Application of Spontaneous Schiff Base Copper Chelates Formation Process to the Design of a Trypsin Inhibitor
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概要
- 論文の詳細を見る
Salicylaldehyde derivatives carrying an amidinium group react spontaneously with α-amino acids in copper-containing aqueous media to afford very stable Schiff base copper chelates. A variety of Schiff base chelates were prepared from various α-amino acids. Each α-amino acid provides enantiomeric isomers due to the asymmetric α-carbon, except for glycine. Inhibitory activity of these amidinium chelates toward trypsin was generally very strong. Thus these compounds represent a novel series of potent trypsin inhibitors. The structure-activity relationship of the inhibitors is discussed based on their inhibition constants, though the variations are not large.
- 1996-05-15
著者
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Toyota Eiko
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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Sekizaki Haruo
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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Toyota E
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Toyota Eiko
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Itoh Kunihiko
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Sekizaki H
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Sekizaki Haruo
Faculty Of Pharmaceutical Sciences Health Science University Of Hokkaido
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TANIZAWA Kazutaka
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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CHINEN Chisako
Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido
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Chinen Chisako
Faculty Of Pharmaceutical Sciences Health Science University Of Hokkaido
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Tanizawa K
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Chinen Chisako
Faculty Of Pharmaceutical Science Health Sciences University Of Hokkaido
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Sekizaki Haruo
Faculty of Pharmaceutical Science, Higashi Nippon Gakuen University
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Toyota Eiko
Faculty of Pharmaceutical Science, Higashi Nippon Gakuen University
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