AN INDUCTION EFFECT OF PHENOBARBITAL ON RAT LIVER MICROSOMAL 4-HYDROXYLATION OF ESTRADIOL 17-SULFATE
スポンサーリンク
概要
- 論文の詳細を見る
Induction effect of phenobarbital (80mg/kg, daily for 4d), 3-methylcholanthrene (40mg/kg, daily for 4d), and isosafrole (150mg/kg, daily for 4d), on 2-and 4-hydroxylations of estradiol 17-sulfate by rat liver microsomes with an NADPH-generating system was investigated. On catechol formation from estradiol 17-sulfate, only phenobarbital caused some increase of the 2-hydroxylase activity in both sexes. While 4-hydroxylase activity was caused effectively by phenobarbital and isosafrole in both sexes, especially, the induction by the former in male rats was over six-fold increase to the control.
- 公益社団法人日本薬学会の論文
著者
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WATANABE Kazuhiro
Hokkaido Pharmaceutical University, School of Pharmacy
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YOSHIZAWA Itsuo
Hokkaido College of Pharmacy
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Yoshizawa Itsuo
Hokkaido Institute Of Pharmaceutical Science
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KIMURA REIJI
Hokkaido Institute of Pharmaceutical Sciences
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Kimura Reiji
Hokkaido Institute Of Pharmaceutical Science
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Watanabe Kazuhiro
Hokkaido Institute Of Pharmaceutical Science
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