Synthesis and Triptic Hydrolysis of p-Guanidinophenyl Esters Derived from Amino Acids and Peptides
スポンサーリンク
概要
- 論文の詳細を見る
A facile synthetic method for p-guanidinophenyl esters derived from a variety of amino acids and peptides, including D-amino acids, is presented. The kinetic behavior of trypsin towards these synthetic esters, inverse substrates, was analyzed. The spatial requirement of the enzyme active site for catalytic efficiency is discussed based on the steric characteristics of the substrates.
- 1996-08-15
著者
-
Toyota Eiko
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
-
Sekizaki Haruo
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
-
Toyota E
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
-
Toyota Eiko
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
-
Itoh Kunihiko
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
-
Sekizaki H
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
-
Sekizaki Haruo
Faculty Of Pharmaceutical Sciences Health Science University Of Hokkaido
-
TANIZAWA Kazutaka
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
-
Tanizawa K
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
-
Sekizaki Haruo
Faculty of Pharmaceutical Science, Higashi Nippon Gakuen University
-
Toyota Eiko
Faculty of Pharmaceutical Science, Higashi Nippon Gakuen University
関連論文
- Atlantic Cod Trypsin-Catalyzed Peptide Synthesis with Inverse Substrates as Acyl Donor Components
- In vitro proliferation and triterpenoid characteristics of licorice (Glycyrrhiza uralensis Fischer, Leguminosae) stolons
- In vitro proliferation and triterpenoid characteristics of licorice (Glycyrrhiza uralensis Fischer, Leguminosae) stolons
- 2P034 Crystal structure of Atlantic cod trypsin(29. Protein structure and dynamics (II),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
- Trypsin-Catalyzed Synthesis of Dipeptide Containing α-Aminoisobutylic Acid Using p- and m-(Amidinomethyl)phenyl Esters as Acyl Donor
- A Facile Synthesis of p- and m-(Amidinomethyl)phenyl Esters Derived from Amino Acid and Tryptic Hydrolysis of These Synthetic Inverse Substrates
- Kinetic Properties of Three Isoforms of Trypsin Isolated from the Pyloric Caeca of Chum Salmon (Oncorhynchus keta)(Analytical Biochemistry)
- Amidino-Containing Schiff Base Copper(II) and Iron(III) Chelates as a Thrombin Inhibitor
- Synthesis and Evaluation of Guanidine-Containing Schiff Base Copper(II), Zinc(II), and Iron(III) Chelates as Trypsin Inhibitors
- Application of Various Inverse Substrates to Thrombin-Catalyzed Peptide Synthesis
- Application of Schiff Base Copper(II) and Iron(III) Chelates to Site-Specific Cleavage of a Trypsin
- The Structural Requirements for an Inverse Substrate for Enzymatic Peptide Synthesis : Position Isomers of Guanidinonaphthyl Esters as the Acyl Donor Component
- Enzymatic Peptide Synthesis with p-Guanidinophenyl and p-(Guanidinomethyl)phenyl Esters as Acyl Donors
- Tripsin-Catalyzed Peptide Synthesis with Various p-Guanidinophenyl Esters as Acyl Donors
- Synthesis and Triptic Hydrolysis of p-Guanidinophenyl Esters Derived from Amino Acids and Peptides
- Application of Spontaneous Schiff Base Copper Chelates Formation Process to the Design of a Trypsin Inhibitor
- Identification of Armillaria nabsnona in Gastrodia Tubers(Pharmacognosy)
- Cultivation and preparation of Lithospermum roots quantification of total pigment in slender lateral roots
- Solid-State Interaction of Ibuprofen with Polyvinylpyrrolidone
- Synthesis and Properties of N^α-(tert-Butyloxycarbonyl)peptide p-Guanidinophenyl Esters as Trypsin Substrates
- The Influence of Gastric Acidity and Taste Masking Agent on In Situ Gelling Pectin Formulations for Oral Sustained Delivery of Acetaminophen(Biopharmacy)
- ISOLATION OF TETRAAMMINE (SALICYLIDENEIMINATO) COBALT (III) CHLORIDE HYDRATE
- Isolation of β_1- and β_2-(8-Quinolinolato) (triethylene-tetramine) cobalt (III) Complexes
- β_1 and β_2-Isomers of Salicylato (triethylenetetramine) cobalt (III) Complex
- A Facile Synthesis of Benzofuran Derivatives: A Useful Synthon for Preparation of Trypsin Inhibitor
- BEHAVIOR OF TRYPSIN AND RELATED ENZYMES TOWARD AMIDINOPHENYL ESTERS
- NEW CHROMOGENIC AND FLUOROGENIC SUBSTRATES FOR THE DETERMINATION OF BUTYRYLCHOLINESTERASE AND ARYLESTERASE ACTIVITIES
- "INVERSE SUBSTRATES" FOR TRYPSIN-LIKE ENZYMES
- Cobalt(III) Complexes with [N_6-nX_n]-Type Ligands. VIII. Perparation and Properties of Iaomers of the (Salicylaldoximato)(triethylenetetramine)cobalt(III) Complexes and Crystal Structure of cis-β_1-(RS, SR)-[Co(salal)(trien)]Cl・(CH_3COCH_3)・2H_2O
- Identification of a Novel Carbohydrate-Mimicking Octapeptide from Chemical Peptide Library and Characterization as Selectin Inhibitor
- Effect of D-Sorbitol on the Thermal Gelation of Methylcellulose Formulations for Drug Delivery
- Variation of Glycyrrhizin and Liquiritin Contents within a Population of 5-Year-Old Licorice (Glycyrrhiza uralensis) Plants Cultivated under the Same Conditions
- Carrageenan Gels for Oral Sustained Delivery of Acetaminophen to Dysphagic Patients
- Cobalt(III) complexes with quadridentate ligands. VIII. The preparation and properties of cis-.BETA.1 and .BETA.2-isomers of the thiosalicylato(quadridentate amine)cobalt(III) complexes.
- Cobalt(III) complexes with quadridentate ligands. IX. High-resolution solid-state 13C CP/MAS NMR spectra of the salicylato-, carbonato-, dichloro-, and dinitro(quadridentate amine)-cobalt(III) complexes.
- Preparation and properties of ".BETA.1 and .BETA.2"-isomers of the salicylato(triethylenetetramine)cobalt(III) complex.
- Paramagnetic cobalt(III) complexes with organic ligands V. The isolation and properties of salts of the paramagnetic bis(2,2'-bipyridine)(5-nitrosalicylato)cobalt(III) and of the paramagnetic ".BETA.1 and .BETA.2"-isomers of the 5-nitrosalicylato(triethyl
- Cobalt(III) complexes with (N6-nXn) type ligands. IV. The preparation and properties of tetraammine(salicylideneaminato)cobalt(III) and diamminebis(salicylideneaminato)cobalt(III) complexes.
- Cobalt(III) complexes with quadridentate ligands. VII. The preparation and properties of the salicylato or dichloro[tris(2-aminoethyl)amine]cobalt(III) complexes and the related complexes.
- Cobalt(III) Complexes with (N6-nXn)-Type Ligands. VII. Preparation and Properties of Isomers of the (Salicylamidato) cobalt(III) Complexes with Tris(2-aminoethyl)amine, Triethylenetetramine, and Ethylenediamine Ligands.
- Synthesis of 2-benzylidene-3(2H)-benzofuran-3-ones (aurones) by oxidation of 2'-hydroxychalcones with mercury (II) acetate.