Preparation of Sustained Release Granules of Bumetanide
スポンサーリンク
概要
- 論文の詳細を見る
Sustained release granules of bumetanide (BN) were prepared to obtain mild and sustained diuresis. BN was dispersed in combined matrixes of ethylcellulose (EC) with hydroxypropylmethylcellulose phthalate (HPMCP), povidone (PVP) or cyclodextrins (CDs). Release of BN from these preparations was evaluated by the JP XIII dissolution test in JP disintegration media No. 1 (pH 1.2) and No. 2 (pH 6.8) at 37℃. The interaction of BN with CDs in buffer solutions with different pHs was also investigated, and BN from the preparation with the component of BN : γ-CD : EC=1 : 4 : 2 (weight ratio) showed the most favorable sustained release pattern. The apparent stability constant of the γ-CD system on the BN solubility was greater than those of the α- or β-CD systems. Crystalline BN was not observed in this system in studies using powder X-ray diffraction spectra and a differential scanning calorimeter.
- 公益社団法人日本薬学会の論文
- 1997-05-15
著者
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TAKADA Masahiko
Faculty of Phartmaceutical Sciencses, Health Sciences University of Hokkaido
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Takahashi Masashi
Dep. Of Radiology Shiga Univ. Of Medical Sci.
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SEKIKAWA HITOSHI
Faculty of Pharmaceutical Sciences, Hokkaido University
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Takada Masahiko
Department Of Physiology School Of Dentistry At Tokyo Nippon Dental University
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Ishikawa Y
Graduate School Of Pharmaceutical Sciences Kumamoto University
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YAGI Naomi
Faculty of Pharmaceutical Scicences, Health Sciences University of Hokkaido
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KIUCHI Takashi
Faculty of Pharmaceutical Scicences, Health Sciences University of Hokkaido
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SATOH Hayato
Faculty of Pharmaceutical Scicences, Health Sciences University of Hokkaido
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ISHIKAWA Yohko
Faculty of Pharmaceutical Scicences, Health Sciences University of Hokkaido
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Takada Masahiko
Faculty Of Pharmaceutical Scicences Health Sciences University Of Hokkaido:(present Address)sapporo
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Takada Masahiko
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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Satoh H
Faculty Of Pharmaceutical Sciences Hokuriku University
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Kiuchi Takashi
Faculty Of Pharmaceutical Scicences Health Sciences University Of Hokkaido
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Yagi Naomi
Faculty Of Pharmaceutical Scicences Health Sciences University Of Hokkaido
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Sekikawa Hitoshi
Faculty Of Pharmaceutical Scicences Health Sciences University Of Hokkaido
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Yagi Naomi
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Takahashi Masashi
Department Of Radiology Shiga University Of Medical Science
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