Effect of Pulsed Output Ultrasound on the Transdermal Absorption of Indomethacin from an Ointment in Rats
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概要
- 論文の詳細を見る
The effect of pulsed output ultrasound (1 MHz) with on/off ratios of 1 : 2,1 : 4 and 1 : 9 on transdermal absorption of indomethacin from an ointment was studied in rats. Ultrasound energy was supplied for between 10 and 19 min at a range of intensities (1.0-2.5 W・cm^<-2>), energy levels commonly used for therapeutic purposes. The on/off pulsed ratio, intensity and the time of application were found to play an important role in the transdermal phonophoretic delivery system of indomethacin; 1 : 2 pulsed output ultrasound appeared to be the most effective in improving the transdermal absorption. The highest penetration was observed at an intensity of 1.0 W・cm^<-2> and application time of 15 min. With pulsed output it was possible to use higher intensities of ultrasound without increasing skin temperature or damaging skin.
- 公益社団法人日本薬学会の論文
- 1997-03-15
著者
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TAKADA Masahiko
Faculty of Phartmaceutical Sciencses, Health Sciences University of Hokkaido
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Asano Junji
Faculty Of Pharmaceutical Sciences Health Science University Of Hokkaido
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MIYAZAKI Shozo
Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido
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Takada Masahiko
Faculty Of Pharmaceutical Scicences Health Sciences University Of Hokkaido:(present Address)sapporo
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Miyazaki S
Faculty Of Pharmaceutical Sciences Health Science University Of Hokkaido
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SUISHA Fumie
Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido
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KAWASAKI Naoko
Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido
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Suisha Fumie
Faculty Of Pharmaceutical Sciences Health Science University Of Hokkaido
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Kawasaki Naoko
Faculty Of Pharmaceutical Sciences Health Science University Of Hokkaido
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Takada Masahiko
Faculty Of Pharmaceutical Sciences Health Science University Of Hokkaido
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