Effect of D-Sorbitol on the Thermal Gelation of Methylcellulose Formulations for Drug Delivery
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概要
- 論文の詳細を見る
The aim of this study was to examine the effect of D-sorbitol on the gelation characteristics of methylcellulose in aqueous solution. The addition of D-sorbitol at concentrations of between 25 and 30% (w/v) to 1.0—2.0% (w/v) methylcellulose solutions reduced the gelation temperature from approximately 53 °C to values between ambient and 37 °C and increased the strength of the gel. The in vitro release of acetaminophen (paracetamol) from 2.0% (w/v) methylcellulose gels containing 20—30% (w/v) D-sorbitol gel was diffusion-controlled.
- 公益社団法人 日本薬学会の論文
著者
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Kimura Tomoki
Faculty Of Pharmaceutical Sciences Setsunan University
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Attwood David
School Of Pharmacy And Pharmaceutical Sciences University Of Manchester
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Itoh Kunihiko
Faculty Of Pharmaceutical Sciences Health Sciences University Of Hokkaido
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MIYAZAKI Shozo
Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido
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Hatakeyama Tomoaki
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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Shimoyama Tetsuya
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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DEmanuele Antony
School of Pharmacy and Pharmaceutical Sciences, University of Central Lancashire
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Kimura Tomoki
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
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