The Effects of Japanese Herbal Medicines on Drug Oxidations in Rat Liver Microsomes in vitro

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概要

• 論文の詳細を見る

• Some Japanese herbal medicines (Kampo medicines) have been shown to inhibit the activity of aminopyrine N-demethylase in rat liver microsomes. Namely, Sho-seiryu-to and Keishi-kajutubu-to inhibited not only aminopyrine N-demethylation but also erythromycin N-demethylation, 7-ethoxycoumarin 0-deethylation, 4-nitrophenol 7 -hydroxylation, desipramine 2-hydroxylation and coumarin 7-hydroxylation in rat liver microsomes to varying extents. Cinnamon Bark, Schisandra Fruit and Ephedra Herb, which are crude medicine ingredients contained in Sho-seiryu-to, showed a higher potential to inhibit erythromycin N-demethylation than Sho-seiryu-to and other components such as Pinellia Tuber, Glycyrrhiza, Asiasarum Root and Peony Root at the same concentrations. From these results, some Kampo medicines are thought to have an inhibitory effect on cytochrome P450 in rat liver microsomes, and that the inhibitory effect of Sho-seiryu-to on erythromycin N-demethylation may be, at least in part, associated with the ingredient(s) of Cinnamon Bark, Schisandra Fruit and/or Ephedra Herb.

• 日本医療薬学会の論文
• 2002-08-10

著者

• OHMORI Shigeru

  Department of Pharmacy, Shinshu University Hospital

• Hasegawa A

  Department Of Earth And Ocean Sciences National Defense Academy

• KITADA Mitsukazu

  Division of Pharmacy, Chiba University Hospital

• Nakamura Hiroyoshi

  Division Of Pharmacy University Hospital Chiba University School Of Medicine

• Kitada Mitsukazu

  Division Of Pharmacy University Hospital Chiba University School Of Medicine

• Kitada Mitsukazu

  Division Of Analytical Biochemistry Faculty Of Pharmaceutical Sciences Hokkaido University

• HASEGAWA Atsushi

  Division of Pharmacy, Chiba University Hospital, Faculty of Medicine, Chiba University

• ISHII Itsuko

  Faculty of Pharmaceutical Sciences, Chiba University

• Nakamura Hironori

  Division Of Pharmacy University Hospital Chiba University School Of Medicine

• Ishii Itsuko

  Graduate School Of Pharmaceutical Sciences Chiba University

• Ohmori S

  Division Of Pharmacy Shinshu University Hospital

• Ohmori Shigeru

  Department Of Pharmacy Shinshu University Hospital

• KIMURA Maharu

  Division of Pharmacy, University Hospital, Chiba University School of Medicine

• Kimura Maharu

  Division Of Pharmacy Chiba University Hospital

• Hasegawa Atsushi

  Division Of Pharmacy Chiba University Hospital

• OHMORI Shigeru

  Department of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba University

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