Restorative Effect of Repetitive Administration of Shaoyao-Gancao-tang on Bioavailability of Paeoniflorin Reduced by Antibacterial Synthetic Drugs Treatment in Rats(Pharmacognosy)
スポンサーリンク
概要
- 論文の詳細を見る
Paeoniflorin (PF) is an active glucoside in Shaoyao (peony root), and is transformed into an antispasmodic metabolite, paeonimetabolin-I (PM-I), by intestinal bacteria in the gut after oral administration of Shaoyao or Shaoyao-Gancao-tang (SGT, Shakuyaku-Kanzo-To in Japanese). SGT is a pain-relieving traditional Chinese formulation (Kampo-medicine in Japanese) and is often used together with antibacterial synthetic drugs, such as amoxicillin and metronidazole (AMPC-MET), in peptic ulcer therapy. Since the bioavailability of PF in SGT has been reported to be significantly reduced by co-administered antibacterial drugs, we investigated how to minimize this reducing effect of antibacterial treatment in the present study. We found that repetitive administration of SGT starting 24 h after AMPC-MET treatment rapidly restored the plasma PM-I concentration from SGT reduced by AMPC-MET, due to its restorative effect on the decreased PF-metabolizing activity of intestinal bacteria in rat feces. The present findings suggest that it may be clinically useful to administer SGT repetitively, starting 1 or 2 d after treatment with a mixture of AMPC-MET during their combination therapy, to accelerate the recovery of the reduced bioavailability of PF in SGT. Similar administration regimens may also be useful in other combination therapies involving traditional Chinese formulations and antibacterial synthetic drugs to ensure the efficacy of the bioactive glycosides in the formulations.
- 公益社団法人日本薬学会の論文
- 2003-11-01
著者
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AKAO Teruaki
Faculty of Pharmaceutical Sciences, University of Toyama
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Tani T
Institute Of Natural Medicine University Of Toyama:21st Century Coe Program University Of Toyama
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Tani T
New Drug Research Department High Quality-life Research Laboratories Bio-medical Division
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Akao Teruaki
Faculty Of Pharmaceutical Sciences University Of Toyama
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Akao Teruaki
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Akao Teruaki
Graduate School Of Medicine And Pharmaceutical Sciences Univ. Of Toyama
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Akao Teruaki
Department Of Enzymatic Physiology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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TANI Tadato
Institute of Natural Medicine, University of Toyama
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Tani Tadato
Institute Of Natural Medicine University Of Toyama:21st Century Coe Program University Of Toyama
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He Ju-xiu
Institute Of Natural Medicine University Of Toyama
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〓 忠人
富山医科薬科大学和漢薬研究所和漢薬製剤開発部門:富山医科薬科大学21世紀coeプログラム
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Tani Tadato
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Akao Teruaki
Institute Of Natural Medicine Toyama Medical
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He Jun-Xiu
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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