Excellent Chiral Introduction by Diene Iron-Tricarbonyl Moiety. III : Asymmetric Synthesis of Hydroxyethylidene Dipeptide Isostere Using a Diastereoselective 1,2-Nucleophilic Addition of Organocerium Reagents into a 1-Azatriene Fe(CO)_3 Complex

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概要

• 論文の詳細を見る

• A 1-iminobutadiene-iron tricarbonyl [Fe(CO)_3] complex (1) reacts with various organometallic nucleophiles in a stereoselective manner, and especially, by use of organocerium reagents, only single secondary amine complexes (2) were obtained in good yields. Application of this methodology was demonstrated in the asymmetric synthesis of hydroxyethylidene dipeptide isostere from the chiral starting material N-{(2R)-(2E)-tricarbonyl[2-5-η-2,4-pentadienylidene]iron} benzylamine (1b).

• 社団法人日本薬学会の論文
• 1996-05-15

著者

• 竹本 佳司

  Faculty Of Pharmaceutical Sciences Osaka University

• 岩田 宙造

  阪大院薬

• Takemoto Yoshiji

  Faculty Of Pharmaceutical Sciences Osaka University

• Takemoto Y

  Graduate School Of Pharmaceutical Sciences Kyoto University

• TAKEUCHI Jun

  Faculty of Pharmaceutical Sciences, Osaka University

• IWATA Chuzo

  Faculty of Pharmaceutical Sciences, Osaka University

• MATSUI Eiki

  Faculty of Pharmaceutical Sciences, Osaka University

• Iwata Chuzo

  Faculty Of Pharmaceutical Sciences Osaka University

• Matsui Eiki

  Faculty Of Pharmaceutical Sciences Osaka University

• Takeuchi J

  Department Of Materials Science Shimane University

• Takeuchi J

  Department Of Physics Faculty Of Science Shimane University

• Takeuchi J

  Faculty Of Pharmaceutical Sciences Osaka University

• Takeuchi Jun

  Faculty Of Pharmaceutical Sciences Hokkaido University:department Of Laboratory Medicine Nagoya Univ

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