Pharmaceutical Properties of Nifedipine from a Ground Mixture with Nifedipine, Casein, Magnesium Silicate and Cellulose Acetate Phthalate
スポンサーリンク
概要
- 論文の詳細を見る
The dissolution step of practically insoluble drugs plays an important role in drug absorption. In this paper, the pharmaceutical properties of a ground mixture of nifedipine are de-scribed. A ground mixture of nifedipine was prepared by grinding with casein, magnesium silicate, and cellulose acetate phthalate in a vibrational ball mill. The X-ray powder diffraction patterns and differential scanning calorimetry data thereafter suggested that nifedipine was present in its amorphous form in the ground mixture. The wettability of the ground mixture was better than that of the physical mixture. The solubility of amorphous nifedipine in water was also better than that in crystalline. Both the dissolution rate and the bioavailability of amorphous nifedipine in the ground mixture were significantly greater than those of the physical mixture. The above results thus suggest that a mixture grinding method not only improves the solubility of nifedipine and the dissolution profile of its preparation but also enhances its bioavailability after oral administration.
- 日本医療薬学会の論文
- 1997-04-10
著者
-
TAKAHASHI NOBUHIKO
Department of General Medicine, Asahikawa Medical College
-
MIZUGAKI Michinao
Department of Clinical Pharmaceutics, Tohoku Pharmaceutical University
-
NAKAMURA Hironori
Department of Applied Physics, University of Fukui
-
Kudo Yoshiki
Department Of Pharmaceutical Sciences Tohoku University Hospital And Division Of Clinical Pharmacy G
-
Kudo Yoshiki
Department Of Obstetrics & Gynecology Hiroshima University
-
Kudo Yoshiki
Department Of Pharmaceutical Sciences Tohoku University Hospital
-
SATO HIDEAKI
Department of Pharmaceutical Sciences, Tohoku University Hospital
-
OHYAMA MIWAKO
Department of Pharmaceutical Sciences, Tohoku University Hospital
-
DOI KENGO
Department of Pharmaceutical Formulation Research and Development, Takata Seiyaku Co., Ltd
-
Nakamura Hiroyoshi
Division Of Pharmacy University Hospital Chiba University School Of Medicine
-
Mizugaki Michinao
Department Of Clinical Pharmaceutics Tohoku Pharmaceutical University
-
Nakamura Hironori
Department Of Applied Physics University Of Fukui
-
Takahashi Nobuhiko
Department Of General Medicine Asahikawa Medical College
-
Takahashi Nobuhiko
Department Of Pharmaceutical Formulation Research And Development Takata Seiyaku Co. Ltd
-
Nakamura Hironori
Division Of Pharmacy University Hospital Chiba University School Of Medicine
-
Doi Kengo
Department Of Pharmaceutical Formulation Research And Development Takata Seiyaku Co. Ltd
-
Ohyama Miwako
Department Of Pharmaceutical Sciences Tohoku University Hospital
-
Sato Hideaki
Department Of Pediatric Surgery St. Marianna University Hospital:children's Research Centre Our
-
Sato Hideaki
Department Of Applied Physics Faculty Of Engineering Osaka University
-
Kudo Yoshiki
Department Of Neuropsychiatry Graduate School Of Medicine University Of Tokyo
関連論文
- Reconstitution of the Immune System after Murine Allogeneic Umbilical Cord Blood Transplantation
- Lipopolysaccharide induces adipose differentiation-related protein expression and lipid accumulation in the liver through inhibition of fatty acid oxidation in mice
- 日本人におけるHNF4αの遺伝子多型の同定及びハプロタイプ構造の解析
- Genotyping of Single Nucleotide Polymorphisms (SNPs) Influencing Drug Response by Competitive Allele-specific Short Oligonucleotide Hybridization (CASSOH) with Immunochromatographic Strip
- NMR Study of the Successive Phase Transitions in CuB_2O_4(Spin, Orbital, Charge and Lattice Coupled Systems, Field-Induced Phase Transitions and Dynamics in Quantum Spin Systems)
- Left Ventricular Regional Variations in Myosin Isoform Shift in Dahl Salt-Sensitive Hypertensive Rats
- Dietary Salt Loading Increases Nitric Oxide Synthesis in Transgenic Mice Overexpressing Sodium-Proton Exchanger
- P438 EXPERIMENTAL PRODUCTION OF MITRAL ANNULAR CALCIFICATION IN MITRAL COMPLEX LESIONS INDUCED BY VAGUS STIMULATION IN RABBITS
- 1077 EFFECTS OF OUABAIN AND DIETARY SALT ON CONTRACTION AND RELAXATION OF ARTERIAL SMOOTH MUSCLE OF Na^+ /H^+ EXCHANGER OVEREXPRESSED TRANSGENIC MICE
- -0156- NOREPINEPHRINE-INDUCED CONTRACTION AND EFFECTS OF VERAPAMIL AND RYANODINE IN ISOLATED AORTIC RINGS FROM TRANSGENIC MICE OVEREXPRESSING Na^+/H^+ EXCHANGER(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- Design, Production, and Characterization of Recombinant Neocarzinostatin Apoprotein in Escherichia coli
- Phenobarbital Molecularly Imprinted Polymer Selectively Binds Phenobarbital
- PHARMACOKINETICS AND CLINICAL EFFECTS OF CEFOZOPRAN IN PEDIATRIC PATIENTS
- Pharmaceutical Properties of Nifedipine from a Ground Mixture with Nifedipine, Casein, Magnesium Silicate and Cellulose Acetate Phthalate
- Blue rubber bleb nevus syndrome : Report of a patient with hemangiomas of the vaginal portion of the cervix appearing during pregnancy
- P57kip2 immunohistochemical expression and ultrastructural findings of gestational trophoblastic disease and related disorders
- Determination of urinary 12(S)-hydroxyeicosatetraenoic acid by liquid chromatography-tandem mass spectrometry with column-switching technique : sex difference in healthy volunteers and patients with diabetes mellitus
- Preparation of Neocarzinostatin Apoprotein Mutants and the Randomized Library on the Chromophore-Binding Cavity(Miscellaneous)
- 4 Pro-R Hydrogen of NADPH was Abstracted for Enzymatic Hydride Transfer by N-Ethylmaleimide Reductase of Yarrowia lipolytica
- IS P-2 Sonic Hedgehog Gene Expression in Nitrofen Induced Hypoplastic Lungs in Mice(International Poster 1,Science and Art for Sick Children)
- 気管支喘息児における血清ビタミンA濃度の検討
- 日本人における Denaturing HPLC を用いたCYP2S1遺伝子の新規SNPスクリーニング
- Oral branched-chain amino acid supplementation improves the oxidized/reduced albumin ratio in patients with liver cirrhosis
- Genotyping of the N-acetyltransferase2 Polymorphism in the Prediction of Adverse Drug Reactions to Isoniazid in Japanese Patients
- High Throughput Detection of Drug-Metabolizing Enzyme Polymorphisms by Allele-Specific Fluorogenic 5' Nuclease Chain Reaction Assay
- Detection Assay of Rare Variants of the Thiopurine Methyltransferase Gene by PCR-RFLP Using a Mismatch Primer in a Japanese Population
- Identification of Inhibitory Component in Cinnamon : O-Methoxycinnamaldehyde Inhibits CYP1A2 and CYP2E1
- Estimation of Chemical Structure of Notopterol Metabolites
- Determination of Serum Concentrations of Glycyrrhizin in Humans by Semi-micro High-Performance Liquid Chromatography after Administration of a Therapeutic Dose
- Intra- and Inter-Day Variation of LTE4 Levels in Healthy Human Urine Using the Liquid Chromatography/Tandem Mass Spectrometric Method (質量分析総合討論会特集号)
- Determination of leukotriene E_4 in human urine using liquid chromatography-tandem mass spectrometry
- Preparation of a Monoclonal Antibody Specific for 5-Methyl-2'-deoxycytidine and Its Application for the Detection of DNA Methylation Levels in Human Peripheral Blood Cells
- A Sandwich Enzyme-linked Immunosorbent Assay for Δ^3, Δ^2-Enoyl-CoA Isomerase in Rat-Tissue Homogenates
- Comparison of Serum and Urinary Levels of Modified Nucleoside, 1-Methyladenosine, in Cancer Patients Using a Monoclonal Antibody-Based Inhibition ELISA
- Fas-Mediated Apoptosis is Enhanced by Glycyrrhizin without Alteration of Caspase-3-Like Activity
- Creatinine at the Evaluation of Urinary 1-Methyladenosine and Pseudouridine Excretion
- A 63 kDa Tumor Necrosis Factor Inhibitor Released from a Human Monocytic Leukemia Cell Line, THP-1
- MOLECULAR CLONING OF THE nemA GENE ENCODING N-ETHYLMALEIMIDE REDUCTASE FROM Escherichia coli
- Subcellular Distribution of Rat Liver NADPH-2,4-Dienoyl-CoA Reductase
- Expression of DNA Methyltransferase (Dnmt1) in Testicular Germ Cells during Development of Mouse Embryo
- Increased Expression of Queuosine Synthesizing Enzyme, tRNA-Guanine Transglycosylase, and Queuosine Levels in tRNA of Leukemic Cells
- Satratoxin H Generates Reactive Oxygen Species and Lipid Peroxides in PC12 Cells(Pharmacology)
- Troglitazone Induces G1 Arrest by p27^ Induction That Is Mediated by Inhibition of Proteasome in Human Gastric Cancer Cells
- Report on the preparation of deuterium-labelled aconitine and mesaconitine and their application to the analysis of these alkaloids from body fluids as internal standard
- Activation of Fronto-Limbic System in the Human Brain by Cigarette Smoking : Evaluated by a CBF Measurement
- Three Novel Single Nucleotide Polymorphisms (SNPs) of the CYP2B6 Gene in Japanese Individuals
- Human CYP4B1 Gene in the Japanese Population Analyzed by Denaturing HPLC
- Gene expression profiling of advanced-stage serous ovarian cancers distinguishes novel subclasses and implicates ZEB2 in tumor progression and prognosis
- Effects of Continuous Ingestion of Green Tea or Grape Seed Extracts on the Pharmacokinetics of Midazolam
- The Effects of Japanese Herbal Medicines on Drug Oxidations in Rat Liver Microsomes in vitro
- Effects of Kampo Extracts on Drug Metabolism in Rat Liver Microsomes: Rhei Rhizoma Extract and Glycyrrhizae Radix Extract Inhibit Drug Oxidation
- Molecular Cloning of Monkey CYP2C43 cDNA and Expression in Yeast
- Effect of Grapefruit Juice on the Urinary 6β-hydroxycortisol/cortisol Ratio
- Inhibition of cell invasion and morphological change by troglitazone in human pancreatic cancer cells
- Forensic Assessment of 16 Single Nucleotide Polymorphisms Analyzed by Hybridization Probe Assay
- PPARγ ligand-induced apoptosis through a p53-dependent mechanism in human gastric cancer cells
- Intracisternal Injection of Basic Fibroblast Growth Factor Reduces the Severity of Gastric Mucosal Lesions Evoked by Ethanol in Rats
- Brain and Heart Specific Alteration of Methamphetamine (MAP) Distribution in MAP-Sensitized Rat
- Cross-Flow Filtration of Machining Fluids by Microfiltration Membranes : Influence of Chip Size on Permeation Flux
- A Longitudinal Study on the Nutritional State of Elderly Women at a Nursing Home in Japan
- Spectroscopy of Laser Scattered Light by Eye Lens
- Isolation of Bovine Serum Albumin Fragment P-9 and P-9-Mediated Fusion of Small Unilamellar Vesicles
- A 1024-Channel Digital Apparatus for Measurements of the Time Interval Distribution
- Construction of a System that Simultaneously Evaluates CYP1A1 and CYP1A2 Induction in a Stable Human-derived Cell Line using a Dual Reporter Plasmid
- Study of Liquid Crystal Alignment Formed Using Slit Coater
- Case of IgG4-related retroperitoneal fibrosis with concomitant rheumatoid arthritis
- Preparation of a Monoclonal Antibody Specific to Chum Salmon Growth Hormone
- Altered renin-angiotensin system gene expression causes renal hypoplasia in the rats with nitrofen-induced diaphragmatic hernia
- Visualizing expression patterns of Shh and Foxf1 genes in the foregut and lung buds by optical projection tomography
- Impaired alveolar epithelial cell differentiation in the hypoplastic lung in nitrofen-induced congenital diaphragmatic hernia
- The effect of surface roughness on the Weibull distribution of porcelain strength
- Effects of thermal cycling and surface roughness on the Weibull distribution of porcelain strength
- A Population-based Study of Arterial Stiffness Index in Relation to Cardiovascular Risk Factors
- A Digital Full-Autocorrelator for Photoelectric Pulses
- An Experimental Study on Allograft of Cryopreserved Articular Cartilage
- Acupuncture modulates mechanical responses of smooth muscle produced by transmural nerve stimulation in gastric antrum of genetically hyperglycemic rats
- Sonic hedgehog gene expression in nitrofen induced hypoplastic lungs in mice
- An association analysis of Per2 with panic disorder in the Japanese population
- ISP4-01 Laparoscopic Excision of Urachal Remnants in children : What's indication for it?
- Method for individualized evaluation of antiemetic effect induced by 5-HT3 receptor antagonist
- Effects of Spiradoline Mesylate, a Selective .KAPPA.-Opioid-Receptor Agonist, on the Central Dopamine System with Relation to Mouse Locomotor Activity and Analgesia.