Immunochemical Studies for the Presence of P-450 HFLa, a Form of Cytochrome P-450 in Human Fetal Livers in Human Hepatocellular Carcinoma Cells

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概要

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• Immunohistochemical localization of P-450 HFLa, a form of cytochrome P-450 in human fetal livers was in vestigated in human hepatocellular carcinoma. The cytoplasm of carcinoma cells positively reacted with anti-P-450 HFLa antibodies. It was found that the carcinoma cells showing a pseudo-glandular pattern or poorly differentiated appearance exhibited a weaker reactivity with anti-P-450 HFLa antibodies than did relatively differentiated carcinoma cells. In the case of hepatoblastoma, the polygonal or round-shaped tumor cells which differentiated into epithelial structure exhibited a positive reaction with anti-P-450 HFLa antibodies, whereas the spindle-shaped tumor cells which showed a sarcomatous appearance did not react with the antibodies.

• 公益社団法人日本薬学会の論文

著者

• TAKEUCHI Jun

  Faculty of Pharmaceutical Sciences, Osaka University

• KAMATAKI Tetsuya

  Faculty of Pharmaceutical Sciences, Hokkaido University

• Kamataki T

  Hokkaido Univ. Sapporo Jpn

• Kamataki Tetsuya

  Department Of Pharmacology School Of Medicine Keio University:department Of Analytical Biochemistry

• ITAHASHI Koshiro

  Kawasaki Seitetsu Hospital

• KITADA Mitsukazu

  Faculty of Pharmaceutical Sciences, Hokkaido University

• TSUKIDATE Kazuo

  Faculty of Pharmaceutical Sciences, Hokkaido University

• TANEDA Masaki

  Faculty of Pharmaceutical Sciences, Hokkaido University

• KOMORI Masayuki

  Faculty of Pharmaceutical Sciences, Hokkaido University

• OHI Hiroaki

  Faculty of Pharmaceutical Sciences, Hokkaido University

• ITAHASHI Koshiro

  Faculty of Pharmaceutical Sciences, Hokkaido University

• Kamataki Tetsuya

  Division Of Analytical Biochemistry Faculty Of Pharmaceutical Sciences Hokkaido University

• Kitada Mitsukazu

  Division Of Analytical Biochemistry Faculty Of Pharmaceutical Sciences Hokkaido University

• Kitada Mitsukazu

  Faculty Of Pharmaceutical Sciences Chiba University

• Ohi Hiroaki

  Division Of Analytical Biochemistry Faculty Of Pharmaceutical Sciences Hokkaido University:explorato

• Ohi Hiroaki

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• Taneda Masaki

  Faculty Of Pharmaceutical Sciences Hokkaido University:department Of Laboratory Medicine Nagoya Univ

• Tsukidate Kazuo

  Faculty Of Pharmaceutical Sciences Hokkaido University:department Of Laboratory Medicine Nagoya Univ

• Komori Masayuki

  Division Of Analytical Biochemistry Faculty Of Pharmaceutical Sciences Hokkaido University

• Kamataki Tetsuya

  Lab. Drug Metab. Fac. Pharm. Sci. Hokkaido University

• Takeuchi Jun

  Faculty Of Pharmaceutical Sciences Hokkaido University:department Of Laboratory Medicine Nagoya Univ

• Kamataki Tetsuya

  Faculty Of Pharmaceutical Sciences Hokkaido University

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