Pyrrole Butyric Acid Derivatives as Inhibitors of Steroid 5α-Reductase
スポンサーリンク
概要
- 論文の詳細を見る
A series of pyrrole butyric acid derivatives was synthesized and evaluated for inhibitory activity on human and rat steroid 5α-reductase in vitro and ex vivo. 3-Benzoyl-4-alkylpyrrole-1-butyric acids and 1-methyl-2-alkyl-3-benzoylpyrrole-5-butyric acid derivatives were effective inhibitors. Structure activity relationships were evaluated among the 37 compounds synthesized. Compound 37 (HQL-1069) shows potent inhibitory activities against both rat and human 5α-reductase.
- 公益社団法人日本薬学会の論文
- 1997-11-15
著者
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Sakai Yusuke
Faculty Of Pharmaceutical Sciences Kumamoto University
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Sakai Y
Gifu Prefectural Inst. Health And Environmental Sci. Gifu Jpn
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Kato M
Ishihara Sangyo Kaisha Ltd. Shiga Jpn
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Tani T
Sumitomo Metal Ind. Kyoto Jpn
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Tani Tadato
New Drug Research Department High Quality-life Research Laboratories Bio-medical Division
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KATO Masaya
Medical Chemistry Laboratory Sumitomo Metal Industries, Ltd.,
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KOMODA Keiko
Medical Chemistry Laboratory Sumitomo Metal Industries, Ltd.,
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NAMERA Akira
Medical Chemistry Laboratory Sumitomo Metal Industries, Ltd.,
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SAKAI Yusuke
Medical Chemistry Laboratory Sumitomo Metal Industries, Ltd.,
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OKADA Satoshi
Medical Chemistry Laboratory Sumitomo Metal Industries, Ltd.,
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YAMADA Akira
Pharmaceutical Laboratory, Sumitomo Metal Industries, Ltd.,
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YOKOYAMA Kouichi
Pharmaceutical Laboratory, Sumitomo Metal Industries, Ltd.,
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MIGITA Emiko
Pharmaceutical Laboratory, Sumitomo Metal Industries, Ltd.,
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MINOBE Yasushi
Pharmaceutical Laboratory, Sumitomo Metal Industries, Ltd.,
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Sakai Yusuke
Medical Chemistry Laboratory Sumitomo Metal Industries Ltd.
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Kato Masaya
Medical Chemistry Laboratory Sumitomo Metal Industries Ltd.
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Migita Emiko
Pharmaceutical Laboratory Sumitomo Metal Industries Ltd.
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Komoda Keiko
Medical Chemistry Laboratory Sumitomo Metal Industries Ltd.
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Namera A
Department Of Legal Medicine Graduate School Of Biomedical Sciences Hiroshima University
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Minobe Yasushi
Pharmaceutical Laboratory Sumitomo Metal Industries Ltd.
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Yokoyama Kouichi
Pharmaceutical Laboratory Sumitomo Metal Industries Ltd.
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Okada Satoshi
Medical Chemistry Laboratory Sumitomo Metal Industries Ltd.
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Yamada Akira
Pharmaceutical Laboratory Sumitomo Metal Industries Ltd.
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