Synthesis and Properties of N^α-(tert-Butyloxycarbonyl)peptide p-Guanidinophenyl Esters as Trypsin Substrates
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概要
- 論文の詳細を見る
N^α-(tert-Butyloxycarbonyl)peptide p-guanidinophenyl esters were synthesized by amidination of N^α-(tert-butyloxycarbonyl)peptide p-aminophenyl esters with 1-[N, N'-bis(benzyloxycarbonyl)amidino]pyrazole, followed by deprotection by catalytic hydrogenation, in good total yields. These synthetic esters were characterized as specific substrates for trypsin, and kinetic parameters for the trypsin-catalyzed hydrolysis are presented.
- 公益社団法人日本薬学会の論文
- 1995-12-15
著者
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伊藤 邦彦
Faculty of Pharmaceutical Sciences, Hokkaido University
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関崎 春雄
Faculty of Pharmaceutical Sciences, Health Science University
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谷澤 和隆
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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豊田 栄子
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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豊田 栄子
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Toyota E
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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伊藤 邦彦
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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関崎 春雄
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Sekizaki Haruo
Faculty Of Pharmaceutical Sciences Health Science University Of Hokkaido
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