OCCURRENCE OF AUTOANTIBODY TO PROTEIN DISULFIDE ISOMERASE IN RATS WITH XENOBIOTIC-INDUCED HEPATITIS

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概要

• 論文の詳細を見る

• The occurrence of an autoantibody to protein disulfide isomerase (PDI) in rats after administration of various hepatotoxic drugs was investigated by immunoblotting and radioimmunoassay. An anti-PDI autoantibody was detected with high frequency in rats treated with D-galactosamine, acetaminophen with diethylmaleate, and carbon tetrachloride with diethylmaleate. The antibody-positive rate was relatively low in the groups of rats given carbon tetrachloride, acetaminophen or DL-ethionine alone. The anti-PDI antibody was not detected in rats treated with diethylmaleate alone. Although the mechanism of the production of the anti-PDI autoantibody is unclear, the occurrence of anti-PDI antibody correlated with high serum GPT activities. It is suggested that the autoantibody plays an important role in the development and persistence of drug-induced hepatitis.

• 日本トキシコロジー学会の論文
• 1994-08-25

著者

• KAMATAKI Tetsuya

  Division of Drug Metabolism, Faculty of Pharmaceuti-cal Sciences, Hokkaido University

• Kamataki T

  Hokkaido Univ. Sapporo Jpn

• Kamataki Tetsuya

  Department Of Pharmacology School Of Medicine Keio University:department Of Analytical Biochemistry

• YOKOI Tsuyoshi

  Division of Analytical Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University

• Nagayama Sekio

  Division Of Drug Metabolism Faculty Of Pharmaceutical Sciences Hokkaido University

• Kamataki Tetsuya

  Division Of Analytical Biochemistry Faculty Of Pharmaceutical Sciences Hokkaido University

• Yokoi T

  Laboratory Of Drug Metabolism Graduate School Of Pharmaceutical Sciences Hokkaido University

• Yokoi Tsuyoshi

  Division Of Analytical Biochemistry Faculty Of Pharmaceutical Sciences Hokkaido University:explorato

• KAWAGUCHI Yasuro

  Biological Research Laboratory, Taiho Pharmaceutical Co., Ltd.

• Kawaguchi Yasuro

  Biological Research Laboratory Taiho Pharmaceutical Co. Ltd.

• Kamataki Tetsuya

  Lab. Drug Metab. Fac. Pharm. Sci. Hokkaido University

• YOKOI Tsuyoshi

  Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Hokkaido University

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