HIGH SUSCEPTIBILITY TO AFLATOXIN B_1 AND BENZO[A]PYRENE OF BALB3T3 A31-1-1 CELLS EXPRESSING MONKEY CYP1A1

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概要

• 論文の詳細を見る

• The monkey CYP1A1 has been expressed in BALB 3T3 A31-1-1 cells and the expressed proteins were assayed for their capacity to activate aflatoxin B_1(AFB_1) and benzo[a]pyrene (B[a]P). The transformed cells were approximately 5.4-and 4/7-fold more sensitive to AFB_1 and B[a]P than the parental cells, respectively. These results indicate that monkey CYPlA1 cDNA encoded a functional protein and that the expressed CYPlAl enzyme is active for the activation of B[a]P as well as AFB_1 to produce toxic metabolites.

• 日本トキシコロジー学会の論文
• 1993-08-25

著者

• ITOH Susumu

  Division of Drug Metabolism, Faculty of Pharmaceuti-cal Sciences, Hokkaido University

• KAMATAKI Tetsuya

  Division of Drug Metabolism, Faculty of Pharmaceuti-cal Sciences, Hokkaido University

• Kamataki T

  Hokkaido Univ. Sapporo Jpn

• Kamataki Tetsuya

  Department Of Pharmacology School Of Medicine Keio University:department Of Analytical Biochemistry

• ITOH Shinji

  Hokkaido College of Pharmacy

• Kamataki Tetsuya

  Division Of Analytical Biochemistry Faculty Of Pharmaceutical Sciences Hokkaido University

• Itoh Susumu

  Division Of Drug Metabolism Faculty Of Pharmaceutical Sciences Hokkaido University

• Sawada Minoru

  Central Research Laboratories Zeria Pharmaceutical Co. Ltd.

• TAGAWA Sanae

  Division of Drug Metabolism, Faculty of Pharmaceutical Sciences, Hokkaido University

• SAWADA Minoru

  Hokkaido Institute of Pharmaceutical Sciences

• Itoh S

  Hokkaido College Of Pharmacy

• Itoh Susumu

  Division Of Cellular Physiology Faculty Of Pharmaceutical Sciences Osaka University

• Tagawa Sanae

  Division Of Drug Metabolism Faculty Of Pharmaceutical Sciences Hokkaido University

• Kamataki Tetsuya

  Lab. Drug Metab. Fac. Pharm. Sci. Hokkaido University

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