Actions of the Novel Oral Antidiabetic Agent HQL-975 in Genetically Obese Diabetic db/db Mice
スポンサーリンク
概要
- 論文の詳細を見る
The hypoglycemic effect of the novel oral agent 3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxyl]-phenyl}-2S-propylamino-propionic acid (HQL-975) was examined in db/db mice with genetically obese non-insulin dependent diabetes mellitus (NIDDM). The oral administration of HQL-975 at 3.5 and 35.3 mg/kg/d for 7 d decreased the plasma glucose level of these mice in a dose-dependent manner. HQL-975 also significantly decreased the plasma triglyceride, total cholesterol, non-esterified fatty acid and insulin levels. In the oral glucose tolerance test, HQL-975-treated mice showed improved glucose tolerance and decreased endogenous insulin secretion. HQL-975 increased glycemic response to exogenous insulin in the mice. In the HQL-975-treated db/db mice adipocytes, the glucose uptake, insulin binding, and GLUT4 expression were increased compared with those in untreated db/db mice adipocytes. These results indicate that HQL-975 improved insulin action in db/db mice through receptor and post-receptor effects.In conclusion, HQL-975 is a new oral antidiabetic agent with a hypoglycemic effect which is associated with an insulin-sensitizing effect. This agent may therefor be effective for the treatment of NIDDM.
- 公益社団法人日本薬学会の論文
- 1998-09-15
著者
-
Tani T
Institute Of Natural Medicine University Of Toyama:21st Century Coe Program University Of Toyama
-
Tani T
New Drug Research Department High Quality-life Research Laboratories Bio-medical Division
-
Tani Tadato
New Drug Research Department High Quality-life Research Laboratories Bio-medical Division
-
Watanabe K
New Drug Research Department High Quality-life Research Laboratories Bio-medical Division
-
ISHIKAWA Yuji
New Drug Research Department High Quality-Life Research Laboratories, Bio-Medical Division
-
TAKENO Hidekazu
New Drug Research Department High Quality-Life Research Laboratories, Bio-Medical Division
-
WATANABE Kazuhiro
New Drug Research Department High Quality-Life Research Laboratories, Bio-Medical Division
-
TAKAGI Yoko
New Drug Research Department, High Quality-Life Research Laboratories, Bio-Medical Division, Sumitom
-
Takagi Y
New Drug Research Department High Quality-life Research Laboratories Bio-medical Division Sumitomo M
-
Ishikawa Y
Graduate School Of Pharmaceutical Sciences Kumamoto University
-
Ishikawa Y
Nara Women's Univ. Nara Jpn
-
Takeno H
New Drug Research Department High Quality-life Research Laboratories Bio-medical Division
関連論文
- Evaluation of Variation of Acteoside and Three Major Flavonoids in Wild and Cultivated Scutellaria baicalensis Roots by Micellar Electrokinetic Chromatography
- 富山オリジナルブランド配置薬の生活習慣病モデル動物に対する効果
- Pyrrole Butyric Acid Derivatives as Inhibitors of Steroid 5α-Reductase
- 飲食失節と飲食労倦による内傷に用いる生薬
- 『脾胃論』における生薬の用法と『内外傷弁惑論』との関連
- 『内外傷弁惑論』における内傷治療の用薬規範
- 『傷寒論』の病期別の薬対から用薬規範を探る
- 炙甘草を中心にした薬対から『傷寒論』処方の構成を探る
- 処方と生薬の使用頻度から『金匱要略』の用薬規範を探る
- 処方と生薬の使用頻度から『傷寒論』の用薬規範を探る
- P-99 生薬の使用頻度から『弁惑論』の特徴を探る
- Evidence of Direct Conversion of Testosterone Sulfate to Estradiol 17-Sulfate by Human Placental Microsomes
- Bofutsushosan, a Traditional Chinese Formulation, Prevents Intimal Thickening and Vascular Smooth Muscle Cell Proliferation Induced by Balloon Endothelial Denudation in Rats(Pharmacognosy)
- Saiko-ka-Ryukotsu-Borei-To Inhibits Intimal Thickening in Carotid Artery after Balloon Endothelial Denudation in Cholesterol-fed Rats(Pharmacognosy)
- Effects of oral administrations of some traditional Chinese formulations on smooth muscle cells proliferation in rat artery after balloon catheter denudation
- Effects of Chronic Administration of Bopindolol on the Binding Characteristics of Cardiac α_-, α_-, β_1- and β_2-Adrenoceptor Subtypes in Cardiac Muscles of Spontaneously Hypertensive Rats (SHR)
- Pharmacological Studies on the Novel Antiallergic Drug HQL-79 : II. Elucidation of Mechanisms for Antiallergic and Antiasthmatic Effects
- Pharmacological Studies on the Novel Antiallergic Drug HQL-79 : I. Antiallergic and Antiasthmatic Effects in Various Experimental Models
- Isoliquiritigenin, One of the Antispasmodic Principles of Glycyrrhiza Ularensis Roots, Acts in the Lower Part of Intestine(Pharmacognosy)
- Restorative Effect of Repetitive Administration of Shaoyao-Gancao-tang on Bioavailability of Paeoniflorin Reduced by Antibacterial Synthetic Drugs Treatment in Rats(Pharmacognosy)
- Development of a Simple HPLC Method for Determination of Paeoniflorin-Metabolizing Activity of Intestinal Bacteria in Rat Feces
- The Influence of Commonly Prescribed Synthetic Drugs for Peptic Ulcer on the Pharmacokinetic Fate of Glycyrrhizin from Shaoyao-Gancao-tang
- Lipogenic Action of the Novel Oral Antidiabetic Agent HQL-975 in Genetically Obese Diabetic KK-Ay Mice
- Actions of the Novel Oral Antidiabetic Agent HQL-975 in Genetically Obese Diabetic db/db Mice
- Indole Alkaloid Production in Callus Cultures of Uncaria rhynchophylla (MIQ.) MiQUEL
- Pharmaceutical Evaluation of Cultivated Glycyrrhiza uralensis Roots in Comparison of Their Antispasmodic Activity and Glycycoumarin Contents with Those of Licorice(Pharmacognosy)
- Affinity for [^3H]Iloprost Binding Sites and cAMP Synthesis Activityof a 3-Oxa-methano Prostaglandin I_1Analog, SM-10906,in Human Platelets and Endothelial Cells
- Slow Dissociation of Long-Acting Ca^ Antagonist Amlodipine from ^3H-PN200-110 Binding Sites in Membranes of Rat Hearts and Brains
- TISSUE DISTRIBUTION OF ESTRADIOL 17-SULFATE 2- AND 4-HYDROXYLATION ENZYMES IN THE RAT
- STUDIES ON THE METABOLISM OF CONJUGATED CATECHOL ESTROGENS IN RATS
- 1P169 Over-expression of Recombinant Human Hemoglobin(5. Heme protein,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
- 1P163 Roles of Cysteine Residues in the Gas Binding to Human Neuroglobin(5. Heme protein,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
- 1P162 Exogenous Ligand Binding Mechanism of Cytoglobin(5. Heme protein,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
- 1P161 Substrate Binding and Metabolizing Properties of Indoleamine 2,3-Dioxygenase(5. Heme protein,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
- 1P154 Resonance Raman Studies of CYP2C19 and Its Complexes with Substrates(5. Heme protein,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
- Self-Aggregation Inhibits the Photonuclease Activity of Porphyrins
- Solution Properties and Photonuclease Activity of Cationic Bis-porphyrins Linked with a Series of Aliphatic Diamines
- Bioavailability and Diuretic Effect after Administration of Retarded Capsules of Bumetanide in Human Subjects
- Preparation of Sustained Release Granules of Bumetanide
- Cryopreservation of Medaka Spermatozoa
- 富山県の産官学連携研究で開発された新しい配置薬
- 言葉の限界と有用性
- Inhibitory effects of a newly devised crude drug-preparation on intimal thickening after endothelial injury in rats
- 新たに創案された富山オリジナルブランド配置薬処方の活性酸素種消去活性および神経細胞保護作用の検討