Evidence of Direct Conversion of Testosterone Sulfate to Estradiol 17-Sulfate by Human Placental Microsomes
スポンサーリンク
概要
- 論文の詳細を見る
Ring A aromatization of testosterone sulfate (TS), using human term placental microsomes as a enzyme source, was examined under a reduced nicotinamide adenine dinucleotide phosphate (NADPH)-generating system. The aromatization to estradiol 17-sulfate (ES) without removal of the C-17 conjugate group was confirmed. Judging from the results of various experiments, including an inhibition experiment, the conversion was considered to occur by placental aromatase. Apparent K_m and V_<max> values for this aromatization were determined to be 37.4 μM and 330 pmol/mg protein/min respectively. The physiological role of direct conversion of TS by placenta to ES is discussed in connection with pregnancy.
- 公益社団法人日本薬学会の論文
著者
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伊藤 慎二
北海道薬科大学
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伊藤 慎二
Hokkaido College Of Pharmacy
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WATANABE Kazuhiro
Hokkaido Pharmaceutical University, School of Pharmacy
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TAKANASHI Kaori
Hokkaido College of Pharmacy
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ITOH Shinji
Hokkaido College of Pharmacy
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YOSHIZAWA Itsuo
Hokkaido College of Pharmacy
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SATOH Takashi
Hokkaido College of Pharmacy
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ITOH Yoshimi
Hokkaido College of Pharmacy
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TAKAGI Hidetoshi
Hokkaido College of Pharmacy
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Kashiwagi Tomohiro
Department Of Obstetrics And Gynecology Kyoto Prefectural University Of Medicine
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Watanabe K
New Drug Research Department High Quality-life Research Laboratories Bio-medical Division
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Satoh T
Tokyo Univ. Sci. Tokyo Jpn
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Yoshizawa I
Hokkaido College Of Pharmacy
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Satoh Takashi
Yakuhan Pharmaceutical Co. Ltd.
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Watanabe Kazuhiro
Hokkaido Institute Of Pharmaceutical Science
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