INDUCTION OF LIVER MICROSOMAL 2-HYDROXYLATION OF ESTRADIOL 17-SULFATE BY PHENOBARBITAL IN MALE RAT
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概要
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Estradiol 17-sulfate 2-hydroxylase activity was measured in liver microsomes of 7-to 8-weeks-old Wistar male rats. Phenobarbital (80 mg/kg, daily for 4 d) injected intraperitoneally caused 30% increase of the enzyme activity and 160% increase of the microsomal cytochrome P-450 content. Treatment of rats with 3-methylcholanthrene (40 mg/kg, daily for 4 d) injected intraperitoneally caused no induction effect on 2-hydroxylase activity, but P-450 content was increased by 113%. Both the P-450 content and the enzyme activity were reduced to about half of the control, when the animals were injected subcutaneously with cobaltous chloride (30 mg/kg, daily for 2 d).
- 公益社団法人日本薬学会の論文
著者
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WATANABE Kazuhiro
Hokkaido Pharmaceutical University, School of Pharmacy
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YOSHIZAWA Itsuo
Hokkaido College of Pharmacy
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Watanabe Kazuhiro
Hokkaido Institute Of Pharmaceutical Science
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