Effects of Kampo Extracts on Drug Metabolism in Rat Liver Microsomes: Rhei Rhizoma Extract and Glycyrrhizae Radix Extract Inhibit Drug Oxidation
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概要
- 論文の詳細を見る
In the present study, the effects on drug oxidations in rat liver microsomes in vitro using 126 Kampo extracts were investigated. Although the effects of inhibition on drug oxidations were dependent on the Kampo extracts and probe reactions studied, most of the Kampo extracts showed inhibitory effects on both N-demethylations of aminopyrine and erythromycin in rat liver microsomes. Among the Kampo extracts studied herein, Daio-kanzo-to exhibited the most remarkable inhibitory effect on both reactions. The Rhei Rhizoma extract inhibited not only aminopyrine and erythromycin N-demethylations, but also phenacetin O-deethylation, 7-ethoxycoumarin O-deethylation, ethanol oxidation and tolbutamide 4-hydroxylation in rat liver microsomes. The Glycyrrhizae Radix extract also showed a remarkable inhibitory effect on phenacetin O-deethylation as well as aminopyrine and erythromycin N-demethylations. In contrast, the Glycyrrhizae Radix extract virtually showed no effect on ethanol oxidation.
- 社団法人 日本薬理学会の論文
- 2002-06-01
著者
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OHMORI Shigeru
Department of Pharmacy, Shinshu University Hospital
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Hasegawa A
Department Of Earth And Ocean Sciences National Defense Academy
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NAKASA Hiromitsu
Division of Pharmacy, Chiba University Hospital
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KITADA Mitsukazu
Division of Pharmacy, Chiba University Hospital
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Nakamura Hiroyoshi
Division Of Pharmacy University Hospital Chiba University School Of Medicine
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Nakasa Hiromitsu
Division Of Pharmacy Chiba University Hospital
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Kitada Mitsukazu
Division Of Pharmacy University Hospital Chiba University School Of Medicine
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Kitada Mitsukazu
Division Of Analytical Biochemistry Faculty Of Pharmaceutical Sciences Hokkaido University
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Kawaguchi Yoko
Laboratory Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Of Chiba University
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HASEGAWA Atsushi
Division of Pharmacy, Chiba University Hospital, Faculty of Medicine, Chiba University
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Nakamura Hironori
Division Of Pharmacy University Hospital Chiba University School Of Medicine
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Ishii Itsuko
Graduate School Of Pharmaceutical Sciences Chiba University
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Ohmori S
Division Of Pharmacy Shinshu University Hospital
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Ohmori Shigeru
Department Of Pharmacy Shinshu University Hospital
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ISHII Itsuko
Laboratory of Clinical Pharmacology, Faculty of Pharmaceutical Sciences of Chiba University
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Kimura Maharu
Division Of Pharmacy Chiba University Hospital
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Hasegawa Atsushi
Division Of Pharmacy Chiba University Hospital
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OHMORI Shigeru
Department of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba University
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