Tripsin-Catalyzed Peptide Synthesis with Various p-Guanidinophenyl Esters as Acyl Donors
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概要
- 論文の詳細を見る
Trypsin-catalyzed peptide synthesis has been studied by using p-guanidinophenyl esters of N^α-(tert-butyloxycarbonyl)amino acid and peptide as acyl donor components. The reaction conditions were optimized for organic solvents, pH, and concentration of acceptor. The method was especially useful for the preparation of various peptides containing D-amino acids. The enzymatic hydrolysis of the resulting products was negligible.
- 1996-08-15
著者
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Toyota Eiko
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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Sekizaki Haruo
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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Toyota E
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Toyota Eiko
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Itoh Kunihiko
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Sekizaki H
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Sekizaki Haruo
Faculty Of Pharmaceutical Sciences Health Science University Of Hokkaido
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TANIZAWA Kazutaka
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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Tanizawa K
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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Sekizaki Haruo
Faculty of Pharmaceutical Science, Higashi Nippon Gakuen University
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Toyota Eiko
Faculty of Pharmaceutical Science, Higashi Nippon Gakuen University
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