Dissolution Behavior of Probucol from Solid Dispersion Systems of Probucol-Polyvinylpyrrolidone
スポンサーリンク
概要
- 論文の詳細を見る
Solid dispersion systems of probucol-polyvinylpyrrolidone (PVP) K25,K30 and K90 were prepared in various weight ratios by co-evaporation of the drug and PVP ethanolic solution. The observation of solid dispersion systems by powder X-ray diffraction spectra and differential scanning calorimeter indicated that probucol in the systems did not exhibit its crystalline property. The solubility of probucol in water at 25℃ was 5 ng/ml at most, and its dissolution was markedly increased in the solid dispersion systems in the JP XII disintegration media No. 1 (pH 1.2) and No. 2 (pH 6.8) at 37℃. Probucol concentrations after the dissolution of the solid dispersion systems showed hypersaturation. The solid dispersion system of 1 : 9 (probucol : PVP K 30 in weight ratio) showed the best dissolution of probucol among the systems prepared in the study.
- 公益社団法人日本薬学会の論文
- 1996-01-15
著者
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Takahashi Masashi
Dep. Of Radiology Shiga Univ. Of Medical Sci.
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Takada Masahiko
Department Of Physiology School Of Dentistry At Tokyo Nippon Dental University
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YAGI Naomi
Faculty of Pharmaceutical Scicences, Health Sciences University of Hokkaido
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Takada Masahiko
Faculty Of Pharmaceutical Scicences Health Sciences University Of Hokkaido:(present Address)sapporo
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Takada Masahiko
Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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Yagi Naomi
Faculty Of Pharmaceutical Scicences Health Sciences University Of Hokkaido
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KENMOTSU Harumi
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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Sekikawa Hitoshi
Faculty Of Pharmaceutical Scicences Health Sciences University Of Hokkaido
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Yagi Naomi
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Kenmochi H
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Terashima Yuhji
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Kenmotsu Harumi
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Takahashi Masashi
Department Of Radiology Shiga University Of Medical Science
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