Cytochrome P450 3As Gene Expression and Testosterone 6β-Hydroxylase Activity in Human Fetal Membranes and Placenta at Full Term
スポンサーリンク
概要
- 論文の詳細を見る
Expression levels of cytochrome P450 (CYP) 3A4, CYP3A5 and CYP3A7 mRNAs in placentas and fetal membranes, which were split into amnion and chorion leave attached decidua (chorion/decidua), obtained from pregnant women with normal delivery (5 subjects) and Caesarean section (15 subjects) were determined. These CYP3A mRNAs were also expressed in amnion and chorion/decidua together with placenta, although the expression level of these mRNAs was strikingly different between subjects. The expression level of the CYP3A4 mRNA in the placenta was about 2-fold higher than those in amnion and chorion/decidua. On the other hand, the expression levels of CYP3A5 and CYP3A7 mRNAs were highest in chorion/decidua. The immunologically related protein(s) with CYP3A7 was detected in all tissues examined. Testosterone 6β-hydroxylase activity in homogenate of human placenta, amnion and chorion/decidua were 26.6, 3.7 and 4.6 pmol/h/mg protein, respectively. These results suggest that CYP3As in fetal membranes have the metabolic function to protect the fetus from exposure to drugs.
- 公益社団法人 日本薬学会の論文
著者
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MATSUNAGA Tamihide
Department of Pharmacy, Shinshu University Hospital
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OHMORI Shigeru
Department of Pharmacy, Shinshu University Hospital
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Kanai Makoto
Department Of Family And Child Nursing And Midwifery Shinshu University School Of Health Sciences
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Ohmori Shigeru
Department Of Pharmacy Shinshu University Hospital
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OHIRA Satoshi
Department of Obstetrics and Gynecology, Shinshu University School of Medicine
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MAEZAWA Kayoko
Department of Practical Pharmacy, Keio University Faculty of Pharmacy
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Maezawa Kayoko
Department Of Practical Pharmacy Keio University Faculty Of Pharmacy
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Ohira Satoshi
Department Of Family And Child Nursing And Midwifery Shinshu University School Of Health Sciences
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Takezawa Takashi
Department of Pharmacy, Shinshu University Hospital
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Matsunaga Tamihide
Department Of Pharmacy Shinshu University Hospital
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Takezawa Takashi
Department Of Mechanical Engineering Faculty Of Engineering Yokohama National University
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Kanai Makoto
Department of Family and Child Nursing, and Midwifery
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Maezawa Kayoko
Department of Pharmacy, Shinshu University Hospital
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OHMORI Shigeru
Department of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba University
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Matsunaga Tamihide
Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University
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