFICATION AND PROPERTIES OF CYTOCHROME P-450 AND NADPH-CYTOCHROME C (P-450) REDUCTASE FROM MICROSOMES OF HUMAN LIVERS
- STUDIES ON THE METABOLIC ACTIVATION AND THE MECHANISM OF TOXICITY OF DRUGS V. REDUCTION OF N-HYDROXY DERIVATIVE OF AN AROMATIC AMINE, 2-ACETYLAMINOFLUORENE BY CYTOCHROME P-450 (The 6th Meeting for the Study of Toxic Effect)
- DEGRADATION OF CYTOCHROME P-450 ASSOCIATED WITH METABOLIC ACTIVATION OF CARBON TETRACHLORIDE (The 5th Meeting for the Study of Toxic Effect)
- Application of Primary Hepatocytes from p53-Knockout Mice for Studies of Expression of Cyp3a
- Expression of human CYP1A2 capable of activating heterocyclic amine in Bm 6 cells using baculovirus (BmNPV) system.
- In vivo Evaluation of Coumarin and Nicotine as Probe Drugs to Predict the Metabolic Capacity of CYP2A6 Due to Genetic Polymorphism in Thais
- Novel Nonsynonymous Polymorphisms of the CYP1A1 Gene in Japanese
- Toxicological roles of human and rodent CYP2As in the mutagenic activation of N-nitrosamines.(GENERAL SESSION BY ORAL PRESENTATION)(DRUG METABOLISM)
- Novel Mutations of the CYP2A6 Gene in a Thai Population with Lowered Capacity of Coumarin 7-Hydroxylation
- O11-15 Mutagenic activation of tobacco-related N-nitrosamines by rat CYP2As in comparison with human CYP2A6.
- O11-14 Comparison of the toxicolqical roles of mouse CYP2A with human CYP2A6.
- Genetic Polymorphism in the 5'-Flanking Region of Human CYP1A2 Gene : Effect on the CYP1A2 Inducibility in Humans
- METABOLIC ACTIVATION OF AFLATOXIN B_1 BY HUMAN PLACENTAL MICROSOMES
- Formation of an Antibacterial Metabolite from a New Macrolide Compound 23-O-Benzyl-5-mycaminosyl-tylonolide (TMC-101), by a Hepatic Microsomal Drug-Metabolizing Enzyme System
- 5-2) MOLECULAR TOXICOLOGY ON CYTOCHROME P-450 IN HUMAN FETAL LIVERS
- Immunochemical Studies for the Presence of P-450 HFLa, a Form of Cytochrome P-450 in Human Fetal Livers in Human Hepatocellular Carcinoma Cells
- SPECIES DIFFERENCE OF CYTOCHROME (S) P-450 CROSS-REACTIVE WITH ANTI-P-450-MALE ANTIBODIES
- Large-scale Production of Genetically Engineered CYP3A4 in E. coli: Application of a Jarfermenter
- 21C-04-1 Inhibition of the Activity of Human Cytochrome P450 Involved in the Metabolic Activation of Procarcinogens by Green Tea Catechins.
- Establishment of Salmonella Tester Strains Co-expressing Cytochrome P450 and NADPH-cytochrome P450 Reductase.
- Application of Genetically Engineered Bacteria Carrying Human Cytochrome P450 to Toxicological Studies
- Metabolic Activation of Dimethylnitrosamine(DMN) by Human CYP2E1 Expressed in O^6-Methylguanine-DNA Methyltransferase-Deficient Cells
- Establishment Of A Salmonella Tester Strain Ultra-Sensitive To Mutagenic Heterocyclic Amines
- DEVELOPMENT OF PRACTICAL METHODS WHICH MIMIC DRUG METABOLISM IN HUMANS.
- EXPRESSION OF RECOMBINANT HUMAN CYTOCHROME P450 (P450 OR CYP) 2A6 IN ESCHERICHIA COLI.
- "S2-3 STRATEGIC PROPOSALS TO AVOID TOXIC DRUG INTERACTIONS DURING NEW DRUG DEVELOPMENT : MOLECULAR TOXICOLOGY PROPOSALS (Strategy how we can learn drug-drug interaction during the development of a new drug)
- Stable expression of CYP3A4 and CYP3A7, adult and fetal-specific forms of cytochrome P450 in human liver, in CHL cells and its application to toxicological testing.
- Effects of NO-1886 (Ibrolipim), a Lipoprotein Lipase-Promoting Agent, on Gene Induction of Cytochrome P450s, Carboxylesterases, and Sulfotransferases in Primary Cultures of Human Hepatocytes
- Detection of Three Genetic Polymorphisms in the 5'-Flanking Region and Intron 1 of Human CYP1A2 in the Japanese Population
- Homologous Unequal Cross-Over within the Human CYP2A Gene Cluster as a Mechanism for the Deletion of the Entire CYP2A6 Gene Associated with the Poor Metabolizer Phenotype
- 221 INTRODUCTION OF CYTOCHROME P-450 cDNAS INTO CULTURED MAMMALIAN CELLS AND THEIR APPLICATION TO IN VITRO TOXICOLOGICAL STUDIES
- Preventive Effects of Hange-shashin-to on Irinotecan Hydrochloride-Caused Diarrhea and Its Relevance to the Colonic Prostaglandin E_2 and Water Absorption in the Rat
- Protective Effects of Kampo Medicines and Baicalin against Intestinal Toxicity of a New Anticancer Camptothecin Derivative, Irinotecan Hydrochloride (CPT-11), in Rats
- W1-2 Toxicological Significance of Genetic Polymorphism of Cytochrome P450 : Genetic Polymorphism of CYP2A6 and Lung Cancer Risk.(Proceedings of the 27th Annual Meeting)
- 21C-01-2 Relationship Between Genetic Polymorphism of CYP2A6 and Lung Cancer Risk.
- Metabolism of Selegiline Hydrochloride, a Selective Monoamine B-type Inhibitor, in Human Liver Microsomes
- Operation at 700℃ of 6H-SiC UV Sensor Fabricated Using N^+ Implantation
- Reduction in Operating Current of High-Power 660nm Laser Diodes Using a Transparent AlGaAs Cap Layer
- Reduction in Operating Current of High-Power 660-nm Laser Diodes Using a Transparent AlGaAs Cap Layer
- OCCURRENCE OF AUTOANTIBODY TO PROTEIN DISULFIDE ISOMERASE IN PATIENTS WITH HEPATIC DISORDER
- OCCURRENCE OF AUTOANTIBODY TO PROTEIN DISULFIDE ISOMERASE IN RATS WITH XENOBIOTIC-INDUCED HEPATITIS
- Relevance of Irinotecan Hydrochloride-Induced Diarrhea to the Level of Prostaglandin E_2 and Water Absorption of Large Intestine in Rats
- MOLECULAR CLONING OF MOUSE LIVER FLAVIN CONTAINING MONOOXYGENASE (FMO1) cDNA AND CHARACTERIZATION OF THE EXPRESSION PRODUCT : METABOLISM OF THE NEUROTOXIN, 1,2,3,4- TETRAHYDROISOQUINOLINE (TIQ)
- P-97 Collaborative work to evaluate toxicity on male reproductive organs by repeated dose studies in rats. : 20)Effects of repeated doses of ethlnylestradlol for 2 and 4 weeks.(Proceedings of the 27th Annual Meeting)
- P-79 Influence of food restriction on hematology and urinalysis in Rats 2. : Comjparison of young rats and young-adult rats(Proceedings of the 27th Annual Meeting)
- COLLABORATIVE WORK TO EVALUATE TOXICITY ON MALE REPRODUCTIVE ORGANS BY REPEATED DOSE STUDIES IN RATS : 3)EFFECTS OF REPEATED DOSES OF ETHINYLESTRADIOL FOR 2 AND 4 WEEKS ON THE MALE REPRODUCTIVE ORGANS
- 21B-09-5 Influence of food restriction on hematology and urinalysis in Rats.
- HIGH SUSCEPTIBILITY TO AFLATOXIN B_1 AND BENZO[A]PYRENE OF BALB3T3 A31-1-1 CELLS EXPRESSING MONKEY CYP1A1
- LOW ACTIVITY OF ALDEHYDE DEHYDROGENASE (ALDH) IN LIVER OF SUNCUS MURlNUS : POSSIBLE EXPLANATION FOR HIGH SENSITIVITY TO ALCOHOL
- High-Power 660-nm-Band AlGaInP Laser Diodes with a Small Aspect Ratio for Beam Divergence
- Inhibition of UDP-glucuronosyltransferase by Aglycons of Natural Glucuronides in Kampo Medicines Using SN-38 as a Substrate
- INHIBITION BY SKF 525-A OF 7-ETHOXYCOUMARIN O-DEETHYLATION IN MICROSOMAL AND THE RECONSTITUTED MONOOXYGENASE SYSTEMS FROM PCB-TREATED RAT LIVERS
- O-17 Role of Human Cytochrome P450 in the Metabolic Activation of N-Alkylnitrosamines.(Proceedings of the 27th Annual Meeting)
- A Major Genotype in UDP-glucuronosyltransferase 2B15
- Lung tumorigenesis promoted by anti-apoptotic effects of cotinine, a nicotine metabolite through activation of PI3K/Akt pathway
- Interspecies homology of cytochrome P-450: Inhibition by anti-P-450-Male antibodies of testosterone hydroxylases in liver microsomes from various animal species including man.
- Immunochemical Evidence for the Occurrence of Mu Class Glutathione S-Transferase in Human Fetal Livers.