Carrageenan Gels for Oral Sustained Delivery of Acetaminophen to Dysphagic Patients
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概要
- 論文の詳細を見る
We have designed gel formulations for the oral administration of acetaminophen with suitable rheological characteristics for ease of administration to patients with swallowing difficulties and sufficient integrity in the stomach to achieve a sustained release of this drug. Gels formed by agar and ι-carrageenan were assessed for suitable gel strength and in vitro and in vivo release characteristics. Comparison of 1.5% ι-carrageenan gel with 0.5% agar gel demonstrated improved sustained release properties of the ι-carrageenan gel. Gel formed by ι-carrageenan has suitable rheological and sustained release characteristics for potential use as vehicles for oral delivery of drugs to dysphagic patients.
著者
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Attwood David
School Of Pharmacy And Pharmaceutical Sciences University Of Manchester
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Itoh Kunihiko
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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MIYAZAKI Shozo
Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido
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Shimoyama Tetsuya
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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Ishitani Mariko
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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Takahashi Akie
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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